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UMC Repository: Recent submissions

  • Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report) 
    Fedko, Iryna O; Hottenga, Jouke-Jan; Helmer, Quinta; Mbarek, Hamdi; Huider, Floris; Amin, Najaf; Beulens, Joline W; Bremmer, Marijke A; Elders, Petra J; Galesloot, Tessel E; Kiemeney, Lambertus A; van Loo, Hanna M; Picavet, H Susan J; Rutters, Femke; van der Spek, Ashley; van de Wiel, Anne M; van Duijn, Cornelia; de Geus, Eco J C; Feskens, Edith J M; Hartman, Catharina A; Oldehinkel, Albertine J; Smit, Jan H; Verschuren, W M Monique; Penninx, Brenda W J H; Boomsma, Dorret I; Bot, Mariska (Cambridge University Press, 2021-06)
    BACKGROUND: Major depressive disorder (MDD) is a common mood disorder, with a heritability of around 34%. Molecular genetic studies made significant progress and identified genetic markers associated with the risk of MDD; ...
  • Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples 
    CPCT Consortium (Springer Nature, 2020-03)
    Tumour mutational burden (TMB) has emerged as a promising biomarker to predict immune checkpoint inhibitors (ICIs) response in advanced solid cancers. However, harmonisation of TMB reporting by targeted gene panels is ...
  • What developments are needed to achieve less-invasive urodynamics? ICI-RS 2019 
    Gammie, Andrew; Speich, John E.; Damaser, Margot S.; Gajewski, Jerzy B.; Abrams, Paul; Rosier, Peter F.W.M.; Arlandis, Salvador; Tarcan, Tufan; Finazzi Agrò, Enrico (John Wiley & Sons Inc., 2020-07-01)
    Aims: To assess the state of technologies for urodynamics that are less invasive than standard cystometry and pressure-flow studies and to suggest areas needing research to improve this. Methods: A summary of a Think Tank ...
  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli 
    Genomics England Research Consortium (Nature Research, 2020-04)
    Various species of the intestinal microbiota have been associated with the development of colorectal cancer 1,2, but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. ...
  • Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke 
    von Berg, Joanna; van der Laan, Sander W; McArdle, Patrick F; Malik, Rainer; Kittner, Steven J; Mitchell, Braxton D; Worrall, Bradford B; de Ridder, Jeroen; Pulit, Sara L (Springer Nature, 2020-07)
    Ischemic stroke (IS), caused by obstruction of cerebral blood flow, is one of the leading causes of death. While neurologists agree on delineation of IS into three subtypes (cardioembolic stroke (CES), large artery stroke ...
  • The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme 
    Gayer-Anderson, Charlotte; Jongsma, Hannah E.; Di Forti, Marta; Quattrone, Diego; Velthorst, Eva; de Haan, Lieuwe; Selten, Jean-Paul; Szoke, Andrei; Llorca, Pierre-Michel; Tortelli, Andrea; Arango, Celso; Bobes, Julio; Bernardo, Miguel; Sanjuan, Julio; Santos, Jose Luis; Arrojo, Manuel; Parellada, Mara; Tarricone, Ilaria; Berardi, Domenico; Ruggeri, Mirella; Lasalvia, Antonio; Ferraro, Laura; La Cascia, Caterina; La Barbera, Daniele; Menezes, Paulo Rossi; Del-Ben, Cristina Marta; Rutten, Bart P.; van Os, Jim; Jones, Peter B.; Murray, Robin M.; Kirkbride, James B.; Morgan, Craig (D. Steinkopff-Verlag, 2020-05-01)
    PURPOSE: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) ...
  • The genetics of drug-related movement disorders, an umbrella review of meta-analyses 
    van der Burg, Nadine C; Al Hadithy, Asmar F Y; van Harten, Peter N; van Os, Jim; Bakker, P Roberto (Springer Nature, 2020-10)
    This umbrella review investigates which genetic factors are associated with drug-related movement disorders (DRMD), in an attempt to provide a synthesis of published evidence of candidate-gene studies. To identify all ...
  • Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness 
    Pries, L-K; Klingenberg, B; Menne-Lothmann, C; Decoster, J; van Winkel, R; Collip, D; Delespaul, P; De Hert, M; Derom, C; Thiery, E; Jacobs, N; Wichers, M; Cinar, O; Lin, B D; Luykx, J J; Rutten, B P F; van Os, J; Guloksuz, S (Wiley-Blackwell, 2020-05)
    OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle ...
  • To continue or not to continue?: Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial 
    Begemann, Marieke J.H.; Thompson, Ilse A.; Veling, Wim; Gangadin, Shiral S.; Geraets, Chris N.W.; Van 'T Hag, Erna; Müller-Kuperus, Sanne J.; Oomen, Priscilla P.; Voppel, Alban E.; Van Der Gaag, Mark; Kikkert, Martijn J.; Van Os, Jim; Smit, H. Filip E.; Knegtering, Rikus H.; Wiersma, Sybren; Stouten, Luyken H.; Gijsman, Harm J.; Wunderink, Lex; Staring, Anton B.P.; Veerman, Selene R.T.; Mahabir, Amrita G.S.; Kurkamp, Jörg; Pijnenborg, Gerdina H.M.; Veen, Natalie D.; Marcelis, Machteld; Grootens, Koen P.; Faber, Gunnar; Van Beveren, Nico J.; Been, Agaath; Van Den Brink, Truus; Bak, Maarten; Van Amelsvoort, Therese A.M.J.; Ruissen, Andrea; Blanke, Christine; Groen, Karin; De Haan, Lieuwe; Sommer, Iris E.C. (BioMed Central, 2020-02-07)
    Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and ...
  • Psychotic Experiences Are Associated With Paternal Age But Not With Delayed Fatherhood in a Large, Multinational, Community Sample 
    EU-GEI WP2 Group Author (Oxford University Press, 2020-09)
    Advanced paternal age has been consistently associated with an increased risk of schizophrenia. It is less known if such an association also exists with subclinical/attenuated forms of psychosis. Additionally, it has been ...
  • Measuring resilience prospectively as the speed of affect recovery in daily life: A complex systems perspective on mental health 
    Kuranova, Anna; Booij, Sanne H.; Menne-Lothmann, Claudia; Decoster, Jeroen; Van Winkel, Ruud; Delespaul, Philippe; De Hert, Marc; Derom, Catherine; Thiery, Evert; Rutten, Bart P.F.; Jacobs, Nele; Van Os, Jim; Wigman, Johanna T.W.; Wichers, Marieke (BioMed Central Ltd., 2020-02-18)
    Introduction: There is growing evidence that mental disorders behave like complex dynamic systems. Complex dynamic systems theory states that a slower recovery from small perturbations indicates a loss of resilience of a ...
  • Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis 
    EU-GEI High Risk Study (Oxford University Press, 2020-07)
    OBJECTIVE: To investigate the association between facial affect recognition (FAR) and type of adverse childhood experiences (ACEs) in a sample of clinical high risk (CHR) individuals and a matched sample of healthy controls ...
  • Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder 
    van Haren, Neeltje E M; Setiaman, Nikita; Koevoets, Martijn G J C; Baalbergen, Heleen; Kahn, Rene S; Hillegers, Manon H J (Cambridge University Press, 2020-01-31)
    BACKGROUND.: Studying offspring of schizophrenia (SZo) and bipolar disorder patients (BDo) provides important information on the putative neurodevelopmental trajectories underlying development toward severe mental illnesses. ...
  • Two distinc neuroanatomica subtypes of schizophrenia revealed using machine learning 
    Chand, Ganesh B.; Dwyer, Dominic B.; Erus, Guray; Sotiras, Aristeidis; Varol, Erdem; Srinivasan, Dhivya; Doshi, Jimit; Pomponio, Raymond; Pigoni, Alessandro; Dazzan, Paola; Kahn, Rene S.; Schnack, Hugo G.; Zanetti, Marcus V.; Meisenzahl, Eva; Busatto, Geraldo F.; Crespo-Facorro, Benedicto; Pantelis, Christos; Wood, Stephen J.; Zhuo, Chuanjun; Shinohara, Russell T.; Shou, Haochang; Fan, Yong; Gur, Ruben C.; Gur, Raquel E.; Satterthwaite, Theodore D.; Koutsouleris, Nikolaos; Wolf, Daniel H.; Davatzikos, Christos (Oxford University Press, 2020-03-01)
    Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic cohort, using novel semi-supervised machine ...
  • Long-Term Effects of Radioiodine Treatment on Female Fertility in Survivors of Childhood Differentiated Thyroid Carcinoma 
    Nies, Marloes; Cantineau, Astrid E P; Arts, Eus G J M; van den Berg, Marleen H; van Leeuwen, Flora E; Muller Kobold, Anneke C; Klein Hesselink, Mariëlle Sanne; Burgerhof, Johannes G M; Brouwers, Adrienne H; van Dam, Eveline W C M; Havekes, Bas; van den Heuvel-Eibrink, Marry M; Corssmit, Eleonora P M; Kremer, Leontien C M; Netea-Maier, Romana; van der Pal, Heleen J H; Peeters, Robin P; Plukker, John Th M; Ronckers, Cecile M; van Santen, Hanneke M; van der Horst-Schrivers, Anouk N A; Tissing, Wim J E; Bocca, Gianni; van Dulmen-den Broeder, Eline; Links, Thera P (Mary Ann Liebert Inc., 2020-08-01)
    Background: Differentiated thyroid carcinoma (DTC) during childhood is a rare disease. Its excellent survival rate requires a focus on possible long-term adverse effects. This study aimed to evaluate fertility in female ...
  • Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease 
    Kruitwagen, Hedwig S; Oosterhoff, Loes A; van Wolferen, Monique E; Chen, Chen; Nantasanti Assawarachan, Sathidpak; Schneeberger, Kerstin; Kummeling, Anne; van Straten, Giora; Akkerdaas, Ies C; Vinke, Christel R; van Steenbeek, Frank G; van Bruggen, Leonie W L; Wolfswinkel, Jeannette; Grinwis, Guy C M; Fuchs, Sabine A; Gehart, Helmuth; Geijsen, Niels; Vries, Robert G; Clevers, Hans; Rothuizen, Jan; Schotanus, Baukje A; Penning, Louis C; Spee, Bart (Multidisciplinary Digital Publishing Institute (MDPI), 2020-02-11)
    The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation. Unfortunately, ...
  • Value of an outpatient transition clinic for young people with inflammatory bowel disease: A mixed-methods evaluation 
    Sattoe, Jane N.T.; Peeters, Mariëlle A.C.; Haitsma, Jannie; Van Staa, Anne Loes; Wolters, Victorien M.; Escher, Johanna C. (BMJ Publishing Group, 2020-01-06)
    Objective: Developing and evaluating effective transition interventions for young people (16-25 years) with inflammatory bowel disease (IBD) is a high priority. While transition clinics (TCs) have been recommended, little ...
  • Availability, accessibility and delivery to patients of the 28 orphan medicines approved by the European Medicine Agency for hereditary metabolic diseases in the MetabERN network 
    Heard, Jean Michel; Vrinten, Charlotte; Schlander, Michael; Bellettato, Cinzia Maria; Van Lingen, Corine; Scarpa, Maurizio; MetabERN collaboration group (BioMed Central, 2020-01-06)
    Background: The European Medicine Agency granted marketing approval to 164 orphan medicinal products for rare diseases, among which 28 products intended for the treatment of hereditary metabolic diseases. Taking advantage ...
  • Correction to:: Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance (Osteoporosis International, (2019), 10.1007/s00198-019-05181-6) 
    Berencsi, K; Sami, A; Ali, M S; Marinier, K; Deltour, N; Perez-Gutthann, S; Pedersen, L; Rijnbeek, P; Van der Lei, J; Lapi, F; Simonetti, M; Reyes, C; Sturkenboom, M C J M; Prieto-Alhambra, D (Springer Science and Business Media Deutschland GmbH, 2020-04-01)
    The original version of this article, published on 26 November 2019 contained a mistake. An author’s name was misspelled. The correct author name reads as follows: Susana Perez-Gutthann. The original article has been corrected.
  • ADVANCE database characterisation and fit for purpose assessment for multi-country studies on the coverage, benefits and risks of pertussis vaccinations 
    Sturkenboom, Miriam; Braeye, Toon; van der Aa, Lieke; Danieli, Giorgia; Dodd, Caitlin; Duarte-Salles, Talita; Emborg, Hanne-Dorthe; Gheorghe, Marius; Kahlert, Johnny; Gini, Rosa; Huerta, Consuelo; Martín-Merino, Elisa; McGee, Chris; de Lusignan, Simon; Picelli, Gino; Roberto, Giuseppe; Tramontan, Lara; Villa, Marco; Weibel, Daniel; Titievsky, Lina (Elsevier, 2020-12-22)
    INTRODUCTION: The public-private ADVANCE consortium (Accelerated development of vaccine benefit-risk collaboration in Europe) aimed to assess if electronic healthcare databases can provide fit-for purpose data for ...