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Preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts): checklist, explanation, and elaboration

Cohen, Jérémie F; Deeks, Jonathan J; Hooft, Lotty; Salameh, Jean-Paul; Korevaar, Daniël A; Gatsonis, Constantine; Hopewell, Sally; Hunt, Harriet A; Hyde, Chris J; Leeflang, Mariska M; Macaskill, Petra; McGrath, Trevor A; Moher, David; Reitsma, Johannes B; Rutjes, Anne W S; Takwoingi, Yemisi; Tonelli, Marcello; Whiting, Penny; Willis, Brian H; Thombs, Brett; Bossuyt, Patrick M; McInnes, Matthew D F (BMJ Publishing Group, 2021-03-15)

For many users of the biomedical literature, abstracts may be the only source of information about a study. Hence, abstracts should allow readers to evaluate the objectives, key design features, and main results of the ...
Barriers and facilitators to reduce low-value care: a qualitative evidence synthesis

van Dulmen, S A; Naaktgeboren, C A; Heus, Pauline; Verkerk, Eva W; Weenink, J; Kool, Rudolf Bertijn; Hooft, Lotty (BMJ Publishing Group, 2020-10-30)

OBJECTIVE: To assess barriers and facilitators to de-implementation. DESIGN: A qualitative evidence synthesis with a framework analysis. DATA SOURCES: Medline, Embase, Cochrane Library and Rx for Change databases until ...
Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection

Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2021-03-24)

Background: Accurate rapid diagnostic tests for SARS-CoV-2 infection could contribute to clinical and public health strategies to manage the COVID-19 pandemic. Point-of-care antigen and molecular tests to detect current ...
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19

Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2021-02-23)

Background: The clinical implications of SARS-CoV-2 infection are highly variable. Some people with SARS-CoV-2 infection remain asymptomatic, whilst the infection can cause mild to moderate COVID-19 and COVID-19 pneumonia ...
Reducing Inappropriate Proton Pump Inhibitors Use for Stress Ulcer Prophylaxis in Hospitalized Patients: Systematic Review of De-Implementation Studies

Orelio, Claudia C; Heus, Pauline; Kroese-van Dieren, Judith J; Spijker, René; van Munster, Barbara C; Hooft, Lotty (Springer New York, 2021-07)

BACKGROUND: A large proportion of proton pump inhibitor (PPI) prescriptions, including those for stress ulcer prophylaxis (SUP), are inappropriate. Our study purpose was to systematically review the effectiveness of ...
Clinical outcome of patients with metastatic melanoma of unknown primary in the era of novel therapy

Verver, Danielle; Grünhagen, Dirk J; van Akkooi, Alexander C J; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; van den Eertwegh, Alfonsus J M; de Groot, Jan Willem B; Boers-Sonderen, Marye J; Haanen, John B A G; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Rozemarijn S; Suijkerbuijk, Karijn P M; Tije, Albert J Ten; Vreugdenhil, Gerard; Verhoef, Cornelis; van der Veldt, Astrid A M (Springer Science and Business Media Deutschland GmbH, 2021-11)

Melanoma of unknown primary (MUP) is considered different from melanoma of known primary (MKP), and it is unclear whether these patients benefit equally from novel therapies. In the current study, characteristics and overall ...
Effects of 12 weeks of recreational football (soccer) with caloric control on glycemia and cardiovascular health of adolescent boys with type 1 diabetes

Mohammed, Mohammed Hamdan Hashem; Al-Qahtani, Mohammad Hussain Hassan; Takken, Tim (John Wiley & Sons Inc., 2021-06)

Objective: To determine the effects of recreational football combined with caloric control on glycemia and cardiovascular health of adolescent boys with type 1 diabetes. Background: Though 12 weeks of physical activity ...
Checkpoint inhibition: protecting against or predisposing for second primary tumors?

Suijkerbuijk, K P M; May, A M; van Eijs, M J M (Oxford University Press, 2021-07)
Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells

Widowski, Helene; Reynaert, Niki L.; Ophelders, Daan R.M.G.; Hütten, Matthias C.; Nikkels, Peter G.J.; Severens-Rijvers, Carmen A.H.; Cleutjens, Jack P.M.; Kemp, Matthew W.; Newnham, John P.; Saito, Masatoshi; Usuda, Haruo; Payne, Matthew S.; Jobe, Alan H.; Kramer, Boris W.; Delhaas, Tammo; Wolfs, Tim G.A.M. (Frontiers Media S. A., 2021-02-22)

Perinatal inflammatory stress is strongly associated with adverse pulmonary outcomes after preterm birth. Antenatal infections are an essential perinatal stress factor and contribute to preterm delivery, induction of lung ...
Optimization of negative stage bias potential for faster imaging in large-scale electron microscopy

Lane, Ryan; Vos, Yoram; Wolters, Anouk H G; Kessel, Luc van; Chen, S Elisa; Liv, Nalan; Klumperman, Judith; Giepmans, Ben N G; Hoogenboom, Jacob P (Academic Press Inc., 2021-01)

Large-scale electron microscopy (EM) allows analysis of both tissues and macromolecules in a semi-automated manner, but acquisition rate forms a bottleneck. We reasoned that a negative bias potential may be used to enhance ...
What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings

Ham, RMT; Hovels, Anke M.; Hoekman, J.; Frederix, GW; Leufkens, H.G.M.; Klungel, Olaf; Jedema, I.; Nikolic, T.; van Pel, M.; Zwaginga, J.J.; de Goede, A.; Schreibelt, Gerty; de Vries, I Jolanda M; Dolstra, Harry; Ovelgonne, H; Meij, P; Mountford, J.C.; Turner, M.L; Hoefnagel, MHN (Informa Healthcare, 2020-07)

Background aims: Recent technical and clinical advances with cell-based therapies (CBTs) hold great promise in the treatment of patients with rare diseases and those with high unmet medical need. Currently the majority of ...
A Review of Methodological Considerations for Economic Evaluations of Gene Therapies and Their Application in Literature

ten Ham, RMT; Klungel, Olaf; Leufkens, H.G.M.; Frederix, GWJ (Elsevier Limited, 2020-09)

Objectives: To identify methodological considerations discussed in literature addressing economic evaluations (EEs) of gene therapies (GTs). Additionally, we assessed if these considerations are applied in published GT EEs ...
Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus

Schäfer, Carmen B; Gao, Zhenyu; De Zeeuw, Chris I; Hoebeek, Freek E (Wiley-Blackwell, 2021-04-01)

KEY POINTS: Ventrolateral thalamus (VL) integrates information from cerebellar nuclei and motor cortical layer VI. Inputs from the cerebellar nuclei evoke large-amplitude responses that depress upon repetitive stimulation ...
Thoracic imaging tests for the diagnosis of COVID-19

Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2021-03-16)

BACKGROUND: The respiratory illness caused by SARS-CoV-2 infection continues to present diagnostic challenges. Our 2020 edition of this review showed thoracic (chest) imaging to be sensitive and moderately specific in the ...
Sexual health counselling by Dutch HIV care providers: A cross-sectional survey among physicians and nurses in the Netherlands

Munnik, Suzanne de; Vervoort, Sigrid C J M; Kraan, Liza; Ammerlaan, Heidi S M; Grondhuis Palacio, Lorena A; Kok, Gerjo; Elzevier, Henk W; de Wit, John; Daas, Chantal den (Routledge, 2022-06)

To improve sexual health among people living with HIV, sexual health should be addressed during consultations in routine HIV care. The aim of the present study was to investigate to what extent Sexual Health Counselling ...
Guidance for the design and reporting of studies evaluating the clinical performance of tests for present or past SARS-CoV-2 infection

Doust, Jenny A; Bell, Katy J L; Leeflang, Mariska M G; Dinnes, Jacqueline; Lord, Sally J; Mallett, Sue; van de Wijgert, Janneke H H M; Sandberg, Sverre; Adeli, Khosrow; Deeks, Jonathan J; Bossuyt, Patrick M; Horvath, Andrea R (BMJ Publishing Group, 2021-03-29)

Testing for SARS-CoV-2 infection is key in managing the current pandemic. More than 1700 preprints and peer reviewed journal articles evaluating tests for SARS-CoV-2 infection have been published as of January 2021. However, ...
Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

Zimmer, Till S; Korotkov, Anatoly; Zwakenberg, Susan; Jansen, Floor E; Zwartkruis, Fried J T; Rensing, Nicholas R; Wong, Michael; Mühlebner, Angelika; van Vliet, Erwin A; Aronica, Eleonora; Mills, James D (Wiley-Blackwell, 2021-09)

Tuberous sclerosis complex (TSC) is a congenital disorder characterized by cortical malformations and concomitant epilepsy caused by loss-of-function mutations in the mTOR suppressors TSC1 or TSC2. While the underlying ...
Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective

Mohammad, Khorshid; Scott, James N; Leijser, Lara M; Zein, Hussein; Afifi, Jehier; Piedboeuf, Bruno; de Vries, Linda S; van Wezel-Meijler, Gerda; Lee, Shoo K; Shah, Prakesh S (Frontiers Media S. A., 2021-03-08)

Acquired brain injury remains common in very preterm infants and is associated with significant risks for short- and long-term morbidities. Cranial ultrasound has been widely adopted as the first-line neuroimaging modality ...
Monitoring Immune Responses in Neuroblastoma Patients during Therapy

Szanto, Celina L; Cornel, Annelisa M; Vijver, Saskia V; Nierkens, Stefan (Multidisciplinary Digital Publishing Institute (MDPI), 2020-02-24)

Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood. Despite intense treatment, children with this high-risk disease have a poor prognosis. Immunotherapy showed a significant improvement in event-free ...
Analytical techniques for multiplex analysis of protein biomarkers

Van Gool, Alain; Corrales, Fernado; Čolović, Mirjana; Krstić, Danijela; Oliver-Martos, Begona; Martínez-Cáceres, Eva; Jakasa, Ivone; Gajski, Goran; Brun, Virginie; Kyriacou, Kyriacos; Burzynska-Pedziwiatr, Izabela; Wozniak, Lucyna Alicja; Nierkens, Stephan; Pascual García, César; Katrlik, Jaroslav; Bojic-Trbojevic, Zanka; Vacek, Jan; Llorente, Alicia; Antohe, Felicia; Suica, Viorel; Suarez, Guillaume; t'Kindt, Ruben; Martin, Petra; Penque, Deborah; Martins, Ines Lanca; Bodoki, Ede; Iacob, Bogdan-Cezar; Aydindogan, Eda; Timur, Suna; Allinson, John; Sutton, Christopher; Luider, Theo; Wittfooth, Saara; Sammar, Marei (Taylor and Francis Ltd., 2020-04-02)

INTRODUCTION: The importance of biomarkers for pharmaceutical drug development and clinical diagnostics is more significant than ever in the current shift toward personalized medicine. Biomarkers have taken a central ...

Now showing items 16581-16600 of 40729