Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Optimizing the detection of hereditary predisposition in women with epithelial ovarian cancer: nationwide implementation of the Tumor-First workflow 
    Witjes, Vera M; Hermkens, Dorien M A; Swillens, Julie E M; Smolders, Yvonne H C M; Mourits, Marian J E; Ausems, Margreet G E M; de Hullu, Joanne A; Ligtenberg, Marjolijn J L; Hoogerbrugge, Nicoline (Springer Netherlands, 2024-11)
    Genetic testing in patients with ovarian carcinoma (OC) is crucial, as around 10-15% of these women have a genetic predisposition to OC. Although guidelines have recommended universal germline testing for all patients with ...
  • Long-term Changes in Personal Recovery and Quality of Life Among Patients With Schizophrenia Spectrum Disorders and Different Durations of Illness: A Meta-analysis 
    de Winter, Lars; Jelsma, Auke; Vermeulen, Jentien M; van Weeghel, Jaap; Hasson-Ohayon, Ilanit; Mulder, Cornelis L; Boonstra, Nynke; Veling, Wim; de Haan, Lieuwe (Oxford University Press, 2024-12-20)
    Background and Hypothesis: In schizophrenia spectrum disorders (SSD) personal recovery and subjective quality of life (S-QOL) are crucial and show conceptual overlap. There is limited knowledge about how these outcomes ...
  • Intracranial arterial calcification in patients with unruptured and ruptured intracranial aneurysms 
    Kamphuis, Maarten J; van der Kamp, Laura T; Lette, Edwin; Rinkel, Gabriel J E; Vergouwen, Mervyn D I; van der Schaaf, Irene C; de Jong, Pim A; Ruigrok, Ynte M (Springer-Verlag, 2024-11)
    Objectives: Arterial calcification is thought to protect against rupture of intracranial aneurysms, but studies in a representative population of intracranial aneurysm patients have not yet been performed. The aim was to ...
  • Quantitative muscle magnetic resonance imaging in limb-girdle muscular dystrophy type R1 (LGMDR1): A prospective longitudinal cohort study 
    Forsting, Johannes; Wächter, Marian; Froeling, Martijn; Rohm, Marlena; Güttsches, Anne Katrin; De Lorenzo, Alice; Südkamp, Nicolina; Kocabas, Abdulhadi; Vorgerd, Matthias; Enax-Krumova, Elena; Rehmann, Robert; Schlaffke, Lara (John Wiley & Sons Inc., 2024-10)
    Limb-girdle muscular dystrophy (LGMD) type R1 (LGMDR1) is the most common subtype of LGMD in Europe. Prospective longitudinal data, including clinical assessments and new biomarkers such as quantitative magnetic resonance ...
  • Outcomes of patients aged ≥26 years with relapsed or refractory B-cell acute lymphoblastic leukemia in ZUMA-3 and historical trials 
    Minnema, Monique C; Yin, Xiang; Davi, Ruthanna; Keeping, Sam; Park, Julie E; Itani, Taha; Hadjivassileva, Tsveta; Castaigne, Jean-Gabriel; Damico Khalid, Rita; Zhou, Lang; Wu, James J; Shah, Bijal D (2024-10)
    Brexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 CAR T-cell therapy approved in the USA and European Union (EU) for adults with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL; aged ...
  • Large- and medium-sized arterial aneurysms in two patients with SMAD4-related juvenile polyposis syndrome 
    van Weelden, Wenneke; Bleeker, Fonnet E; van Stijn, Diana; Micha, Dimitra; Maugeri, Alessandra; Kuijpers, Taco W; Koch, Arjun D; Aalfs, Cora M; Wagner, Anja; Groenink, Maarten; van Oldenrijk, Jakob; Baars, Marieke J; Duijkers, Floor A M (John Wiley & Sons Inc., 2024-10)
    Germline SMAD4 pathogenic variants (PVs) cause juvenile polyposis syndrome (JPS), which is known for an increased risk of gastrointestinal juvenile polyps and gastrointestinal cancer. Many patients with SMAD4 PV also show ...
  • The effects of gaze-display feedback on medical students’ self-monitoring and learning in radiology 
    Kok, Ellen M.; Niehorster, Diederick C.; van der Gijp, Anouk; Rutgers, Dirk R.; Auffermann, William F.; van der Schaaf, Marieke; Kester, Liesbeth; van Gog, Tamara (Springer Netherlands, 2024-11)
    Self-monitoring is essential for effectively regulating learning, but difficult in visual diagnostic tasks such as radiograph interpretation. Eye-tracking technology can visualize viewing behavior in gaze displays, thereby ...
  • The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe 
    Selten, J P; Di Forti, M; Quattrone, D; Jones, P B; Jongsma, H E; Gayer-Anderson, C; Szöke, A; Llorca, P M; Arango, C; Bernardo, M; Sanjuan, J; Santos, J L; Arrojo, M; Tarricone, I; Berardi, D; Lasalvia, A; Tosato, S; la Cascia, C; Velthorst, E; van der Ven, E M A; de Haan, L; Rutten, B P; van Os, J; Kirkbride, J B; Morgan, C M; Murray, R M; Termorshuizen, F (Cambridge University Press, 2024-08)
    BACKGROUND: We examined whether cannabis use contributes to the increased risk of psychotic disorder for non-western minorities in Europe. METHODS: We used data from the EU-GEI study (collected at sites in Spain, Italy, ...
  • Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission 
    Stern, Shani; Zhang, Lei; Wang, Meiyan; Wright, Rebecca; Rosh, Idan; Hussein, Yara; Stern, Tchelet; Choudhary, Ashwani; Tripathi, Utkarsh; Reed, Patrick; Sadis, Hagit; Nayak, Ritu; Shemen, Aviram; Agarwal, Karishma; Cordeiro, Diogo; Peles, David; Hang, Yuqing; Mendes, Ana P.D.; Baul, Tithi D.; Roth, Julien G.; Coorapati, Shashank; Boks, Marco P.; McCombie, W. Richard; Hulshoff Pol, Hilleke; Brennand, Kristen J.; Réthelyi, János M.; Kahn, René S.; Marchetto, Maria C.; Gage, Fred H. (Springer Nature, 2024-10)
    Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, ...
  • The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis 
    Pan, Kuan-Yu; van Tuijl, Lonneke; Basten, Maartje; Rijnhart, Judith J M; de Graeff, Alexander; Dekker, Joost; Geerlings, Mirjam I; Hoogendoorn, Adriaan; Ranchor, Adelita V; Vermeulen, Roel; Portengen, Lützen; Voogd, Adri C; Abell, Jessica; Awadalla, Philip; Beekman, Aartjan T F; Bjerkeset, Ottar; Boyd, Andy; Cui, Yunsong; Frank, Philipp; Galenkamp, Henrike; Garssen, Bert; Hellingman, Sean; Hollander, Monika; Huisman, Martijn; Huss, Anke; Keats, Melanie R; Kok, Almar A L; Krokstad, Steinar; van Leeuwen, Flora E; Luik, Annemarie I; Noisel, Nolwenn; Payette, Yves; Penninx, Brenda W J H; Picavet, Susan; Rissanen, Ina; Roest, Annelieke M; Rosmalen, Judith G M; Ruiter, Rikje; Schoevers, Robert A; Soave, David; Spaan, Mandy; Steptoe, Andrew; Stronks, Karien; Sund, Erik R; Sweeney, Ellen; Teyhan, Alison; Twait, Emma L; van der Willik, Kimberly D; Lamers, Femke (Cambridge University Press, 2024-07)
    BACKGROUND: Although behavioral mechanisms in the association among depression, anxiety, and cancer are plausible, few studies have empirically studied mediation by health behaviors. We aimed to examine the mediating role ...
  • Serological profiling of pneumococcal proteins reveals unique patterns of acquisition, maintenance and waning of antibodies throughout life 
    He, Samantha W J; Voß, Franziska; Nicolaie, Mioara A; Brummelman, Jolanda; van de Garde, Martijn D B; Bijvank, Elske; Poelen, Martien; Wijmenga-Monsuur, Alienke J; Wyllie, Anne L; Trzciński, Krzysztof; Van Beek, Josine; Rots, Nynke Y; den Hartog, Gerco; Hammerschmidt, Sven; van Els, Cécile A C M (Oxford University Press, 2024-12-15)
    Streptococcus pneumoniae is a leading cause of morbidity and mortality in children and older adults. However, knowledge on the development of pneumococcal protein-specific antibody responses throughout life is limited. To ...
  • Development and content validity of the cognition in daily life scale (CDL) 
    Domensino, Anne-Fleur; Aarts, Elyan; Visser-Meily, Johanna M A; Spikman, Jacoba M; van Heugten, Caroline (Taylor and Francis Ltd., 2025)
    Cognitive impairment can negatively influence daily functioning. Current cognitive measures are essential for diagnosing cognitive impairment, but findings on these tests do not always represent the level of cognitive ...
  • The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study 
    Üçok, Alp; Noyan, Handan; Gülöksüz, Sinan; Saka, Meram Can; Alptekin, Köksal; Atbaşoğlu, Cem; Akturan, Elçin; Karadayı, Gülşah; Baran Tatar, Zeynep; Akdede, Berna; Binbay, Tolga; Altınyazar, Vesile; Ulaş, Halis; Yalınçetin, Berna; Gümüş-Akay, Güvem; Cihan, Burçin; Soygür, Haldun; Şahin Cankurtaran, Eylem; Ulusoy Kaymak, Semra; Rutten, Bart P F; van Os, Jim (Cambridge University Press, 2024-07)
    BACKGROUND: The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little ...
  • Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis 
    de Jong, Pim A; Harlianto, Netanja I; Foppen, Wouter; Renkli, Nağme Ö; Spiering, Wilko; Weinans, Harrie; PThM Mali, Willem; Mastbergen, Simon C; Jansen, Mylène P (Oxford University Press, 2025-03)
    Objectives: Ectopic bone deposition plays an important role in OA and in arterial wall disease. We aimed to investigate the prevalence and progression of arterial calcifications on whole-body CT in persons with knee OA. ...
  • Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis? Data from the IMI-APPROACH cohort 
    Jansen, M. P.; Hodgins, D.; Mastbergen, S. C.; Kloppenburg, M.; Blanco, F. J.; Haugen, I. K.; Berenbaum, F.; Eckstein, F.; Roemer, F. W.; Wirth, W. (Springer-Verlag, 2024-11)
    Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected (GaitSmart®) and ...
  • Comparison of Clinical Efficacy and Mechanical Characteristics of Two Knee Distraction Devices With Relevance for Clinical Practice 
    Struik, T.; Jansen, M. P.; Lafeber, R. G.P.; Lafeber, F. P.J.G.; Mastbergen, S. C. (SAGE Publications Inc., 2024-12)
    Objective: Distraction treatment for severe osteoarthritis below the age of 65 successfully postpones arthroplasty. Most patients have been treated with a general external fixator or a device specifically intended for knee ...
  • Reply to Buzón-Martín and Troya 
    van Welzen, Berend J; Burger, David; Wensing, Annemarie M J (Oxford University Press, 2025-02-05)
  • Development and validation of a lifetime prediction model for incident type 2 diabetes in patients with established cardiovascular disease: the CVD2DM model 
    Helmink, Marga A G; Peters, Sanne A E; Westerink, Jan; Harris, Katie; Tillmann, Taavi; Woodward, Mark; van Sloten, Thomas T; van der Meer, Manon G; Teraa, Martin; Dorresteijn, Jannick A N; Ruigrok, Ynte M; Visseren, Frank L J; Hageman, Steven H J; UCC-SMART Study Group (Oxford University Press, 2024-10-01)
    AIMS: Identifying patients with established cardiovascular disease (CVD) who are at high risk of type 2 diabetes (T2D) may allow for early interventions, reducing the development of T2D and associated morbidity. The aim ...
  • Direct spatial control of Epac1 by cyclic AMP 
    Ponsioen, Bas; Gloerich, Martijn; Ritsma, Laila; Rehmann, Holger; Bos, Johannes L; Jalink, Kees (Taylor and Francis Ltd., 2009-05)
    Epac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of its ...
  • Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells 
    Ortega, Fabian E; Rengarajan, Michelle; Chavez, Natalie; Radhakrishnan, Prathima; Gloerich, Martijn; Bianchini, Julie; Siemers, Kathleen; Luckett, William S; Lauer, Peter; Nelson, W James; Theriot, Julie A (American Society for Cell Biology, 2017-11-01)
    The intestinal epithelium is the first physiological barrier breached by the Gram-positive facultative pathogen Listeria monocytogenes during an in vivo infection. Listeria monocytogenes binds to the epithelial host cell ...