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UMC Repository: Recent submissions

  • Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study 
    Engelkes, Marjolein; Baan, Esme J; de Ridder, Maria A J; Svensson, Elisabeth; Prieto-Alhambra, Daniel; Lapi, Francesco; Giaquinto, Carlo; Picelli, Gino; Boudiaf, Nada; Albers, Frank; Evitt, Lee A; Cockle, Sarah; Bradford, Eric; Van Dyke, Melissa K; Suruki, Robert; Rijnbeek, Peter; Sturkenboom, Miriam C J M; Janssens, Hettie M; Verhamme, Katia M C (Blackwell Munksgaard, 2020-07-01)
    Background: There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related ...
  • Low value of second-look endoscopy for detecting residual colorectal cancer after endoscopic removal 
    Gijsbers, Kim M.; Post, Zoë; Schrauwen, Ruud W.M.; Tang, Thjon J.; Bisseling, Tanya M.; Bac, Dirk J.; Veenstra, Renzo P.; Schreuder, Ramon Michel; Epping Stippel, Ludger S.M.; de Vos tot Nederveen Cappel, Wouter H.; Slangen, Rob M.E.; van Lelyveld, Niels; Witteman, Ellen M.; van Milligen de Wit, Marc A.W.M.; Honkoop, Pieter; Alderlieste, Yasser; ter Borg, Pieter J.C.; van Roermund, Rolf; Schmittgens, Stephan; Dekker, Evelien; Leeuwenburgh, Ivonne; de Ridder, Rogier J.J.; Zonneveld, Anke M.; Hadithi, Muhammed; van Leerdam, Monique E.; Bruno, Marco J.; Vleggaar, Frank P.; Moons, Leon M.G.; Koch, Arjun D.; ter Borg, Frank (Mosby Inc., 2020-07)
    Background and Aims: Endoscopic resection is often feasible for submucosal invasive colorectal cancers (T1 CRCs) and usually judged as complete. If histology casts doubt on the radicality of resection margins, adjuvant ...
  • Oral squamous cell carcinoma involving the maxillae: Factors affecting local recurrence and the value of salvage treatment for overall survival 
    Slieker, Fons J B; de Bree, Remco; Van Cann, Ellen M (John Wiley & Sons Inc., 2020-08)
    OBJECTIVE: To determine factors associated with local recurrence (LR) of oral squamous cell carcinoma involving the maxillae (MSCC) and overall survival (OS) after salvage treatment. SUBJECTS AND METHODS: Retrospective ...
  • Integrated management of atrial fibrillation in primary care: results of the ALL-IN cluster randomized trial 
    van den Dries, Carline J; van Doorn, Sander; Rutten, Frans H; Oudega, Ruud; van de Leur, Sjef J C M; Elvan, Arif; Oude Grave, Lisa; Bilo, Henk J G; Moons, Karel G M; Hoes, Arno W; Geersing, Geert-Jan (Oxford University Press, 2020-08-07)
    Aims To evaluate whether integrated care for atrial fibrillation (AF) can be safely orchestrated in primary care. Methods The ALL-IN trial was a cluster randomized, open-label, pragmatic non-inferiority trial performed in ...
  • Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas 
    Hackeng, Wenzel M; Schelhaas, Willemien; Morsink, Folkert H M; Heidsma, Charlotte M; van Eeden, Susanne; Valk, Gerlof D; Vriens, Menno R; Heaphy, Christopher M; Nieveen van Dijkum, Els J M; Offerhaus, G Johan A; Dreijerink, Koen M A; Brosens, Lodewijk A A (Humana Press, 2020-06)
    Insulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally considered to be indolent tumors with an excellent prognosis after complete resection. However, some insulinomas have a poor prognosis ...
  • The association between changes in muscle mass and quality of life in patients with metastatic colorectal cancer 
    Derksen, Jeroen W G; Kurk, Sophie A; Peeters, Petra H M; Dorresteijn, Bram; Jourdan, Marion; van der Velden, Ankie M T; Nieboer, Peter; de Jong, Robert S; Honkoop, Aafke H; Punt, Cornelis J A; Koopman, Miriam; May, Anne M (Wiley-Blackwell, 2020-08)
    BACKGROUND: Skeletal muscle mass (SMM) loss is common in metastatic colorectal cancer (mCRC) patients and associated with poor clinical outcomes, including increased treatment-related toxicities and reduced survival. Muscle ...
  • R117H-CFTR function and response to VX-770 correlate with mRNA and protein expression in intestinal organoids 
    Van Mourik, Peter; van Haaren, Paul; Kruisselbrink, Evelien; Korkmaz, Cemil; Janssens, Hettie M.; de Winter – de Groot, Karin M.; van der Ent, Cornelis K.; Hagemeijer, Marne C.; Beekman, Jeffrey M. (Elsevier, 2020-09)
    Introduction: Variability in disease severity and CFTR modulator responses exists between patients with identical CFTR genotypes. Here, we characterized transcription, translation and function of R117H-CFTR using intestinal ...
  • Evaluation of clarity of the STOPP/START criteria for clinical applicability in prescribing for older people: A quality appraisal study 
    Sallevelt, Bastiaan Theodoor Gerard Marie; Huibers, Corlina Johanna Alida; Knol, Wilma; Puijenbroek, Eugene Van; Egberts, Toine; Wilting, Ingeborg (BMJ Publishing Group, 2020-02-18)
    Objectives Appropriate prescribing in older people continues to be challenging. Studies still report a high prevalence of inappropriate prescribing in older people. To reduce the problem of underprescribing and overprescribing ...
  • Difficulté de prédire la réponse clinique au méthotrexate chez les patients atteints de polyarthrite rhumatoïde: revue systématique de la littérature 
    Roodenrijs, Nadia M.T.; van der Goes, Marlies C.; Welsing, Paco M.J.; Tekstra, Janneke; van Laar, Jacob M.; Lafeber, Floris P.J.G.; Bijlsma, Johannes W.J.; Jacobs, Johannes W.G. (Elsevier Masson, 2020-05)
  • Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy 
    Safy-Khan, Mary; Jacobs, Johannes W.G.; De Hair, Maria J.H.; Welsing, Paco M.J.; Edwardes, Michael D.; Teitsma, Xavier M.; Luder, Yves; Devenport, Jenny; Van Laar, Jacob M.; Pethoe-Schramm, Attila; Bijlsma, Johannes W.J. (Elsevier, 2020-04)
    Background: In rheumatoid arthritis (RA) trials, inclusion of patients on background treatment with glucocorticoids (GCs) might impact efficacy and safety outcomes. Objectives: To determine if inclusion of patients on ...
  • Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces 
    Diloksumpan, Paweena; de Ruijter, Mylène; Castilho, Miguel; Gbureck, Uwe; Vermonden, Tina; van Weeren, P René; Malda, Jos; Levato, Riccardo (IOP Publishing Ltd., 2020-04)
    Multi-material 3D printing technologies that resolve features at different lengths down to the microscale open new avenues for regenerative medicine, particularly in the engineering of tissue interfaces. Herein, extrusion ...
  • Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity 
    Cui, Xiaolin; Soliman, Bram G.; Alcala-Orozco, Cesar R.; Li, Jun; Vis, Michelle A.M.; Santos, Miguel; Wise, Steven G.; Levato, Riccardo; Malda, Jos; Woodfield, Tim B.F.; Rnjak-Kovacina, Jelena; Lim, Khoon S. (John Wiley & Sons Inc., 2020-02)
    Silk fibroin hydrogels crosslinked through di-tyrosine bonds are clear, elastomeric constructs with immense potential in regenerative medicine applications. In this study, demonstrated is a new visible light-mediated ...
  • From Shape to Function: The Next Step in Bioprinting 
    Levato, Riccardo; Jungst, Tomasz; Scheuring, Ruben G.; Blunk, Torsten; Groll, Juergen; Malda, Jos (Wiley-Blackwell, 2020-03-01)
    In 2013, the “biofabrication window” was introduced to reflect the processing challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable materials that could serve as cell-laden bioinks, ...
  • Counselling in tuberous sclerosis complex: A survey on content and satisfaction in the Netherlands 
    Hulshof, Hanna M.; Brenner, Juliette; Overwater, Iris E.; Wit, Marie Claire de; Braun, Kees P.J.; Jansen, Floor E. (W.B. Saunders Ltd, 2020-03)
    Background: Tuberous sclerosis complex (TSC) is a highly variable condition and its clinical features cannot reliably be predicted from the genotype. Counselling of parents of a child with TSC is challenging because of the ...
  • Update on Drug Management of Refractory Epilepsy in Tuberous Sclerosis Complex 
    van der Poest Clement, Emma; Jansen, Floor E.; Braun, Kees P.J.; Peters, Jurriaan M. (Adis International Ltd, 2020-02-01)
    Tuberous sclerosis complex (TSC) is a genetic neurocutaneous disorder with epilepsy as a common and early presenting symptom. The neurological phenotype, however, is variable and unpredictable. Early and refractory seizures, ...
  • Does Intraoperative Cell Salvage Reduce Postoperative Infection Rates in Cardiac Surgery? 
    van Klarenbosch, Jan; van den Heuvel, Edwin R.; van Oeveren, Willem; de Vries, Adrianus J. (W.B. Saunders, 2020-06)
    Objective: Primary outcome was the risk for infections after cell salvage in cardiac surgery. Design: Data of a randomized controlled trial on cell salvage and filter use (ISRCTN58333401). Setting: Six cardiac surgery ...
  • A Ninhydrin-Type Urea Sorbent for the Development of a Wearable Artificial Kidney 
    Jong, Jacobus A W; Guo, Yong; Hazenbrink, Diënty; Douka, Stefania; Verdijk, Dennis; van der Zwan, Johan; Houben, Klaartje; Baldus, Marc; Scheiner, Karina C; Dalebout, Remco; Verhaar, Marianne C; Smakman, Robert; Hennink, Wim E; Gerritsen, Karin G F; van Nostrum, Cornelus F (Wiley-VCH Verlag, 2020-03-01)
    The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial ...
  • Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions 
    Jong, Jacobus A W; Guo, Yong; Veenhoven, Cas; Moret, Marc-Etienne; van der Zwan, Johan; Lucini Paioni, Alessandra; Baldus, Marc; Scheiner, Karina C; Dalebout, Remco; van Steenbergen, Mies J; Verhaar, Marianne C; Smakman, Robert; Hennink, Wim E; Gerritsen, Karin G F; van Nostrum, Cornelus F (American Chemical Society, 2020-02-14)
    For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on ...
  • A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex 
    Bruurmijn, Mark L C M; Schellekens, Wouter; Raemaekers, Mathijs A H; Ramsey, Nick F (Humana Press, 2020-04)
    For some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, ...
  • Processing of Targets and Non-targets in Verbal Working Memory 
    Schouwenaars, I T; de Dreu, M J; Rutten, G J M; Ramsey, N F; Jansma, J M (Elsevier Limited, 2020-03-01)
    In this study we used functional MRI (fMRI) to examine whether defining a stimulus as a target affects brain activation associated with a verbal working memory (WM) task. Seventeen healthy right-handed volunteers performed ...