In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

Yap, Lynn; Wang, Jiong Wei; Moreno-Moral, Aida; Chong, Li Yen; Sun, Yi; Harmston, Nathan; Wang, Xiaoyuan; Chong, Suet Yen; Öhman, Miina K.; Wei, Heming; Bunte, Ralph; Gosh, Sujoy; Cook, Stuart; Hovatta, Outi; de Kleijn, Dominique P.V.; Petretto, Enrico; Tryggvason, Karl

doi:https://doi.org/10.1016/j.celrep.2019.02.083

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

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In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

Yap, Lynn; Wang, Jiong Wei; Moreno-Moral, Aida; Chong, Li Yen; Sun, Yi; Harmston, Nathan; Wang, Xiaoyuan; Chong, Suet Yen; Öhman, Miina K.; Wei, Heming; Bunte, Ralph; Gosh, Sujoy; Cook, Stuart; Hovatta, Outi; de Kleijn, Dominique P.V.; Petretto, Enrico; Tryggvason, Karl

(2019) Cell Reports, volume 26, issue 12, pp. 3231 - 3245.e9

(Article)

Abstract

Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.

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Keywords: cardiovascular progenitors, hESC-based cardiac muscle regeneration, laminin, regenerative cardiology, General Biochemistry,Genetics and Molecular Biology

DOI: https://doi.org/10.1016/j.celrep.2019.02.083

ISSN: 2211-1247

Publisher: Cell Press

(Peer reviewed)