Appropriate shocks and mortality in patients with versus without diabetes with prophylactic implantable cardioverter defibrillators

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Appropriate shocks and mortality in patients with versus without diabetes with prophylactic implantable cardioverter defibrillators
 
Juhani Junttila, M.; Pelli, Ari; Kenttä, Tuomas V.; Friede, Tim; Willems, Rik; Bergau, Leonard; Malik, Marek; Vandenberk, Bert; Vos, Marc A.; Schmidt, Georg; Merkely, Bela; Lubinski, Andrzej; Svetlosak, Martin; Braunschweig, Frieder; Harden, Markus; Zabel, Markus; Huikuri, Heikki V.; Sticherling, Christian; for the EU-CERT-ICD Investigators
(2020) Diabetes Care, volume 43, issue 1, pp. 196 - 200
(Article)
Abstract
OBJECTIVE: Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to sudden death in diabetes are not well known. We compared the incidence of appropriate shocks and mortality in patients with versus without diabetes with a prophylactic implantable cardioverter defibrillator (ICD) included in ... read more
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Keywords: Advanced and Specialised Nursing, Internal Medicine, Endocrinology, Diabetes and Metabolism, Journal Article
DOI: https://doi.org/10.2337/dc19-1014
ISSN: 0149-5992
Publisher: American Diabetes Association Inc.
Note: Funding Information: The EU-CERT-ICD project is funded by the European Community’s 7th Framework Program FP7/2007–2013 (grant agreement number 602299). The prospective arm (clinicaltrials.gov NCT02064192) has enrolled 2,327 patients with an indication for a primary prevention ICD implantation who will also undergo an analysis of numerous candidate electrocardiogram variables from 12-lead Holter recordings as potential markers for a higher risk of malignant arrhythmias. Our data stem from an associated work package 02 within the project, a retrospective compilation of 14 locally existing registries of primary prevention ICD implantations between 2002 and 2014. The study design has already been described in Sticherl-ing et al. (10). In this analysis, we only consider data from 12 out of 14 centers, since diabetes status was only available for those centers (10). Diabetes was diagnosed according to the World Health Organization guidelines in all centers. Funding Information: Funding. The EU-CERT-ICD project is funded by the European Community’s 7th Framework Programme FP7/2007–2013 (grant agreement number 602299). Duality of Interest. No potential conflicts of interest relevant to this article were reported. Author Contributions. M.J.J. collected the patient population and wrote the manuscript. A.P. collected data and reviewed and edited the manuscript. T.V.K. and M.A.V. analyzed data and reviewed and edited the manuscript. T.F. and M.H. performed statistical analyses and reviewed and edited the manuscript. R.W., L.B., B.V., G.S., B.M., A.L., M.S., and F.B. collected the patient population and reviewed and edited the manuscript. M.M. analyzed data, reviewed grammar, and reviewed and edited the manuscript. M.Z. collected the patient population, supervised the project and funding, and reviewed and edited the manuscript. H.V.H. and C.S. supervised and collected the patient population and reviewed and edited the manuscript. T.F. and M.H. are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Prior Presentation. This study was presented in poster form at the 2018 European Society of Cardiology Congress, Munich, Germany, 25–29 August 2018, and the Heart Rhythm Society’s 39th Annual Scientific Sessions, Boston, MA, 9– 12 May 2018. Funding Information: The EU-CERT-ICD project is funded by the European Community's 7th Framework Programme FP7/2007-2013 (grant agreement number 602299). Publisher Copyright: © 2019 by the American Diabetes Association.
(Peer reviewed)