Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis 
    van der Stoel, Miesje; Schimmel, Lilian; Nawaz, Kalim; van Stalborch, Anne-Marieke; de Haan, Annett; Klaus-Bergmann, Alexandra; Valent, Erik T; Koenis, Duco S; van Nieuw Amerongen, Geerten P; de Vries, Carlie J; de Waard, Vivian; Gloerich, Martijn; van Buul, Jaap D; Huveneers, Stephan (Company of Biologists Ltd, 2020-02-12)
    Endothelial YAP/TAZ (YAP is also known as YAP1, and TAZ as WWTR1) signaling is crucial for sprouting angiogenesis and vascular homeostasis. However, the underlying molecular mechanisms that explain how YAP/TAZ control the ...
  • Force transduction by cadherin adhesions in morphogenesis 
    Pannekoek, Willem-Jan; de Rooij, Johan; Gloerich, Martijn (F1000 Research Ltd., 2019)
    Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons ...
  • Identification of subgroups of patients with oesophageal cancer based on exercise intensity during prehabilitation 
    Reijneveld, Elja A E; Griekspoor, Mitchel; Dronkers, Jaap J; Kerst, Ad; Ruurda, Jelle P; Veenhof, Cindy (Informa Healthcare, 2024-12)
    PURPOSE: To identify subgroups of patients with oesophageal cancer based on exercise intensity during prehabilitation, and to investigate whether training outcomes varied between subgroups. MATERIALS AND METHODS: Data from ...
  • Increased TGF-β and BMP levels and improved chondrocyte-specific marker expression in vitro under cartilage-specific physiological osmolarity 
    Timur, Ufuk Tan; Caron, Marjolein; van den Akker, Guus; van der Windt, Anna; Visser, Jenny; van Rhijn, Lodewijk; Weinans, Harrie; Welting, Tim; Emans, Pieter; Jahr, Holger (Multidisciplinary Digital Publishing Institute (MDPI), 2019-02-02)
    During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing ...
  • Additively manufactured functionally graded biodegradable porous iron 
    Li, Y.; Jahr, H.; Pavanram, P.; Bobbert, F. S.L.; Puggi, U.; Zhang, X. Y.; Pouran, B.; Leeflang, M. A.; Weinans, H.; Zhou, J.; Zadpoor, A. A. (Elsevier, 2019-09-15)
    Additively manufactured (AM) functionally graded porous metallic biomaterials offer unique opportunities to satisfy the contradictory design requirements of an ideal bone substitute. However, no functionally graded porous ...
  • Mechanical performance of auxetic meta-biomaterials 
    Kolken, H. M.A.; Lietaert, K.; van der Sloten, T.; Pouran, B.; Meynen, A.; Van Loock, G.; Weinans, H.; Scheys, L.; Zadpoor, A. A. (Elsevier, 2020-04)
    The innovative design of orthopedic implants could play an important role in the development of life-lasting implants, by improving both primary and secondary implant fixations. The concept of meta-biomaterials aims to ...
  • Dual contrast in computed tomography allows earlier characterization of articular cartilage over single contrast 
    Bhattarai, Abhisek; Pouran, Behdad; Mäkelä, Janne T.A.; Shaikh, Rubina; Honkanen, Miitu K.M.; Prakash, Mithilesh; Kröger, Heikki; Grinstaff, Mark W.; Weinans, Harrie; Jurvelin, Jukka S.; Töyräs, Juha (John Wiley & Sons Inc., 2020-10-01)
    Cationic computed tomography contrast agents are more sensitive for detecting cartilage degeneration than anionic or non-ionic agents. However, osteoarthritis-related loss of proteoglycans and increase in water content ...
  • Functionality-packed additively manufactured porous titanium implants 
    van Hengel, I. A.J.; Gelderman, F. S.A.; Athanasiadis, S.; Minneboo, M.; Weinans, H.; Fluit, A. C.; van der Eerden, B. C.J.; Fratila-Apachitei, L. E.; Apachitei, I.; Zadpoor, A. A. (Elsevier, 2020-06)
    The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess ...
  • Biodegradation-affected fatigue behavior of additively manufactured porous magnesium 
    Li, Y.; Jahr, H.; Zhang, X. Y.; Leeflang, M. A.; Li, W.; Pouran, B.; Tichelaar, F. D.; Weinans, H.; Zhou, J.; Zadpoor, A. A. (Elsevier, 2019-08)
    Additively manufactured (AM) biodegradable metals with topologically ordered porous structures hold unprecedented promise as potential bone substitutes. The first reports on this type of biomaterials have just recently ...
  • Corrigendum to “Additively manufactured functionally graded biodegradable porous iron” (Acta Biomaterialia (2019) 96 (646–661), (S1742706119304933), (10.1016/j.actbio.2019.07.013)) 
    Li, Y.; Jahr, H.; Pavanram, P.; Bobbert, F. S.L.; Paggi, U.; Zhang, X. Y.; Pouran, B.; Leeflang, M. A.; Weinans, H.; Zhou, J.; Zadpoor, A. A. (Elsevier, 2020-01-01)
    The authors regret to state that a mistake was made in the spelling of the authors’ name. The fifth author's name should be U. Paggi instead of U. Puggi. The authors apologise for any inconvenience caused.
  • Evidence for neuroinflammation after myocardial infarction in a mouse model 
    Gouweleeuw, Leonie; Pol, Christine; Simonides, Warner S.; De Kleijn, Dominique P.V.; Schoemaker, Regien G. (Wolters Kluwer Medknow Publications, 2017-10-01)
    Background: The cardiovascular system and central nervous system are known to influence each other. Accordingly, neurological changes may occur after myocardial infarction (MI), which may be mediated by neuroinflammation. ...
  • Corrigendum: Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes (JCI insight (2016) 1 7 PII: 126617) 
    Yang, Huan; Wang, Haichao; Levine, Yaakov A.; Gunasekaran, Manoj K.; Wang, Yongjun; Addorisio, Meghan; Zhu, Shu; Li, Wei; Li, Jianhua; de Kleijn, Dominique Pv; Olofsson, Peder S.; Warren, H. Shaw; He, Mingzhu; Al-Abed, Yousef; Roth, Jesse; Antoine, Daniel J.; Chavan, Sangeeta S.; Andersson, Ulf; Tracey, Kevin J. (American Society for Clinical Investigation, 2018-12-20)
  • In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors 
    Yap, Lynn; Wang, Jiong Wei; Moreno-Moral, Aida; Chong, Li Yen; Sun, Yi; Harmston, Nathan; Wang, Xiaoyuan; Chong, Suet Yen; Öhman, Miina K.; Wei, Heming; Bunte, Ralph; Gosh, Sujoy; Cook, Stuart; Hovatta, Outi; de Kleijn, Dominique P.V.; Petretto, Enrico; Tryggvason, Karl (Cell Press, 2019-03-19)
    Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for ...
  • The Impact of Diabetes and Time on the Atherosclerotic Plaque and Cardiovascular Outcome in Patients Undergoing Iliofemoral Endarterectomy 
    van Koeverden, Ian D.; Scholtes, Vincent P.W.; den Ruijter, Hester M.; Hazenberg, Stijn C.E.; de Kleijn, Dominique P.V.; de Borst, Gert J. (W.B. Saunders Ltd, 2019-06)
    Objective: The incidence of diabetes is rapidly increasing and diabetes is associated with an increased risk of peripheral artery disease. Recent studies have shown a time dependent decline in vulnerable plaque features ...
  • Innate immunity as a target for acute cardioprotection 
    Zuurbier, Coert J.; Abbate, Antonio; Cabrera-Fuentes, Hector A.; Cohen, Michael V.; Collino, Massimo; De Kleijn, Dominique P.V.; Downey, James M.; Pagliaro, Pasquale; Preissner, Klaus T.; Takahashi, Masafumi; Davidson, Sean M. (Oxford University Press, 2019-06-01)
    Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves rapid reperfusion. However, a highly ...
  • Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction 
    De Kleijn, Dominique P.V.; Chong, Suet Yen; Wang, Xiaoyuan; Yatim, Siti Maryam J.M.; Fairhurst, Anna Marie; Vernooij, Flora; Zharkova, Olga; Chan, Mark Y.; Foo, Roger S.Y.; Timmers, Leo; Lam, Carolyn S.P.; Wang, Jiong Wei (Oxford University Press, 2019-10-01)
    Aims: The Toll-like receptor 7 (TLR7) is an intracellular innate immune receptor activated by nucleic acids shed from dying cells leading to activation of the innate immune system. Since innate immune system activation is ...
  • A porcine model of heart failure with preserved ejection fraction: magnetic resonance imaging and metabolic energetics 
    Charles, Christopher J.; Lee, Philip; Li, Renee R.; Yeung, Teresa; Ibraham Mazlan, Stephane M.; Tay, Zhi Wei; Abdurrachim, Desiree; Teo, Xing Qi; Wang, Wei Hsin; de Kleijn, Dominique P.V.; Cozzone, Patrick J.; Lam, Carolyn S.P.; Richards, A. Mark (John Wiley & Sons Inc., 2020-02-01)
    Aims: A significant proportion of heart failure (HF) patients have HF preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF remains a critical unmet need. A key obstacle to therapeutic innovation ...
  • Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation 
    Schnitzler, Johan G.; Hoogeveen, Renate M.; Ali, Lubna; Prange, Koen H.M.; Waissi, Farahnaz; van Weeghel, Michel; Bachmann, Julian C.; Versloot, Miranda; Borrelli, Matthew J.; Yeang, Calvin; De Kleijn, Dominique P.V.; Houtkooper, Riekelt H.; Koschinsky, Marlys L.; De Winther, Menno P.J.; Groen, Albert K.; Witztum, Joseph L.; Tsimikas, Sotirios; Stroes, Erik S.G.; Kroon, Jeffrey (Lippincott Williams & Wilkins, 2020-05-08)
    RATIONALE: Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission tomography/computed tomography, indicative of a proinflammatory ...
  • Erratum: In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors (Cell Reports (2019) 26(12) (3231–3245.e9), (S2211124719302694), (10.1016/j.celrep.2019.02.083)) 
    Yap, Lynn; Wang, Jiong Wei; Moreno-Moral, Aida; Chong, Li Yen; Sun, Yi; Harmston, Nathan; Wang, Xiaoyuan; Chong, Suet Yen; Vanezis, Konstantinos; Öhman, Miina K.; Wei, Heming; Bunte, Ralph; Gosh, Sujoy; Cook, Stuart; Hovatta, Outi; de Kleijn, Dominique P.V.; Petretto, Enrico; Tryggvason, Karl (Cell Press, 2020-05-26)
    (Cell Reports 26, 3231–3245.e1–e9; March 19, 2019) In the originally published version of this article, Konstantinos Vanezis was mistakenly omitted from the author list. This has now been corrected. The authors regret the error.
  • International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19 
    Börger, Verena; Weiss, Daniel J.; Anderson, Johnathon D.; Borràs, Francesc E.; Bussolati, Benedetta; Carter, David R.F.; Dominici, Massimo; Falcón-Pérez, Juan M.; Gimona, Mario; Hill, Andrew F.; Hoffman, Andrew M.; de Kleijn, Dominique; Levine, Bruce L.; Lim, Rebecca; Lötvall, Jan; Mitsialis, S. Alex; Monguió-Tortajada, Marta; Muraca, Maurizio; Nieuwland, Rienk; Nowocin, Anna; O'Driscoll, Lorraine; Ortiz, Luis A.; Phinney, Donald G.; Reischl, Ilona; Rohde, Eva; Sanzenbacher, Ralf; Théry, Clotilde; Toh, Wei Seong; Witwer, Kenneth W.; Lim, Sai Kiang; Giebel, Bernd (Informa Healthcare, 2020-09)
    STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from ...