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UMC Repository: Recent submissions

  • Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration 
    van Dommelen, Julia E M; Grootjans, Heleen; Uijtendaal, Esther V; Ruigrok, Dieuwertje; Luijk, Bart; van Luin, Matthijs; Bult, Wouter; de Lange, Dylan W; Kusadasi, Nuray; Droogh, Joep M; Egberts, Toine C G; Verschuuren, Erik A M; Sikma, Maaike A (Adis, 2024-05)
    Background and Objective: High variability in tacrolimus pharmacokinetics directly after lung transplantation (LuTx) may increase the risk for acute kidney injury (AKI) and transplant rejection. The primary objective was ...
  • Subphenotypes in critical illness: a priori biological rationale is key 
    MARS Consortium (Springer-Verlag, 2024-02)
  • International Survey on Mechanical Ventilation During Extracorporeal Membrane Oxygenation 
    On behalf of the Dutch ECLS Study group (Lippincott Williams & Wilkins, 2024-04-01)
    The optimal ventilation strategy for patients on extracorporeal membrane oxygenation (ECMO) remains uncertain. This survey reports current mechanical ventilation strategies adopted by ECMO centers worldwide. An international, ...
  • Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study 
    MARS Consortium (Springer-Verlag GmbH and Co. KG, 2024-03-27)
    Background: Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative ...
  • Examining pancreatic stone protein response in ICU-acquired bloodstream infections: a matched event analysis 
    Verlaan, Diede; Derde, Lennie P G; van der Poll, Tom; Bonten, Marc J M; Cremer, Olaf L (Springer Science + Business Media, 2024-05-28)
    BACKGROUND: Pancreatic stone protein (PSP) exhibits potential as a plasma biomarker for infection diagnosis and risk stratification in critically ill patients, but its significance in nosocomial infection and intensive ...
  • Advanced waveform analysis of diaphragm surface EMG allows for continuous non-invasive assessment of respiratory effort in critically ill patients at different PEEP levels 
    Warnaar, R S P; Cornet, A D; Beishuizen, A; Moore, C M; Donker, D W; Oppersma, E (Springer Science + Business Media, 2024-06-09)
    BACKGROUND: Respiratory effort should be closely monitored in mechanically ventilated ICU patients to avoid both overassistance and underassistance. Surface electromyography of the diaphragm (sEMGdi) offers a continuous ...
  • Predicting the outcome in poisoned patients: look at the past! 
    Zwaag, Samanta M; Hunault, Claudine C; de Lange, Dylan W (Informa Healthcare, 2024-04-29)
    INTRODUCTION: When predicting future events, we often rely on analyzing past occurrences and projecting them forward. This methodology is crucial in various fields, including toxicology, in which predicting outcomes in ...
  • Clinical impact and risk factors for colonization with extended-spectrum β-lactamase-producing bacteria in the intensive care unit 
    Razazi, Keyvan; Derde, Lennie P G; Verachten, Marine; Legrand, Patrick; Lesprit, Philippe; Brun-Buisson, Christian (Springer-Verlag, 2012-11)
    PURPOSE: The changed epidemiology of extended spectrum beta-lactamases (ESBL), the spread to the community and the need for prudent use of carbapenems require updated knowledge of risk factors for colonization with ...
  • Anaesthetic depth and complications after major surgery: an international, randomised controlled trial 
    Australian and New Zealand College of Anaesthetists Clinical Trials Network; Balanced Anaesthesia Study Group (Elsevier, 2019-11-23)
    Background: An association between increasing anaesthetic depth and decreased postoperative survival has been shown in observational studies; however, evidence from randomised controlled trials is lacking. Our aim was to ...
  • Antimicrobial resistance on the move: Computational methods to identify and reconstruct mobile genetic elements contributing to AMR dissemination 
    Kerkvliet, Jesse (Utrecht University, 2024-07-09)
    Antimicrobial resistance (AMR) is a growing challenge for public health. In 2019 alone, 1.27 million people have died of causes directly linked to infections caused by resistant bacteria. This problem does not only focus ...
  • Irradiation of colorectal and liver tumors: Novel applications and mechanisms of resistance 
    Andel, Daan (Utrecht University, 2024-07-09)
    Radiation therapy is a cornerstone in cancer treatment, but for a large proportion of cancer patients it will prove ineffective. This thesis explores how radioresistance develops as well as a technique called radiation ...
  • JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study 
    Fischer, Marco; Olbrich, Peter; Hadjadj, Jérôme; Aumann, Volker; Bakhtiar, Shahrzad; Barlogis, Vincent; von Bismarck, Philipp; Bloomfield, Markéta; Booth, Claire; Buddingh, Emmeline P.; Cagdas, Deniz; Castelle, Martin; Chan, Alice Y.; Chandrakasan, Shanmuganathan; Chetty, Kritika; Cougoul, Pierre; Crickx, Etienne; Dara, Jasmeen; Deyà-Martínez, Angela; Farmand, Susan; Formankova, Renata; Gennery, Andrew R.; Gonzalez-Granado, Luis Ignacio; Hagin, David; Hanitsch, Leif Gunnar; Hanzlikovà, Jana; Hauck, Fabian; Ivorra-Cortés, José; Kisand, Kai; Kiykim, Ayca; Körholz, Julia; Leahy, Timothy Ronan; van Montfrans, Joris; Nademi, Zohreh; Nelken, Brigitte; Parikh, Suhag; Plado, Silvi; Ramakers, Jan; Redlich, Antje; Rieux-Laucat, Frédéric; Rivière, Jacques G.; Rodina, Yulia; Júnior, Pérsio Roxo; Salou, Sarah; Schuetz, Catharina; Shcherbina, Anna; Slatter, Mary A.; Touzot, Fabien; Unal, Ekrem; Lankester, Arjan C.; Burns, Siobhan; Seppänen, Mikko R.J.; Neth, Olaf; Albert, Michael H.; Ehl, Stephan; Neven, Bénédicte; Speckmann, Carsten (Mosby Inc., 2024-01)
    Background: Inborn errors of immunity (IEI) with dysregulated JAK/STAT signaling present with variable manifestations of immune dysregulation and infections. Hematopoietic stem cell transplantation (HSCT) is potentially ...
  • Which low urgent triaged febrile children are suitable for a fast track? An observational European study 
    Tan, Chantal D.; Vermont, Clementien L.; Zachariasse, Joany M.; Von Both, Ulrich; Carrol, Enitan D.; Eleftheriou, Irini; Emonts, Marieke; Van Der Flier, Michiel; Herberg, Jethro; Kohlmaier, Benno; Levin, Michael; Lim, Emma; Maconochie, Ian K.; Martinon-Torres, Federico; Nijman, Ruud G.; Pokorn, Marko; Rivero-Calle, Irene; RudzÄa Te, Aleksandra; Tsolia, Maria; Zenz, Werner; Zavadska, Dace; Moll, Henriette A. (BMJ Publishing Group, 2024-04)
    Background The number of paediatric patients visiting the ED with non-urgent problems is increasing, leading to poor patient flow and ED crowding. Fast track aims to improve the efficiency of evaluation and discharge of ...
  • Methotrexate for juvenile idiopathic arthritis 
    Tan, Joachim; Renton, William D.; Whittle, Samuel L.; Takken, Tim; Johnston, Renea V.; Tiller, Georgina; Munro, Jane; Buchbinder, Rachelle (John Wiley & Sons Inc., 2024-02-09)
    Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. Methotrexate has broad immunomodulatory properties and is the most commonly used disease-modifying antirheumatic drug ...
  • Adoption of C-reactive protein rapid tests for the management of acute childhood infections in hospitals in the Netherlands and England: a comparative health systems analysis 
    Dewez, Juan Emmanuel; Nijman, Ruud G.; Fitchett, Elizabeth J.A.; Li, Edmond C.; Luu, Queena F.; Lynch, Rebecca; Emonts, Marieke; de Groot, Ronald; van der Flier, Michiel; Philipsen, Ria; Ettelt, Stefanie; Yeung, Shunmay (BioMed Central, 2024-03-19)
    Background: The adoption of C-reactive protein point-of-care tests (CRP POCTs) in hospitals varies across Europe. We aimed to understand the factors that contribute to different levels of adoption of CRP POCTs for the ...
  • Diagnosis, treatment, and surveillance of Diamond-Blackfan anaemia syndrome: international consensus statement 
    Wlodarski, Marcin W.; Vlachos, Adrianna; Farrar, Jason E.; Da Costa, Lydie M.; Kattamis, Antonis; Dianzani, Irma; Belendez, Cristina; Unal, Sule; Tamary, Hannah; Pasauliene, Ramune; Pospisilova, Dagmar; de la Fuente, Josu; Iskander, Deena; Wolfe, Lawrence; Liu, Johnson M.; Shimamura, Akiko; Albrecht, Katarzyna; Lausen, Birgitte; Bechensteen, Anne Grete; Tedgard, Ulf; Puzik, Alexander; Quarello, Paola; Ramenghi, Ugo; Bartels, Marije; Hengartner, Heinz; Farah, Roula A.; Al Saleh, Mahasen; Hamidieh, Amir Ali; Yang, Wan; Ito, Etsuro; Kook, Hoon; Ovsyannikova, Galina; Kager, Leo; Gleizes, Pierre Emmanuel; Dalle, Jean Hugues; Strahm, Brigitte; Niemeyer, Charlotte M.; Lipton, Jeffrey M.; Leblanc, Thierry M.; international Diamond-Blackfan anaemia syndrome guideline panel (Lancet Publishing Group, 2024-05)
    Diamond-Blackfan anaemia (DBA), first described over 80 years ago, is a congenital disorder of erythropoiesis with a predilection for birth defects and cancer. Despite scientific advances, this chronic, debilitating, and ...
  • Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children from Other Pediatric Infectious and Inflammatory Diseases 
    Yeoh, Sophya; Estrada-Rivadeneyra, Diego; Jackson, Heather; Keren, Ilana; Galassini, Rachel; Cooray, Samantha; Shah, Priyen; Agyeman, Philipp; Basmaci, Romain; Carrol, Enitan; Emonts, Marieke; Fink, Colin; Kuijpers, Taco; Martinon-Torres, Federico; Mommert-Tripon, Marine; Paulus, Stephane; Pokorn, Marko; Rojo, Pablo; Romani, Lorenza; Schlapbach, Luregn; Schweintzger, Nina; Shen, Ching Fen; Tsolia, Maria; Usuf, Effua; Van Der Flier, Michiel; Vermont, Clementien; Von Both, Ulrich; Yeung, Shunmay; Zavadska, Dace; Coin, Lachlan; Cunnington, Aubrey; Herberg, Jethro; Levin, Michael; Kaforou, Myrsini; Hamilton, Shea (Lippincott Williams & Wilkins, 2024-05-01)
    Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious hyperinflammatory complication following infection with severe acute respiratory syndrome coronavirus 2. The mechanisms underpinning ...
  • Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival 
    Vallée, Tanja C.; Glasmacher, Jannik S.; Buchner, Hannes; Arkwright, Peter D.; Behrends, Uta; Bondarenko, Anastasia; Browning, Michael J.; Buchbinder, David; Cattoni, Alessandro; Chernyshova, Liudmyla; Ciznar, Peter; Cole, Theresa; Czogała, Wojciech; Dueckers, Gregor; Edgar, John David M.; Erbey, Fatih; Fasth, Anders; Ferrua, Francesca; Formankova, Renata; Gambineri, Eleonora; Gennery, Andrew R.; Goldman, Frederick D.; Gonzalez-Granado, Luis I.; Heilmann, Carsten; Heiskanen-Kosma, Tarja; Juntti, Hanna; Kainulainen, Leena; Kanegane, Hirokazu; Karaca, Neslihan E.; Kilic, Sara S.; Klein, Christoph; Kołtan, Sylwia; Kondratenko, Irina; Meyts, Isabelle; Nasrullayeva, Gulnara M.; Notarangelo, Lucia D.; Pasic, Srdjan; Pellier, Isabelle; Pignata, Claudio; Misbah, Siraj; Schulz, Ansgar; Segundo, Gesmar R.; Shcherbina, Anna; Slatter, Mary; Sokolic, Robert; Soler-Palacin, Pere; Stepensky, Polina; van Montfrans, Joris M.; Ryhänen, Samppa; Wolska-Kuśnierz, Beata; Ziegler, John B.; Zhao, Xiaodong; Aiuti, Alessandro; Ochs, Hans D.; Albert, Michael H. (Elsevier, 2024-06-13)
    Wiskott-Aldrich syndrome (WAS) is a multifaceted monogenic disorder with a broad disease spectrum and variable disease severity and a variety of treatment options including allogeneic hematopoietic stem cell transplantation ...
  • Cardiac MRI in diagnosis, prognosis, and follow-up of hypertrophic cardiomyopathy in children: current perspectives 
    Spaapen, Tessa O M; Bohte, Anneloes E; Slieker, Martijn G; Grotenhuis, Heynric B (Oxford University Press, 2024-05-07)
    Hypertrophic Cardiomyopathy (HCM) is an inherited myocardial disease characterised by left ventricular hypertrophy, which carries an increased risk of life-threatening arrhythmias and sudden cardiac death. The age of ...
  • Impaired upper respiratory tract barrier function during postnatal development predisposes to invasive pneumococcal disease 
    Lokken-Toyli, Kristen L.; Aggarwal, Surya D.; Bee, Gavyn Chern Wei; de Steenhuijsen Piters, Wouter A.A.; Wu, Cindy; Chen, Kenny Zhi Ming; Loomis, Cynthia; Bogaert, Debby; Weiser, Jeffrey N. (Public Library of Science, 2024-05-08)
    Infants are highly susceptible to invasive respiratory and gastrointestinal infections. To elucidate the age-dependent mechanism(s) that drive bacterial spread from the mucosa, we developed an infant mouse model using the ...