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UMC Repository: Recent submissions

  • Aanhoudende lichamelijke klachten bij kinderen 
    Broekhuijsen-van Henten, Dorien; Luitse, Gert; van de Putte, Elise; Berger, Marjolein (Bohn Stafleu van Loghum, 2023-09-25)
  • Unravelling the clinical heterogeneity of undefined recurrent fever over time in the European registries on Autoinflammation 
    Vyzhga, Y.; Wittkowski, H.; Hentgen, V.; Georgin-Lavialle, S.; Theodoropoulou, A.; Fuehner, S.; Jesenak, M.; Frenkel, J.; Papadopoulou-Alataki, E.; Anton, Jordi; Olivieri, A. Nunzia; Brunner, J.; Sanchez, J.; Koné-Paut, I.; Fingerhutova, S.; Pillet, P.; Meinzer, U.; Khubchandani, R.; Jansson, A.; Haas, J. P.; Berendes, R.; Kallinich, T.; Horneff, G.; Lilienthal, E.; Papa, R.; Foell, D.; Lainka, E.; Caorsi, R.; Gattorno, M.; Hofer, M. (BioMed Central Ltd., 2024-05-17)
    Background: Systemic autoinflammatory disorders (SAIDs) represent a growing spectrum of diseases characterized by dysregulation of the innate immune system. The most common pediatric autoinflammatory fever syndrome, Periodic ...
  • Monitoring of Adverse Events and Safety in Autoinflammatory Diseases: Real-Life Data from the Eurofever Registry 
    Vyzhga, Yulia; Frenkel, Joost; Insalaco, Antonella; Anton, Jordi; Koné-Paut, Isabelle; Legger, G. Elizabeth; Fabio, Giovanna; Cattalini, Marco; Kamphuis, Sylvia; Hachulla, Eric; Krause, Karoline; Ekinci, Zelal; Sanchez-Manubens, Judith; Van den Berg, J. Merlijn; Mora, Cristina Herrera; Brinkman, Danielle; Labrador, Eztizen; Potjewijd, Judith; Carlini, Luca; Bustaffa, Marta; Caorsi, Roberta; Ruperto, Nicolino; Gattorno, Marco (Springer New York, 2024-05-17)
    Objectives: The study is aimed to evaluate the impact of safety events in the Eurofever registry for Autoinflammatory diseases. Methods: This was a retrospective and longitudinal observational multicentre study. Data were ...
  • Seasonal Azithromycin Use in Paediatric Protracted Bacterial Bronchitis Does Not Promote Antimicrobial Resistance but Does Modulate the Nasopharyngeal Microbiome 
    Hardman, Simon J.; Shackley, Fiona M.; Ugonna, Kelechi; Darton, Thomas C.; Rigby, Alan S.; Bogaert, Debby; Binkowska, Justyna M.; Condliffe, Alison M. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-11-07)
    Protracted bacterial bronchitis (PBB) causes chronic wet cough for which seasonal azithromycin is increasingly used to reduce exacerbations. We investigated the impact of seasonal azithromycin on antimicrobial resistance ...
  • Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms 
    the ISARIC Clinical Characterisation Group (Elsevier, 2024-05-30)
    Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes ...
  • A multi-country analysis of COVID-19 hospitalizations by vaccination status 
    ISARIC Clinical Characterisation Group (Cell Press, 2023-11-10)
    Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients ...
  • Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations 
    Delpiano, Livia; Rodenburg, Lisa W.; Burke, Matthew; Nelson, Glyn; Amatngalim, Gimano D.; Beekman, Jeffrey M.; Gray, Michael A. (National Academy of Sciences, 2023-11-15)
    In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises innate defence mechanisms, predisposing to pulmonary failure. ...
  • Nasopharyngeal microbiota in children is associated with severe asthma exacerbations 
    van Beveren, Gina J.; de Steenhuijsen Piters, Wouter A.A.; Boeschoten, Shelley A.; Louman, Sam; Chu, Mei Ling; Arp, Kayleigh; Fraaij, Pieter L.; de Hoog, Matthijs; Buysse, Corinne; van Houten, Marlies A.; Sanders, Elisabeth A.M.; Merkus, Peter J.F.M.; Boehmer, Annemie L.; Bogaert, Debby (Mosby Inc., 2024-06)
    Background: The respiratory microbiome has been associated with the etiology and disease course of asthma. Objective: We sought to assess the nasopharyngeal microbiota in children with a severe asthma exacerbation and their ...
  • Clinical presentation and outcome of invasive mould disease in paediatric patients with acute lymphoblastic leukaemia 
    Bury, Didi; Parmentier, Corline E.J.; Tissing, Wim J.E.; Pieters, Rob; Bont, Louis J.; Brüggemann, Roger J.; Wolfs, Tom F.W. (Elsevier, 2024-06)
    Background: Childhood acute lymphoblastic leukaemia (ALL) cure rates have improved, but invasive mould disease (IMD) remains a life-threatening complication. Here, we evaluate the epidemiology, clinical presentation, ...
  • Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses 
    ISARIC4C Investigators (Nature Publishing Group, 2023-12-22)
    To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute ...
  • Selective decontamination of the digestive tract in critically ill children: Fighting fire with fire or burning down the house? 
    Bogaert, Debby; Van Schaik, Willem (BMJ Publishing Group, 2024-06)
  • Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior 
    Jansen, Suze A.; Cutilli, Alessandro; de Koning, Coco; van Hoesel, Marliek; Frederiks, Cynthia L.; Saiz Sierra, Leire; Nierkens, Stefan; Mokry, Michal; Nieuwenhuis, Edward E.S.; Hanash, Alan M.; Mocholi, Enric; Coffer, Paul J.; Lindemans, Caroline A. (Elsevier, 2024-06-21)
    The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct ...
  • Cortical electrical stimulation in epilepsy patients 
    van Blooijs, Dorien (Utrecht University, 2024-07-04)
    Patients with epilepsy arising from the primary sensorimotor cortex have disabling seizures that are hard to treat with the standard treatment options e.g. anti-seizure medication and epilepsy surgery. The region where ...
  • Neuroblastoma With Intraspinal Extension: Health Problems in Long-Term Survivors 
    Kraal, Kathelijne; Blom, Thomas; Tytgat, Lieve; van Santen, Hanneke; van Noesel, Max; Smets, Anne; Bramer, Jos; Caron, Huib; Kremer, Leontien; van der Pal, Heleen (Wiley-Liss Inc., 2016-06-01)
    Aim: To evaluate the prevalence of health problems in 5-year survivors treated for neuroblastoma (NBL) with intraspinal extension. Patients and Methods: Retrospective, single center cohort study (using data from Childhood ...
  • Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing 
    Zheng, Shuxuan; Rümke, Lidewij L.W.; Tello Rubio, Bruno; Rogers, Malbert R.C.; Van Sluis, Geerte L.; Kuball, Jürgen H.E.; Riezebos-Brilman, Annelies; Lebbink, Robert Jan; Verduyn Lunel, Frans M. (Oxford University Press, 2024-05-01)
    We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple ...
  • Interobserver variation in tumor delineation of liver metastases using Magnetic Resonance Imaging 
    Peltenburg, Julia E.; Hosni, Ali; Bahij, Rana; Boeke, Simon; Braam, Pètra M.; Hall, William A.; Intven, Martijn P.W.; Nicosia, Luca; Sonke, Jan Jakob; Witte, Marnix; Nowee, Marlies E.; Janssen, Tomas (Elsevier, 2024-04)
    Background and purpose: Magnetic Resonance Imaging (MRI) guided stereotactic body radiotherapy (SBRT) of liver metastases is an upcoming high-precision non-invasive treatment. Interobserver variation (IOV) in tumor ...
  • Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies 
    Asarkar, Ameya A.; Chang, Brent A.; de Bree, Remco; Kowalski, Luiz P.; Guntinas-Lichius, Orlando; Bradley, Patrick J.; de Graaf, Pim; Strojan, Primož; Rao, Karthik N.; Mäkitie, Antti A.; López, Fernando; Rinaldo, Alessandra; Palme, Carsten; Genden, Eric M.; Sanabria, Alvaro; Rodrigo, Juan P.; Ferlito, Alfio (Springer, 2024-06)
    Introduction: Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy. Methods: A review of literature using PubMED was performed for studies ...
  • Treatment planning for MR-guided SBRT of pancreatic tumors on a 1.5 T MR-Linac: A global consensus protocol 
    Grimbergen, Guus; Eijkelenkamp, Hidde; Snoeren, Louk M.W.; Bahij, Rana; Bernchou, Uffe; van der Bijl, Erik; Heerkens, Hanne D.; Binda, Shawn; Ng, Sylvia S.W.; Bouchart, Christelle; Paquier, Zelda; Brown, Kerryn; Khor, Richard; Chuter, Robert; Freear, Linnéa; Dunlop, Alex; Mitchell, Robert Adam; Erickson, Beth A.; Hall, William A.; Godoy Scripes, Paola; Tyagi, Neelam; de Leon, Jeremiah; Tran, Charles; Oh, Seungjong; Renz, Paul; Shessel, Andrea; Taylor, Edward; Intven, Martijn P.W.; Meijer, Gert J. (Elsevier Ireland Ltd, 2024-07)
    Background and purpose: Treatment planning for MR-guided stereotactic body radiotherapy (SBRT) for pancreatic tumors can be challenging, leading to a wide variation of protocols and practices. This study aimed to harmonize ...
  • The coax monopole antenna: A flexible end-fed antenna for ultrahigh field transmit/receive arrays 
    Budé, Lyanne M.I.; Steensma, Bart R.; Zivkovic, Irena; Raaijmakers, Alexander J.E. (John Wiley & Sons Inc., 2024-07)
    Purpose: The coax monopole antenna is presented for body imaging at 7 T. The antenna is fed at one end, eliminating the possibility of cable-coil coupling and simplifying cable routing. Additionally, its flexibility improves ...
  • Unfair knowledge practices in global health: a realist synthesis 
    Abimbola, Seye; van de Kamp, Judith; Lariat, Joni; Rathod, Lekha; Klipstein-Grobusch, Kerstin; van der Graaf, Rieke; Bhakuni, Himani (Oxford University Press, 2024-06-03)
    Unfair knowledge practices easily beset our efforts to achieve health equity within and between countries. Enacted by people from a distance and from a position of power ('the centre') on behalf of and alongside people ...