Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

Zheng, Shuxuan; Rümke, Lidewij L.W.; Tello Rubio, Bruno; Rogers, Malbert R.C.; Van Sluis, Geerte L.; Kuball, Jürgen H.E.; Riezebos-Brilman, Annelies; Lebbink, Robert Jan; Verduyn Lunel, Frans M.

doi:https://doi.org/10.1093/ofid/ofae250

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

DSpace/Manakin Repository

Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

Zheng, Shuxuan; Rümke, Lidewij L.W.; Tello Rubio, Bruno; Rogers, Malbert R.C.; Van Sluis, Geerte L.; Kuball, Jürgen H.E.; Riezebos-Brilman, Annelies; Lebbink, Robert Jan; Verduyn Lunel, Frans M.

(2024) Open Forum Infectious Diseases, volume 11, issue 5

(Article)

Abstract

We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

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Keywords: aciclovir, foscarnet, HSV-1, multidrug resistance, stem cell transplantation, Oncology, Infectious Diseases

DOI: https://doi.org/10.1093/ofid/ofae250

ISSN: 2328-8957

Publisher: Oxford University Press

(Peer reviewed)