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UMC Repository: Recent submissions

  • Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion 
    Guglielmi, Valeria; LeCouffe, Natalie E.; Zinkstok, Sanne M.; Compagne, Kars C.J.; Eker, Reyhan; Treurniet, Kilian M.; Tolhuisen, Manon L.; van der Worp, H. Bart; Jansen, Ivo G.H.; van Oostenbrugge, Robert J.; Marquering, Henk A.; Dippel, Diederik W.J.; Emmer, Bart J.; Majoie, Charles B.L.M.; Roos, Yvo B.W.E.M.; Coutinho, Jonathan M.; MR CLEAN Registry Investigators (Lippincott Williams & Wilkins, 2019-12-01)
    Background and Purpose- Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a ...
  • Activation of a bovine mammary epithelial cell line by ruminant-associated staphylococcus aureus is lineage dependent 
    Hoekstra, Jurriaan; Rutten, Victor P.M.G.; Lam, Theo J.G.M.; Van Kessel, Kok P.M.; Spaninks, Mirlin P.; Stegeman, J. Arjan; Benedictus, Lindert; Koop, Gerrit (MDPI AG, 2019-12-01)
    Bovine mastitis is a costly disease to the dairy industry and intramammary infections (IMI) with Staphylococcus aureus are a major cause of mastitis. Staphylococcus aureus strains responsible for mastitis in cattle ...
  • Up to 12 years clinical evaluation of 197 partial indirect restorations with deep margin elevation in the posterior region 
    Bresser, R. A.; Gerdolle, D.; van den Heijkant, I. A.; Sluiter-Pouwels, L. M.A.; Cune, M. S.; Gresnigt, M. M.M. (Elsevier, 2019-12-01)
    Objectives: Deep margin elevation (DME) relocates the cervical outline of large-sized cavity dimensions in the posterior area supragingivally, using a resin composite in a direct technique. The aim of this study is to ...
  • Mortality risk in atrial fibrillation: the role of aspirin, vitamin K and non-vitamin K antagonists 
    Gieling, Emilie; de Vries, Frank; Williams, Rachael; van Onzenoort, Hein A.W.; de Boer, Anthonius; ten Cate, Vincent; Kramers, Cornelis; Burden, Andrea (Springer Netherlands, 2019-12-01)
    Background As an alternative to vitamin K antagonist and low-dose aspirin (< 325 mg), non-vitamin K oral anticoagulants are available for the prevention of stroke in patients with atrial fibrillation. However, the mortality ...
  • Responder Threshold for Patient-Oriented Eczema Measure (POEM) and Children’s Dermatology Life Quality Index (CDLQI) in Adolescents with Atopic Dermatitis 
    Simpson, Eric L.; de Bruin-Weller, Marjolein; Eckert, Laurent; Whalley, Diane; Guillemin, Isabelle; Reaney, Matthew; Chen, Zhen; Nelson, Lauren; Qin, Shanshan; Bansal, Ashish; Gadkari, Abhijit (Springer-Verlag, 2019-12-01)
    Introduction: The Patient-Oriented Eczema Measure (POEM) assesses patient-reported frequency of atopic dermatitis (AD) symptoms, while the Children’s Dermatology Life Quality Index (CDLQI) measures the impact of skin disease ...
  • Sequence variants with large effects on cardiac electrophysiology and disease 
    Norland, Kristjan; Sveinbjornsson, Gardar; Thorolfsdottir, Rosa B.; Davidsson, Olafur B.; Tragante, Vinicius; Rajamani, Sridharan; Helgadottir, Anna; Gretarsdottir, Solveig; van Setten, Jessica; Asselbergs, Folkert W.; Sverrisson, Jon Th; Stephensen, Sigurdur S.; Oskarsson, Gylfi; Sigurdsson, Emil L.; Andersen, Karl; Danielsen, Ragnar; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Arnar, David O.; Sulem, Patrick; Holm, Hilma; Gudbjartsson, Daniel F.; Stefansson, Kari (Nature Publishing Group, 2019-12-01)
    Features of the QRS complex of the electrocardiogram, reflecting ventricular depolarisation, associate with various physiologic functions and several pathologic conditions. We test 32.5 million variants for association ...
  • Publisher Correction: Sarcoidosis (Nature Reviews Disease Primers, (2019), 5, 1, (45), 10.1038/s41572-019-0096-x) 
    Grunewald, Johan; Grutters, Jan C.; Arkema, Elizabeth V.; Saketkoo, Lesley Ann; Moller, David R.; Müller-Quernheim, Joachim (Nature Publishing Group, 2019-12-01)
    In the originally published version of Figure 2, a figure permissions line was omitted in error. The correct figure permission line has now been added to the HTML and PDF versions of the article, stating “Adapted from ...
  • Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications 
    Dal Canto, Elisa; Ceriello, Antonio; Rydén, Lars; Ferrini, Marc; Hansen, Tina B.; Schnell, Oliver; Standl, Eberhard; Beulens, Joline W.J. (Oxford University Press, 2019-12-01)
    The global prevalence of diabetes is predicted to increase dramatically in the coming decades as the population grows and ages, in parallel with the rising burden of overweight and obesity, in both developed and developing ...
  • Switching to Degludec From Other Basal Insulins Is Associated With Reduced Hypoglycemia Rates: A Prospective Study 
    Fadini, Gian Paolo; Feher, Michael; Hansen, Troels Krarup; de Valk, Harold W.; Koefoed, Mette Marie; Wolden, Michael; Zimmermann, Esther; Jendle, Johan (Endocrine Society, 2019-12-01)
    CONTEXT: Observational studies of insulin degludec (degludec) with hypoglycemia events prospectively recorded are lacking. OBJECTIVE: To evaluate the safety and effectiveness of degludec in patients with type 1 diabetes ...
  • Reflections From the Rearview Mirror: Internal Medicine Physicians' Reactions to Clinical Feedback After Transitions of Responsibility 
    Bowen, Judith L.; Ilgen, Jonathan S.; Regehr, Glenn; Cate, Olle Ten; Irby, David M.; O'Brien, Bridget C. (Wolters Kluwer, 2019-12-01)
    PURPOSE: Learning from practice is important for continuous improvement of practice. Yet little is known about how physicians assimilate clinical feedback and use it to refine their diagnostic approaches. This study described ...
  • Do functional changes occur in the bladder due to bladder outlet obstruction? - ICI-RS 2018 
    Bosch, Ruud; Abrams, Paul; Averbeck, Marcio Augusto; Finazzi Agró, Enrico; Gammie, Andrew; Marcelissen, Tom; Solomon, Eskinder (John Wiley & Sons Inc., 2019-12-01)
    Studies on bladder dysfunction (BD), more specifically functional-urodynamic changes in the bladder as a result of bladder outlet obstruction (BOO) have been summarized for this TT. Based on available, but limited evidence ...
  • Long-Term Durability of Open Surgical versus Endovascular Repair of Intracranial Aneurysms: A Systematic Review and Meta-Analysis 
    Hulsbergen, Alexander F.C.; Mirzaei, Lida; van der Boog, Arthur T.J.; Smith, Timothy R.; Muskens, Ivo S.; Broekman, Marike L.D.; Mekary, Rania A.; Moojen, Wouter A. (Elsevier, 2019-12-01)
    Objective: The long-term durability of different modalities of intracranial aneurysm repair remains unclear. The aim of this study was to conduct a meta-analysis comparing long-term rates of intracranial aneurysm recurrence, ...
  • Reproducibility via coordinated standardization: a multi-center study in a S hank2 genetic rat model for Autism Spectrum Disorders 
    Arroyo-Araujo, María; Graf, Radka; Maco, Martine; van Dam, Elsbeth; Schenker, Esther; Drinkenburg, Wilhelmus; Koopmans, Bastijn; de Boer, Sietse F.; Cullum-Doyle, Michaela; Noldus, Lucas P.J.J.; Loos, Maarten; van Dommelen, Wil; Spooren, Will; Biemans, Barbara; Buhl, Derek L.; Kas, Martien J. (Nature Publishing Group, 2019-08-12)
    Inconsistent findings between laboratories are hampering scientific progress and are of increasing public concern. Differences in laboratory environment is a known factor contributing to poor reproducibility of findings ...
  • Rewiring E2 enzymes 
    Sato, Koichi; Knipscheer, Puck (Nature Research, 2020-01-01)
  • IFN-γ: The T cell's license to kill stem cells in the inflamed intestine 
    Kretzschmar, Kai; Clevers, Hans (American Association for the Advancement of Science, 2019-12-06)
    IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article by Takashima et al.).
  • Genome-wide association study on the early-phase insulin response to a liquid mixed meal: Results from the NEO study 
    Li-Gao, Ruifang; Carlotti, Françoise; De Mutsert, Renée; Van Hylckama Vlieg, Astrid; De Koning, Eelco J.P.; Jukema, J. Wouter; Rosendaal, Frits R.; Van Dijk, Ko Willems; Mook-Kanamori, Dennis O. (American Diabetes Association Inc., 2019-12-01)
    Early-phase insulin secretion is a determinant of postprandial glucose homeostasis. In this study, we aimed to identify novel genetic variants associated with the early-phase insulin response to a liquid mixed meal by a ...
  • Unravelling cellular relationships during development and regeneration using genetic lineage tracing 
    Baron, Chloé S.; van Oudenaarden, Alexander (Nature Research, 2019-12-01)
    Tracking the progeny of single cells is necessary for building lineage trees that recapitulate processes such as embryonic development and stem cell differentiation. In classical lineage tracing experiments, cells are ...
  • Stem cell reprogramming: blood, neurons, and beyond 
    Robin, Catherine; Jaffredo, Thierry; Zaehres, Holm (Elsevier, 2019-12-01)
  • Intronic SMCHD1 variants in FSHD: Testing the potential for CRISPR-Cas9 genome editing 
    Goossens, Remko; Van Den Boogaard, Marlinde L.; Lemmers, Richard J.L.F.; Balog, Judit; Van Der Vliet, Patrick J.; Willemsen, Iris M.; Schouten, Julie; Maggio, Ignazio; Van Der Stoep, Nienke; Hoeben, Rob C.; Tapscott, Stephen J.; Geijsen, Niels; Gonçalves, Manuel A.F.V.; Sacconi, Sabrina; Tawil, Rabi; Van Der Maarel, Silvère M. (BMJ Publishing Group, 2019-12-01)
    Background Facioscapulohumeral dystrophy (FSHD) is associated with partial chromatin relaxation of the DUX4 retrogene containing D4Z4 macrosatellite repeats on chromosome 4, and transcriptional de-repression of DUX4 in ...
  • Advances in β-cell replacement therapy for the treatment of type 1 diabetes 
    Vantyghem, Marie Christine; de Koning, Eelco J.P.; Pattou, François; Rickels, Michael R. (Elsevier, 2019-10-05)
    The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to reduce disease complications. For some patients, technological approaches to insulin delivery are inadequate, and allogeneic ...