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Now showing items 3261-3280 of 40729

Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein

Fiolet, Aernoud T.L.; Silvis, Max J.M.; Opstal, Tjerk S.J.; Bax, Willem A.; van der Horst, Frans A.L.; Mosterd, Arend; de Kleijn, Dominique; Cornel, Jan H. (Public Library of Science, 2020-08)

Aims Inflammation plays a pivotal role in atherothrombosis. Colchicine is an anti-inflammatory drug that may attenuate this process. Cardiovascular protective effects of anti-inflammatory drugs, however, seem to be limited ...
Colchicine Attenuates Inflammation Beyond the Inflammasome in Chronic Coronary Artery Disease A LoDoCo2 Proteomic Substudy

Opstal, Tjerk S.J.; Hoogeveen, Renate M.; Fiolet, Aernoud T.L.; Silvis, Max J.M.; The, Salem H.K.; Bax, Willem A.; de Kleijn, Dominique P.V.; Mosterd, Arend; Stroes, Erik S.G.; Cornel, Jan H. (Lippincott Williams & Wilkins, 2020-11-17)
Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability

Poels, Kikkie; Schnitzler, Johan G.; Waissi, Farahnaz; Levels, Johannes H.M.; Stroes, Erik S.G.; Daemen, Mat J.A.P.; Lutgens, Esther; Pennekamp, Anne Marije; De Kleijn, Dominique P.V.; Seijkens, Tom T.P.; Kroon, Jeffrey (Frontiers Media S. A., 2020-11-12)

Aims: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB)3-mediated glycolysis is pivotal in driving macrophage- and endothelial cell activation and thereby inflammation. Once activated, these cells play a crucial ...
Qualitative study on shared decision making in cystitis management in general practice

van Horrik, Tessa Mzxk; Colliers, Annelies; Blanker, Marco H; de Bont, Eefje Gpm; van Driel, Antoinette A; Laan, Bart J; Geerlings, Suzanne E; Venekamp, Roderick P; Anthierens, Sibyl; Platteel, Tamara N (Royal College of General Practitioners, 2024-10)

Background: Cystitis is commonly treated with antibiotics, although non-antibiotic options could be considered for healthy non-pregnant women. Shared decision making (SDM) can be used in cystitis management to discuss the ...
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

Jelluma, Nannette; Yang, Xiaodong; Stokoe, David; Evan, Gerard I.; Dansen, Tobias B.; Haas-Kogan, Daphne A. (American Association for Cancer Research Inc., 2006-05)

Tumor cells rely preferentially on anaerobic glycolysis rather than on respiration for ATP generation, a phenomenon known as the Warburg effect. We explored the effects of glucose withdrawal on glioblastoma multiforme-derived ...
Forkhead Box O transcription factors: Key players in redox signaling

Dansen, Tobias B. (Mary Ann Liebert Inc., 2011-02-15)

The Forkhead Box O (FOXO) transcription factors are famous for their role in longevity: both Caenorhabditis elegans and Drosophila melanogaster can extend their median and maximum lifespan in a FOXO-dependent manner, and ...
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A

Göbl, Christoph; Morris, Vanessa K.; van Dam, Loes; Visscher, Marieke; Polderman, Paulien E.; Hartlmüller, Christoph; de Ruiter, Hesther; Hora, Manuel; Liesinger, Laura; Birner-Gruenberger, Ruth; Vos, Harmjan R.; Reif, Bernd; Madl, Tobias; Dansen, Tobias B. (Elsevier, 2020-01)

The tumor suppressor p16INK4A induces cell cycle arrest and senescence in response to oncogenic transformation and is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of oxidative ...
Cross-talk between redox signalling and protein aggregation

van Dam, Loes; Dansen, Tobias B. (Portland Press Ltd., 2020-04)

It is well established that both an increase in reactive oxygen species (ROS: i.e. O2•−, H2O2 and OH•), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease. ...
Redox signaling modulates Rho activity and tissue contractility in the Caenorhabditis elegans spermatheca

Kelley, Charlotte A.; de Henau, Sasha; Bell, Liam; Dansen, Tobias B.; Crama, Erin J. (American Society for Cell Biology, 2020-07-01)

Actomyosin-based contractility in smooth muscle and nonmuscle cells is regulated by signaling through the small GTPase Rho and by calcium-activated pathways. We use the myoepithelial cells of the Caenorhabditis elegans ...
Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?

Shi, Tao; Dansen, Tobias B. (Mary Ann Liebert Inc., 2020-10-20)

Significance: The p53 tumor suppressor has been dubbed the "guardian of genome"because of its various roles in the response to DNA damage such as DNA damage repair, cell cycle arrest, senescence, and apoptosis, all of which ...
Rheumatoid arthritis patients' perspective on the use of prediction models in clinical decision-making

Messelink, Marianne A; Fadaei, Sina; Verhoef, Lise M; Welsing, Paco; Nijhof, Nienke C; Westland, Heleen (Oxford University Press, 2025-03)

Objectives: A rapidly expanding number of prediction models is being developed, aiming to improve RA diagnosis and treatment. However, few are actually implemented in clinical practice. This study explores factors influencing ...
Intraarticular soluble interleukin-17 receptor levels are increased in patients with rheumatoid arthritis and correlate with local mediators of inflammation: Comment on the article by Pickens et al

Moret, Frederique M.; Badot, Valerie; Lauwerys, Bernard R.; Van Roon, Joel A.G. (John Wiley & Sons Inc., 2012-02)
Activating and inhibitory Fcγ receptors in rheumatoid arthritis: From treatment to targeted therapies

Van Roon, Joel A.G. (BioMed Central Ltd., 2007-08-20)

Fcγ receptors (FcγRs) bind the constant Fc region of IgG molecules. IgG/antigen-containing immune complexes elicit a variety of effector functions in cells that express activating FcγRs. Because activating FcγRs are present ...
Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome

Maria, Naomi I.; van Helden-Meeuwsen, Cornelia G.; Brkic, Zana; Paulissen, Sandra M.J.; Steenwijk, Eline C.; Dalm, Virgil A.; van Daele, Paul L.; Martin van Hagen, P.; Kroese, Frans G.M.; van Roon, Joel A.G.; Harkin, Andrew; Dik, Willem A.; Drexhage, Hemmo A.; Lubberts, Erik; Versnel, Marjan A. (John Wiley & Sons Inc., 2016-07-01)

Objective: Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme that converts tryptophan to kynurenine, is driven in part by type I and type II interferons (IFNs). Naive T cells are polarized into FoxP3+ Treg cells ...
Editorial: Closing in on the Role of Thymic Stromal Lymphopoietin Inhibition as a Therapeutic Entry Point for Systemic Sclerosis

Affandi, Alsya J.; van Roon, Joel A.G. (John Wiley & Sons Inc., 2016-11-01)
Autoantibodies to cytosolic 5'-nucleotidase 1A in primary Sjögren's syndrome and systemic lupus erythematosus

Rietveld, Anke; van den Hoogen, Luuk L.; Bizzaro, Nicola; Blokland, Sofie L.M.; Dähnrich, Cornelia; Gottenberg, Jacques Eric; Houen, Gunnar; Johannsen, Nora; Mandl, Thomas; Meyer, Alain; Nielsen, Christoffer T.; Olsson, Peter; van Roon, Joel; Schlumberger, Wolfgang; van Engelen, Baziel G.M.; Saris, Christiaan G.J.; Pruijn, Ger J.M. (Frontiers Media S. A., 2018-06-05)

Introduction: Autoantibodies to cytosolic 5'-nucleotidase 1A (cN-1A; NT5C1A) have a high specificity when differentiating sporadic inclusion body myositis from polymyositis and dermatomyositis. In primary Sjögren's syndrome ...
Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren’s syndrome to facilitate their concerted migration

Blokland, Sofie L.M.; Kislat, Andreas; Homey, Bernhard; Smithson, Glennda M.; Kruize, Aike A.; Radstake, Timothy R.D.J.; van Roon, Joel A.G. (Wiley-Blackwell, 2020-03-01)

CCR9 + T helper (Th) cells can induce Sjögren-like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. Increased circulating ...
Relatives' Unmet Needs in the Last Year of Life of Patients With Advanced Cancer: Results of a Dutch Prospective, Longitudinal Study (eQuiPe)

Ham, Laurien; Fransen, Heidi P; de Graeff, Alexander; Hendriks, Mathijs P; de Jong, Wouter K; Kloover, Jeroen; Kuip, Evelien; Mandigers, Caroline; Sommeijer, Dirkje; van de Poll, Lonneke; Raijmakers, Natasja; van Zuylen, Lia (SAGE Publications Inc., 2025-01)

Objective(s): Unmet needs of relatives of patients with advanced cancer not only reduce their own health-related quality of life, but may also negatively affect patients' health outcomes. The aim of this study was to assess ...
Computational pan-genomics: Status, promises and challenges

The Computational Pan-Genomics Consortium (Oxford University Press, 2018-01-01)

Many disciplines, from human genetics and oncology to plant breeding, microbiology and virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes. In case of Homo sapiens, the number of sequenced ...
From squiggle to basepair: Computational approaches for improving nanopore sequencing read accuracy

Rang, Franka J.; Kloosterman, Wigard P.; de Ridder, Jeroen (BioMed Central, 2018-07-13)

Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this new way of sequencing and has used it ...

Now showing items 3261-3280 of 40729