From Shape to Function: The Next Step in Bioprinting
Levato, Riccardo; Jungst, Tomasz; Scheuring, Ruben G.; Blunk, Torsten; Groll, Juergen; Malda, Jos
(2020) Advanced materials, volume 32, issue 12
(Article)
Abstract
In 2013, the “biofabrication window” was introduced to reflect the processing challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable materials that could serve as cell-laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint. However, recent developments
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have now resulted in the availability of a plethora of bioinks, new printing approaches, and the technological advancement of established techniques. Nevertheless, it remains largely unknown which materials and technical parameters are essential for the fabrication of intrinsically hierarchical cell–material constructs that truly mimic biologically functional tissue. In order to achieve this, it is urged that the field now shift its focus from materials and technologies toward the biological development of the resulting constructs. Therefore, herein, the recent material and technological advances since the introduction of the biofabrication window are briefly summarized, i.e., approaches how to generate shape, to then focus the discussion on how to acquire the biological function within this context. In particular, a vision of how biological function can evolve from the possibility to determine shape is outlined.
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Keywords: biofabrication, bioinks, biological function, regenerative medicine, tissue hierarchy, General Materials Science, Mechanics of Materials, Mechanical Engineering
ISSN: 0935-9648
Publisher: Wiley-VCH Verlag
Note: Funding Information: R.L. and T.J. contributed equally to this work. R.L. and J.M. acknowledge the funding from the ReumaNederland (LLP‐12 and LLP‐22), the European Research Council (Grant Agreement No. 647426, 3DJOINT), and the Horizon 2020 Research and Innovation Program under the Grant Agreement No. 814444 (MEFISTO). R.L and J.M. also gratefully acknowledge the Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research (024.003.013). T.J., R.S., T.B., and J.G. thank the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for funding under the Collaborative Research Center SFB/TRR 225—project number 326998133—TRR 225 (subprojects A02, B04, and Z). J.G. further acknowledges the ERC (Grant Agreement No. 617989, Design2Heal) for financial support. The authors thank Daimon Hall (carbonandneon.com) for support with graphical design. Funding Information: R.L. and T.J. contributed equally to this work. R.L. and J.M. acknowledge the funding from the ReumaNederland (LLP-12 and LLP-22), the European Research Council (Grant Agreement No. 647426, 3DJOINT), and the Horizon 2020 Research and Innovation Program under the Grant Agreement No. 814444 (MEFISTO). R.L and J.M. also gratefully acknowledge the Gravitation Program ?Materials Driven Regeneration,? funded by the Netherlands Organization for Scientific Research (024.003.013). T.J., R.S., T.B., and J.G. thank the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for funding under the Collaborative Research Center SFB/TRR 225?project number 326998133?TRR 225 (subprojects A02, B04, and Z). J.G. further acknowledges the ERC (Grant Agreement No. 617989, Design2Heal) for financial support. The authors thank Daimon Hall (carbonandneon.com) for support with graphical design. Publisher Copyright: © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
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