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Type and Extent of Information on (Potentially Critical) Quality Attributes Described in European Public Assessment Reports for Adalimumab Biosimilars

Alsamil, Ali M; Giezen, Thijs J; Egberts, Toine C; Leufkens, Hubert G; Gardarsdottir, Helga (Multidisciplinary Digital Publishing Institute, 2021-03)

Regulatory approval of biosimilars predominantly relies on biosimilarity assessments of quality attributes (QAs), particularly the potentially critical QAs (pCQAs) that may affect the clinical profile. However, a limited ...
Chronic social stress lessens the metabolic effects induced by a high-fat diet

Jene, Tanja; Ruiz de Azua, Inigo; Hasch, Annika; Klüpfel, Jennifer; Deuster, Julia; Maas, Mirjam; Nijboer, Cora H; Lutz, Beat; Müller, Marianne B; van der Kooij, Michael A (BioScientifica Ltd., 2021-04-01)

Stress has a major impact on the modulation of metabolism, as previously evidenced by hyperglycemia following chronic social defeat (CSD) stress in mice. Although CSD-triggered metabolic dysregulation might predispose to ...
In memoriam-Larry J. Siever, M.D

Davis, Kenneth L; Kahn, René S; New, Antonia; Aronson, Andrew (Springer Nature, 2021-06)
A normative chart for cognitive development in a genetically selected population

Fiksinski, Ania M; Bearden, Carrie E; Bassett, Anne S; Kahn, Rene S; Zinkstok, Janneke R; Hooper, Stephen R; Tempelaar, Wanda; Vorstman, Jacob A S; Breetvelt, Elemi J; 22q11DS International Consortium on Brain and Behavior (Springer Nature, 2022-06)

Certain pathogenic genetic variants impact neurodevelopment and cause deviations from typical cognitive trajectories. Understanding variant-specific cognitive trajectories is clinically important for informed monitoring ...
Should patients with low-risk renal cell carcinoma be followed differently after nephron-sparing surgery vs radical nephrectomy?

Abu-Ghanem, Y; Powles, T; Capitanio, U; Beisland, C; Järvinen, P; Stewart, G D; Gudmundsson, E; Lam, Tbl; Marconi, L; Fernandéz-Pello, S; Nisen, H; Meijer, R P; Volpe, A; Ljungberg, B; Klatte, T; Bensalah, Karim; Dabestani, S; Bex, A (Wiley-Blackwell, 2021-09)

Objective: To investigate whether pT1 renal cell carcinoma (RCC) should be followed differently after partial (PN) or radical nephrectomy (RN) based on a retrospective analysis of a multicentre database (RECUR). Subjects: ...
Jumping on base editing to repair the diseased cardiovascular system in vivo

Gladka, Monika M; Baker, Andrew H (Oxford University Press, 2021-04-01)
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Ponsioen, Bas; Post, Jasmin B; Buissant des Amorie, Julian R; Laskaris, Dimitrios; van Ineveld, Ravian L; Kersten, Simone; Bertotti, Andrea; Sassi, Francesco; Sipieter, François; Cappe, Benjamin; Mertens, Sander; Verlaan-Klink, Ingrid; Boj, Sylvia F; Vries, Rob G J; Rehmann, Holger; Vandenabeele, Peter; Riquet, Franck B; Trusolino, Livio; Bos, Johannes L; Snippert, Hugo J G (Nature Research, 2021-04)

Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, ...
Single-Cell RNA Sequencing of the Adult Mammalian Heart - State of the Art and Future Perspectives (vol 18, pg 64, 2021): Single-Cell RNA Sequencing of the Adult Mammalian Heart – State of the Art and Future Perspectives (Current Heart Failure Reports, (2021), 18, 2, (64-70), 10.1007/s11897-021-00504-3)

Gladka, Monika M (Current Science, Inc., 2021-12)

A Correction to this paper has been published: https://doi.org/10.1007/s11897-021-00507-0.
A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

van Oostrom, Marek J; Meijer, Wilke H M; Sonnen, Katharina F (MYJoVE Corporation, 2021-03-19)

Periodic segmentation of the presomitic mesoderm of a developing mouse embryo is controlled by a network of signaling pathways. Signaling oscillations and gradients are thought to control the timing and spacing of segment ...
The frontier of live tissue imaging across space and time

Huang, Qiang; Garrett, Aliesha; Bose, Shree; Blocker, Stephanie; Rios, Anne C; Clevers, Hans; Shen, Xiling (Cell Press, 2021-04-01)

What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. ...
The interplay between drivers of erythropoiesis and iron homeostasis in rare hereditary anemias: Tipping the balance

Grootendorst, Simon; de Wilde, Jonathan; van Dooijeweert, Birgit; van Vuren, Annelies; van Solinge, Wouter; Schutgens, Roger; van Wijk, Richard; Bartels, Marije (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-02)

Rare hereditary anemias (RHA) represent a group of disorders characterized by either impaired production of erythrocytes or decreased survival (i.e., hemolysis). In RHA, the regulation of iron metabolism and erythropoiesis ...
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Microbleeds International Collaborative Network (Elsevier Limited, 2021-04)

BACKGROUND: Balancing the risks of recurrent ischaemic stroke and intracranial haemorrhage is important for patients treated with antithrombotic therapy after ischaemic stroke or transient ischaemic attack. However, existing ...
Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

Muntjewerff, Elke M; Tang, Kechun; Lutter, Lisanne; Christoffersson, Gustaf; Nicolasen, Mara J T; Gao, Hong; Katkar, Gajanan D; Das, Soumita; Ter Beest, Martin; Ying, Wei; Ghosh, Pradipta; Aidy, Sahar El; Oldenburg, Bas; van den Bogaart, Geert; Mahata, Sushil K (Wiley, 2021-06)

AIM: A "leaky" gut barrier has been implicated in the initiation and progression of a multitude of diseases, for example, inflammatory bowel disease (IBD), irritable bowel syndrome and celiac disease. Here we show how ...
Maternal and neonatal bleeding complications in relation to peripartum management in hemophilia carriers: A systematic review

Punt, M. C.; Waning, M. L.; Mauser-Bunschoten, E. P.; Kruip, M. J.H.A.; Eikenboom, J.; Nieuwenhuizen, L.; Makelburg, A. B.U.; Driessens, M. H.E.; Duvekot, J. J.; Peters, M.; Middeldorp, J. M.; Bloemenkamp, K. W.M.; Schutgens, R. E.G.; Lely, A. T.; van Galen, K. P.M. (Churchill Livingstone, 2021-09)

Currently, there is no consensus on the optimal management to prevent postpartum hemorrhage (PPH) in hemophilia carriers. We aimed to evaluate peripartum management strategies in relation to maternal and neonatal bleeding ...
Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Crockett, Cathryn B; Samson, Pamela; Chuter, Robert; Dubec, Michael; Faivre-Finn, Corinne; Green, Olga L; Hackett, Sara L; McDonald, Fiona; Robinson, Clifford; Shiarli, Anna-Maria; Straza, Michael W; Verhoeff, Joost J C; Werner-Wasik, Maria; Vlacich, Gregory; Cobben, David (Frontiers Media S. A., 2021-03-10)

Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which ...
Sarcoma of the Heart Treated with Stereotactic MR-Guided Online Adaptive Radiation Therapy

Pomp, Jacquelien; van Asselen, Bram; Tersteeg, Robbert H A; Vink, Aryan; Hassink, Rutger J; van der Kaaij, Niels P; van Aarnhem, Guido E E H L; Verhoeff, Joost J C (S. Karger AG, 2021-04-02)

We present the first case in the literature of a patient with a histology-proven intimal sarcoma of the heart, recurrent after surgery, treated with stereotactic MR-guided online adaptive radiation therapy on an MR-Linac ...
Long-term treated HIV infection is associated with platelet mitochondrial dysfunction

van der Heijden, Wouter A.; van de Wijer, Lisa; Jaeger, Martin; Grintjes, Karin; Netea, Mihai G.; Urbanus, Rolf T.; van Crevel, Reinout; van den Heuvel, Lambertus P.; Brink, Maaike; Rodenburg, Richard J.; de Groot, Philip G.; van der Ven, Andre J.; de Mast, Quirijn (Nature Publishing Group, 2021-03-18)

HIV infection and antiretroviral therapy have been linked to mitochondrial dysfunction. The role of platelet mitochondrial dysfunction in thrombosis, immunoregulation and age-related diseases is increasingly appreciated. ...
Clinical and Molecular Characteristics and Outcome of Cystic Partially Differentiated Nephroblastoma and Cystic Nephroma: A Narrative Review of the Literature

van Peer, Sophie E; Pleijte, Corine J H; de Krijger, Ronald R; Jongmans, Marjolijn C J; Kuiper, Roland P; Lilien, Marc R; van Grotel, Martine; Graf, Norbert; van den Heuvel-Eibrink, Marry M; Hol, Janna A (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03-01)

In children presenting with a predominantly cystic renal tumor, the most likely diagnoses include cystic partially differentiated nephroblastoma (CPDN) and cystic nephroma (CN). Both entities are rare and limited information ...
Poor compliance of clinical trial registration among trials included in systematic reviews: a cohort study

Lindsley, Kristina; Fusco, Nicole; Teeuw, Hannah; Mooij, Eva; Scholten, Rob; Hooft, Lotty (Elsevier, 2021-04)

OBJECTIVES: The objective of the study was to examine whether clinical trials that have been included in systematic reviews have been registered in clinical trial registers and, when they have, whether results of the trials ...
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease

Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2020-07-07)

BACKGROUND: Some people with SARS-CoV-2 infection remain asymptomatic, whilst in others the infection can cause mild to moderate COVID-19 disease and COVID-19 pneumonia, leading some patients to require intensive care ...

Now showing items 16561-16580 of 40729