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Now showing items 16541-16560 of 40728

Diagnostic performance and clinical implications for enhancing a hybrid quantitative flow ratio-FFR revascularization decision-making strategy

Peper, Joyce; van Hamersvelt, Robbert W; Rensing, Benno J W M; van Kuijk, Jan-Peter; Voskuil, Michiel; Berg, Jurriën M Ten; Schaap, Jeroen; Kelder, Johannes C; Grobbee, Diederick E; Leiner, Tim; Swaans, Martin J (Nature Publishing Group, 2021-03-19)

Invasive fractional flow reserve (FFR) adoption remains low mainly due to procedural and operator related factors as well as costs. Alternatively, quantitative flow ratio (QFR) achieves a high accuracy mainly outside the ...
Diagnostic Performance of On-Site Coronary CT Angiography-derived Fractional Flow Reserve Based on Patient-specific Lumped Parameter Models

van Hamersvelt, Robbert W; Voskuil, Michiel; de Jong, Pim A; Willemink, Martin J; Išgum, Ivana; Leiner, Tim (Radiological Society of North America Inc., 2019-10)

Purpose To evaluate the diagnostic performance of a prototype on-site coronary CT angiography–derived fractional flow reserve (CT FFR) algorithm, based on patient-specific lumped parameter models, for the detection of ...
Clinical outcomes after permanent polymer or polymer-free stent implantation in patients with diabetes mellitus: The ReCre8 diabetes substudy

ReCre8 Study Investigators (John Wiley & Sons Inc., 2022-02-01)

OBJECTIVES: The purpose of this analysis was to compare target-lesion failure (TLF) of a permanent polymer zotarolimus-eluting stent (PP-ZES) versus a polymer-free amphilimus-eluting stent (PF-AES) in diabetics. BACKGROUND: ...
An anomaly detection approach to identify chronic brain infarcts on MRI

van Hespen, Kees M; Zwanenburg, Jaco J M; Dankbaar, Jan W; Geerlings, Mirjam I; Hendrikse, Jeroen; Kuijf, Hugo J (Nature Publishing Group, 2021-12)

The performance of current machine learning methods to detect heterogeneous pathology is limited by the quantity and quality of pathology in medical images. A possible solution is anomaly detection; an approach that can ...
Supervised exercise after oesophageal cancer surgery: the PERFECT multicentre randomized clinical trial

van Vulpen, J K; Hiensch, A E; van Hillegersberg, R; Ruurda, J P; Backx, F J G; Nieuwenhuijzen, G A P; Kouwenhoven, E A; Groenendijk, R P R; van der Peet, D L; Hazebroek, E J; Rosman, C; Wijnhoven, B P L; van Berge Henegouwen, Mark I; van Laarhoven, H W M; Siersema, PD; May, A M (John Wiley & Sons Inc., 2021-07-23)

Background: This study investigated whether a supervised exercise programme improves quality of life (QoL), fatigue and cardiorespiratory fitness in patients in the first year after oesophagectomy. Methods: The multicentre ...
Fatigue among children with a chronic disease: A cross-sectional study

Nap-Van Der Vlist, Merel M.; Dalmeijer, Geertje W.; Grootenhuis, Martha A.; Van Der Ent, Kors; Van Den Heuvel-Eibrink, Marry M.; Swart, Joost F.; Van De Putte, Elise M.; Nijhof, Sanne L. (BMJ Publishing Group, 2021-02-17)

Objective To determine: (1) which biological/lifestyle, psychological and/or social factors are associated with fatigue among children with a chronic disease and (2) how much each of these factors contributes to explaining ...
Severe Fatigue Is Common Among Pediatric Patients with Primary Immunodeficiency and Is Not Related to Disease Activity

Nijhof, Linde N; van Brussel, Marco; Pots, Esther M; van Litsenburg, Raphaële R L; van de Putte, Elise M; van Montfrans, Joris M; Nijhof, Sanne L (Springer New York, 2021-08)

PURPOSE: Fatigue is a distressing symptom commonly reported among pediatric patients with primary immunodeficiency (PID). However, the relationship between fatigue and disease activity is currently unknown. METHODS: In ...
Statins After Ischemic Stroke in the Oldest: A Cohort Study Using the Clinical Practice Research Datalink Database

Lefeber, Geert J; Knol, Wilma; Souverein, Patrick C; Bouvy, Marcel L; de Boer, Anthonius; Koek, Huiberdina L (Lippincott Williams & Wilkins, 2021-04)

Background and Purpose: Statins are frequently initiated in patients aged 80 years and older after an ischemic stroke, even though evidence on prevention of recurrent cardiovascular disease is scarce. In this study, we ...
Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis

The Blood Pressure Lowering Treatment Trialists' Collaboration (Elsevier Limited, 2021-04)

Background: Some studies have suggested a link between antihypertensive medication and cancer, but the evidence is so far inconclusive. Thus, we aimed to investigate this association in a large individual patient data ...
Mini-gut feelings: Perspectives of people with cystic fibrosis on the ethics and governance of organoid biobanking

Lensink, Michael A.; Boers, Sarah N.; M Gulmans, Vincent A.; Jongsma, Karin R.; Bredenoord, Annelien L. (Taylor and Francis Ltd., 2021-05)

Aim: Organoid technology has enormous potential for precision medicine, such as has recently been demonstrated in the field of cystic fibrosis. However, storage and use of organoids has been associated with ethical challenges ...
Responsible Research with Human Tissues: The Need for Reciprocity Toward Both Collectives and Individuals

Lensink, Michael A; Jongsma, Karin R; Boers, Sarah N; van Delden, Johannes J M; Bredenoord, Annelien L (Routledge, 2021-04-03)
Delaying the final cut: A close encounter of checkpoint kinases at the midbody

Hadders, Michael A; Lens, Susanne M A (Rockefeller University Press, 2021-02-01)

How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show ...
Global approaches to cardiogenetic evaluation after sudden cardiac death in the young: A survey among healthcare professionals

van den Heuvel, Lieke M; Do, Judy; Yeates, Laura; MacLeod, Heather; James, Cynthia A; Duflou, Johan; Skinner, Jonathan R; Semsarian, Christopher; van Tintelen, J Peter; Ingles, Jodie (Elsevier, 2021-10)

Background: Thorough investigation of sudden cardiac death (SCD) in those aged 1–40 years commonly reveals a heritable cause, yet access to postmortem genetic testing is variable. Objective: The purpose of this study was ...
Relative Efficacy of Sacubitril-Valsartan, Vericiguat, and SGLT2 Inhibitors in Heart Failure with Reduced Ejection Fraction: a Systematic Review and Network Meta-Analysis

Aimo, Alberto; Pateras, Konstantinos; Stamatelopoulos, Kimon; Bayes-Genis, Antoni; Lombardi, Carlo Mario; Passino, Claudio; Emdin, Michele; Georgiopoulos, Georgios (Kluwer Academic Publishers, 2021-10)

BACKGROUND: Sacubitril/valsartan, vericiguat, and the sodium-glucose co-transporter-2 inhibitors (SGLT2i) dapagliflozin and empagliflozin proved effective in phase 3 trials on heart failure with reduced ejection fraction ...
Proprotein Convertase Subtilisin-Kexin Type 9 inhibitors and stroke prevention: A meta-analysis

Sagris, Dimitrios; Ntaios, George; Georgiopoulos, Georgios; Pateras, Konstantinos; Milionis, Haralampos (Elsevier, 2021-03)
Combined assessment of early and late-phase outcomes in orphan drug development

Pateras, Konstantinos; Nikolakopoulos, Stavros; Roes, Kit C B (John Wiley & Sons Inc., 2021-05-30)

In drug development programs, proof-of-concept Phase II clinical trials typically have a biomarker as a primary outcome, or an outcome that can be observed with relatively short follow-up. Subsequently, the Phase III ...
CDSS-Assisted Pharmacy Intervention Reduces Feeding Tube-Related Medication Errors in Hospitalized Patients: A Focus on Medication Suitable for Feeding-Tube Administration: A Focus on Medication Suitable for Feeding-Tube Administration

Wasylewicz, Arthur T M; van Grinsven, Renske J B; Bikker, Jessica M W; Korsten, Hendrikus H M; Egberts, Toine C G; Kerskes, Catharina H M; Grouls, Rene J E (John Wiley & Sons Inc., 2021-03)

BACKGROUND: Administering medication through an enteral feeding tube (FT) is a frequent cause of errors resulting in increased morbidity and cost. Studies on interventions to prevent these errors in hospitalized patients, ...
Nature and frequency of prescription modifications in community pharmacies: A nationwide study in the Netherlands

van Loon, W E Ellen; Borgsteede, S D Sander; Baas, G W Gert; Kruijtbosch, M Martine; Buurma, H Henk; De Smet, P A G M Peter; Egberts, A C G Toine; Bouvy, M Marcel; Floor-Schreudering, A Annemieke (Wiley-Blackwell, 2021-03)

AIMS: To investigate the nature and frequency of prescription modifications in Dutch community pharmacies. METHODS: In this cross-sectional study, Dutch community pharmacists documented prescription modifications in their ...
Monitoring of Adverse Drug Reaction-Related Parameters in Children and Adolescents Treated With Antipsychotic Drugs in Psychiatric Outpatient Clinics

Minjon, Lenneke; Brozina, Ivona; Egberts, Toine C G; Heerdink, Eibert R; van den Ban, Els (Frontiers Research Foundation, 2021-02-25)

Aim: To assess the frequency of monitoring of adverse drug reaction (ADR) related parameters in children and adolescents treated with antipsychotic drugs in psychiatric outpatient clinics and the considerations when ...
Type and Extent of Information on (Potentially Critical) Quality Attributes Described in European Public Assessment Reports for Adalimumab Biosimilars

Alsamil, Ali M; Giezen, Thijs J; Egberts, Toine C; Leufkens, Hubert G; Gardarsdottir, Helga (Multidisciplinary Digital Publishing Institute, 2021-03)

Regulatory approval of biosimilars predominantly relies on biosimilarity assessments of quality attributes (QAs), particularly the potentially critical QAs (pCQAs) that may affect the clinical profile. However, a limited ...

Now showing items 16541-16560 of 40728