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Turning basic science discoveries into successful commercial opportunities

Van Rooij, Eva (Oxford University Press, 2019-10-01)
Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Dutta, Devanjali; Heo, Inha; O'Connor, Roberta (MYJoVE Corporation, 2019-09-14)

Cryptosporidium parvum is one of the major causes of human diarrheal disease. To understand the pathology of the parasite and develop efficient drugs, an in vitro culture system that recapitulates the conditions in the ...
The Prevalence of Intradialytic Hypotension in Patients on Conventional Hemodialysis: A Systematic Review with Meta-Analysis

Kuipers, Johanna; Verboom, Loes M.; Ipema, Karin J.R.; Paans, Wolter; Krijnen, Wim P.; Gaillard, Carlo A.J.M.; Westerhuis, Ralf; Franssen, Casper F.M. (S. Karger AG, 2019-06-01)

Background: Intradialytic hypotension (IDH) is considered to be a frequent complication of hemodialysis (HD) and is associated with symptom burden, increased incidence of access failure, cardiovascular events, and higher ...
Renal concentrating ability and glomerular filtration rate in lithium-treated patients

Doornebal, J.; Diepenbroek, A.; van de Luijtgaarden, M. W.M.; Hartong, E. G.T.M.; Grootens, K. P.; Kupka, R. W.; Klumpers, U. M.H.; Deen, P. M.T.; Gaillard, C. A.; Wetzels, J. F.M. (Van Zuiden Communications BV, 2019-05-01)

BACKGROUND: Lithium is the most effective drug for mood stabilization in bipolar disorder. However, lithium exposure has been associated with an impaired renal concentrating ability (RCA) and glomerular filtration rate ...
Movement Behavior Patterns in People With First-Ever Stroke

Wondergem, Roderick; Veenhof, Cindy; Wouters, Eveline M.J.; de Bie, Rob A.; Visser-Meily, Johanna M.A.; Pisters, Martijn F. (Lippincott Williams & Wilkins, 2019-12-01)

Background and Purpose- Movement behaviors, that is, both physical activity and sedentary behavior, are independently associated with health risks. Although both behaviors have been investigated separately in people after ...
Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

Lehle, Anna S.; Farin, Henner F.; Marquardt, Benjamin; Michels, Birgitta E.; Magg, Thomas; Li, Yue; Liu, Yanshan; Ghalandary, Maryam; Lammens, Katja; Hollizeck, Sebastian; Rohlfs, Meino; Hauck, Fabian; Conca, Raffaele; Walz, Christoph; Weiss, Batia; Lev, Atar; Simon, Amos J.; Groß, Olaf; Gaidt, Moritz M.; Hornung, Veit; Clevers, Hans; Yazbeck, Nadine; Hanna-Wakim, Rima; Shouval, Dror S.; Warner, Neil; Somech, Raz; Muise, Aleixo M.; Snapper, Scott B.; Bufler, Philip; Koletzko, Sibylle; Klein, Christoph; Kotlarz, Daniel (W.B. Saunders, 2019-01-01)
Disease severity in respiratory syncytial virus infection: Role of host genetic variation

Tahamtan, Alireza; Askari, Fatemeh Sana; Bont, Louis; Salimi, Vahid (John Wiley & Sons Inc., 2019-03-01)

Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs ...
Fail-fast in respiratory syncytial virus vaccine development

Besteman, Sjanna B.; Bont, Louis J. (American Thoracic Society, 2019-08-15)
Update of a clinical prediction model for serious bacterial infections in preschool children by adding a host-protein-based assay: A diagnostic study

Van Houten, Chantal; Van De Maat, Josephine Sophia; Naaktgeboren, Christiana; Bont, Louis; Oostenbrink, R. (BMJ Publishing Group, 2019-09-01)

Objective To determine whether updating a diagnostic prediction model by adding a combination assay (tumour necrosis factor-related apoptosis-inducing ligand, interferon γinduced protein-10 and C reactive protein (CRP)) ...
Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP

ADNP Consortium (Elsevier, 2019-02-15)

Background: In genome-wide screening studies for de novo mutations underlying autism and intellectual disability, mutations in the ADNP gene are consistently reported among the most frequent. ADNP mutations have been ...
Anakinra in children and adults with Still's disease

Vastert, Sebastiaan J.; Jamilloux, Yvan; Quartier, Pierre; Ohlman, Sven; Osterling Koskinen, Lisa; Kullenberg, Torbjörn; Franck-Larsson, Karin; Fautrel, Bruno; De Benedetti, Fabrizio (Oxford University Press, 2019-11-01)

Systemic juvenile idiopathic arthritis and adult-onset Still's disease are rare autoinflammatory disorders with common features, supporting the recognition of these being one disease-Still's disease-with different ages of ...
Curriculum for endoscopic submucosal dissection training in Europe: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

Pimentel-Nunes, Pedro; Pioche, Mathieu; Albéniz, Eduardo; Berr, Frieder; Deprez, Pierre; Ebigbo, A.; Dewint, Pieter; Haji, Amyn; Panarese, Alba; Weusten, Bas L.A.M.; Dekker, Evelien; East, James E.; Sanders, David S.; Johnson, Gavin; Arvanitakis, Marianna; Ponchon, Thierry; Dinis-Ribeiro, Mário; Bisschops, Raf (Georg Thieme Verlag, 2019-08-30)

Main Recommendation There is a need for well-organized comprehensive strategies to achieve good training in ESD. In this context, the European Society of Gastrointestinal Endoscopy (ESGE) have developed a European core ...
Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

Eating Disorders Working Group of the Psychiatric Genomics Consortium (Elsevier, 2019-10-15)

Background: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic ...
Polygenic burden in focal and generalized epilepsies

Epi25 Consortium (Oxford University Press, 2019-11-01)

Rare genetic variants can cause epilepsy, and genetic testing has been widely adopted for severe, paediatric-onset epilepsies. The phenotypic consequences of common genetic risk burden for epilepsies and their potential ...
Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes

Samson, Leonard Daniël; Boots, A Mieke H; Verschuren, W M Monique; Picavet, H Susan J; Engelfriet, Peter; Buisman, Anne-Marie (Elsevier, 2019-10-01)

BACKGROUND: With aging, the human immune system undergoes several changes. The clinical relevance of these changes, however, is relatively unknown. We investigated immunological aspects of human aging in relation to frailty ...
Inflammatory and Fibrotic Mediators in Renal Diseases

Rayego-Mateos, Sandra; Goldschmeding, Roel; Ruiz-Ortega, Marta (John Wiley & Sons Inc., 2019-01-01)
The genomic landscape of CAKUT; you gain some, you lose some

Knoers, Nine V.A.M.; Renkema, Kirsten Y. (Elsevier, 2019-08-01)
Radioembolization with Y-90 Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy

Braat, A J A T; Ahmadzadehfar, H; Kappadath, S C; Stothers, C L; Frilling, A; Deroose, C M; Flamen, P; Brown, D B; Sze, D Y; Mahvash, A; Lam, M G E H (Springer-Verlag, 2020-02-01)

PURPOSE: Peptide receptor radionuclide therapy (PRRT) and radioembolization are increasingly used in neuroendocrine neoplasms patients. However, concerns have been raised on cumulative hepatotoxicity. The aim of this ...
Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Lambrichts, Daniël P.V.; Vennix, Sandra; Musters, Gijsbert D.; Mulder, Irene M.; Swank, Hilko A.; Hoofwijk, Anton G.M.; Belgers, Eric H.J.; Stockmann, Hein B.A.C.; Eijsbouts, Quirijn A.J.; Gerhards, Michael F.; van Wagensveld, Bart A.; van Geloven, Anna A.W.; Crolla, Rogier M.P.H.; Nienhuijs, Simon W.; Govaert, Marc J.P.M.; di Saverio, Salomone; D'Hoore, André J.L.; Consten, Esther C.J.; van Grevenstein, Wilhelmina M.U.; Pierik, Robert E.G.J.M.; Kruyt, Philip M.; van der Hoeven, Joost A.B.; Steup, Willem H.; Catena, Fausto; Konsten, Joop L.M.; Vermeulen, Jefrey; van Dieren, S.; Bemelman, Willem A.; Lange, Johan F.; Hop, W. C.; Opmeer, B. C.; Reitsma, J. B.; Meijer, D. W.; Matthijsen, R.; Blom, R.; Wijsman, J. H.; de Maat, M. F.G.; Boom, M. J.; de Vries, M.; Stam, M. A.W.; Verweij, M. S.; Steller, E. P.; de Graaf, E. J.R.; Vermaas, M.; Wiezer, M. J.; Smits, A. B.; Hendriks, E. R.; Borel Rinkes, I. H.M.; Molenaar, I. Q.; Nijs, S. (Elsevier Limited, 2019-08-01)

Background: Previous studies have suggested that sigmoidectomy with primary anastomosis is superior to Hartmann's procedure. The likelihood of stoma reversal after primary anastomosis has been reported to be higher and ...
Appropriate shocks and mortality in patients with versus without diabetes with prophylactic implantable cardioverter defibrillators

Juhani Junttila, M.; Pelli, Ari; Kenttä, Tuomas V.; Friede, Tim; Willems, Rik; Bergau, Leonard; Malik, Marek; Vandenberk, Bert; Vos, Marc A.; Schmidt, Georg; Merkely, Bela; Lubinski, Andrzej; Svetlosak, Martin; Braunschweig, Frieder; Harden, Markus; Zabel, Markus; Huikuri, Heikki V.; Sticherling, Christian; for the EU-CERT-ICD Investigators (American Diabetes Association Inc., 2020-01-01)

OBJECTIVE: Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to sudden death in diabetes are not well known. We compared the incidence of appropriate shocks and ...

Now showing items 21961-21980 of 40729