Note: Funding Information: Funding The work has been supported by The Leona M. and Harry B. Helmsley Charitable Trust, the Collaborative Research Consortium SFB1054 project A05 (DFG; SFB1054/2-A05), PID-NET (BMBF; 01GM1517A), BioSysNet (D2 - F5121.2 - 10c/12408), the Gottfried-Wilhelm-Leibniz Program (DFG; KL 877/11-1), Wilhelm Sander-Foundation, and the Care-for-Rare Foundation (ALL_140046). Olaf Groß received funding by the ERC Starting Grant (337689). Daniel Kotlarz has been a scholar funded by the Reinhard-Frank Stiftung (ACA_120028), Daimler und Benz Stiftung (32-06/16), and Else-Kröner-Fresenius-Stiftung (2015_A1550).