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UMC Repository: Recent submissions

  • Trained Immunity in Primary Sjögren’s Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype 
    Huijser, Erika; van Helden-Meeuwsen, Cornelia G.; Grashof, Dwin G.B.; Tarn, Jessica R.; Brkic, Zana; Huisman, Josje M.A.; Wahadat, M. Javad; van de Werken, Harmen J.G.; Lopes, Ana P.; van Roon, Joel A.G.; van Daele, Paul L.A.; Kamphuis, Sylvia; Ng, Wan Fai; Bekkering, Siroon; Joosten, Leo A.B.; Dik, Willem A.; Versnel, Marjan A. (Frontiers Media S. A., 2022-07-04)
    Background: Trained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity ...
  • Interspecies commensal interactions have nonlinear impacts on host immunity 
    Rice, Tyler A; Bielecka, Agata A; Nguyen, Mytien T; Rosen, Connor E; Song, Deguang; Sonnert, Nicole D; Yang, Yi; Cao, Yiyun; Khetrapal, Varnica; Catanzaro, Jason R; Martin, Anjelica L; Rashed, Saleh A; Leopold, Shana R; Hao, Liming; Yu, Xuezhu; van Dijk, David; Ring, Aaron M; Flavell, Richard A; de Zoete, Marcel R; Palm, Noah W (Cell Press, 2022-07-13)
    The impacts of individual commensal microbes on immunity and disease can differ dramatically depending on the surrounding microbial context; however, the specific bacterial combinations that dictate divergent immunological ...
  • Patients’ experiences with an audio-visual intervention, the use of a tailored explanimation video in patients with bladder cancer 
    Wolters-Zwolle, Marjon; de Jongh, Marielle M.E.; van Elst, Maarten W.; Meijer, Richard P.; Vervoort, Sigrid C.J.M. (Elsevier, 2022-12)
    Objective: This qualitative study explored the experiences of patients with bladder cancer with a tailored ‘explanimation’ video (EV) as a supportive information tool used before and during treatment. Methods: Using a ...
  • Risicoprofiel diagnostisch proces 
    Van Der Bij, Akke K.; Van Aken, Maarten O.; Reijnders, Jurriën G P; Prinsen, Hubertus C M T; van den Heuvel, Marius; Cats, Ariane; te Riet, Joost; ten Berg, MJ; Verbree-Willemsen, Femke Ver; ten Broek, Marc; Zwaan, Laura (Nederlandse Vereniging voor Medische Microbiologie, 2023-09)
  • Is ductoscopie bij pathologische tepeluitvloed zinvol gebleken? 
    Makineli, Seher; Filipe, Mando D.; van Diest, Paul J.; Vriens, Menno R.; Witkamp, Arjen J. (Bohn Stafleu van Loghum, 2023)
    Pathological nipple discharge (PND) is a common complaint in women and is defined as spontaneous, unilateral (bloody or serous) nipple discharge from a single milk duct. In 5-10% of cases, there is an underlying (pre)malignancy, ...
  • Uitkomsten van hyperbolisch afbouwen van antidepressiva 
    Os, Jim van; Groot, peter C. (Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP), 2024-03-31)
    Outcomes of hyperbolic tapering of antidepressants Background In patients attempting to discontinue their antidepressant medication, there have been no prospective studies on patterns of withdrawal as a function of the ...
  • Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (Nature Communications, (2020), 11, 1, (728), 10.1038/s41467-019-13825-8) 
    Jiao, Wei; Atwal, Gurnit; Polak, Paz; Karlic, Rosa; Cuppen, Edwin; Getz, Gad; Danyi, Alexandra; de Ridder, Jeroen; Lolkema, Martijn P.; Steeghs, Neeltje; PCAWG Tumor Subtypes and Clinical Translation Working Group; PCAWG Consortium (Nature Publishing Group, 2022-12)
    In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortiumwere listed in the Supplementary Information; however, these members shouldhave been included in themainpaper.The ...
  • DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes 
    Fraszczyk, Eliza; Thio, Chris H.L.; Wackers, Paul; Dollé, Martijn E.T.; Bloks, Vincent W.; Hodemaekers, Hennie; Picavet, H. Susan; Stynenbosch, Marjolein; Verschuren, W. M.Monique; Snieder, Harold; Spijkerman, Annemieke M.W.; Luijten, Mirjam (Springer International Publishing AG, 2022-12)
    DNA methylation (DNAm) patterns across the genome changes during aging and development of complex diseases including type 2 diabetes (T2D). Our study aimed to estimate DNAm trajectories of CpG sites associated with T2D, ...
  • Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands 
    van den Hoogen, Lotus Leonie; Boer, Mardi; Postema, Abigail; de Rond, Lia; de Zeeuw-Brouwer, Mary lène; Pronk, Inge; Wijmenga-Monsuur, Alienke Jentien; Bijvank, Elske; Kruiper, Caitlyn; Beckers, Lisa; Maurik, Marjan Bogaard van; Zutt, Ilse; van Vliet, Jeffrey; van Bergen, Rianne; Kuijer, Marjan; Smits, Gaby; Verschuren, W. M.Monique; Picavet, H. Susan J.; van der Klis, Fiona Regina Maria; den Hartog, Gerco; van Binnendijk, Robert Samuel; Buisman, Anne Marie (Multidisciplinary Digital Publishing Institute, 2022-09)
    Vaccine-induced protection against severe COVID-19, hospitalization, and death is of the utmost importance, especially in the elderly. However, limited data are available on humoral immune responses following COVID-19 ...
  • The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic 
    Serigstad, Sondre; Markussen, Dagfinn L.; Ritz, Christian; Ebbesen, Marit H.; Knoop, Siri T.; Kommedal, Øyvind; Heggelund, Lars; Ulvestad, Elling; Bjørneklett, Rune O.; Grewal, Harleen M.S.; The CAPNOR Study Group (BioMed Central, 2022-09-30)
    Background: The COVID-19 pandemic was met with strict containment measures. We hypothesized that societal infection control measures would impact the number of hospital admissions for respiratory tract infections, as well ...
  • A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection 
    Andreakos, Evangelos; Abel, Laurent; Vinh, Donald C; Kaja, Elżbieta; Drolet, Beth A; Zhang, Qian; O'Farrelly, Cliona; Novelli, Giuseppe; Rodríguez-Gallego, Carlos; Haerynck, Filomeen; Prando, Carolina; Pujol, Aurora; COVID Human Genetic Effort; Su, Helen C; Casanova, Jean-Laurent; Spaan, András N (Nature Research, 2022-02)
    SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account ...
  • Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality Results from a Randomized Controlled Trial of ACE Inhibitors 
    ADVANCE Collaborative Group (Lippincott Williams & Wilkins, 2022-08)
    Background and objectives Hyperkalemia after starting renin-angiotensin system inhibitors has been shown to be subsequently associated with a higher risk of cardiovascular and kidney outcomes. However, whether to continue ...
  • Inflammatory potential of diet and pancreatic cancer risk in the EPIC study 
    Cayssials, Valerie; Buckland, Genevieve; Crous-Bou, Marta; Bonet, Catalina; Weiderpass, Elisabete; Skie, Guri; Aune, Dagfinn; Heath, Alicia; Nøst, Therese Haugdahl; Masala, Giovanna; Agnoli, Claudia; De Magistris, Maria Santucci; Bueno-de-Mesquita, Bas; Derksen, Jeroen; Huybrechts, Inge; Ferrari, Pietro; Franklin, Oscar; Bodén, Stina; Schulze, Matthias; Huerta, Jose Maria; Barricarte, Aurelio; Sacerdote, Carlotta; Amiano, Pilar; Tumino, Rosario; Molina-Montes, Esther; Tjønneland, Anne; Kyrø, Cecilie; Severi, Gianluca; Boutron-Ruault, Marie Christine; Rebours, Vinciane; Katzke, Verena; Agudo, Antonio; Jakszyn, Paula (Springer Science and Business Media Deutschland GmbH, 2022-08)
    Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to ...
  • Drop-offs in the isoniazid preventive therapy cascade among children living with HIV in western Kenya, 2015–2019 
    Onyango, Dickens Otieno; van der Sande, Marianne A.B.; Yuen, Courtney M.; Mecha, Jerphason; Matemo, Daniel; Oele, Elizabeth; Kinuthia, John; John-Stewart, Grace; LaCourse, Sylvia M. (International AIDS Society, 2022-08)
    Introduction: Isoniazid preventive therapy (IPT) can reduce the risk of tuberculosis (TB) in children living with HIV (CLHIV), but data on the outcomes of the IPT cascade in CLHIV are limited. Methods: We evaluated the IPT ...
  • Healthy lifestyle over the life course: Population trends and individual changes over 30 years of the Doetinchem Cohort Study 
    Schermer, Edith E.; Engelfriet, Peter M.; Blokstra, Anneke; Verschuren, W. M.Monique; Picavet, H. Susan J. (Frontiers Media S. A., 2022-09-09)
    For five health-related lifestyle factors (physical activity, weight, smoking, sleep, and alcohol consumption) we describe both population trends and individual changes over a period of 30 years in the same adult population. ...
  • Agent-based modeling of urban exposome interventions: prospects, model architectures, and methodological challenges 
    Sonnenschein, Tabea; Scheider, Simon; de Wit, G Ardine; Tonne, Cathryn C; Vermeulen, Roel (OUP, 2022-10-10)
    With ever more people living in cities worldwide, it becomes increasingly important to understand and improve the impact of the urban habitat on livability, health behaviors, and health outcomes. However, implementing ...
  • Correction to: Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance 
    Tack, Bieke; Phoba, Marie France; Van Puyvelde, Sandra; Kalonji, Lisette M.; Hardy, Liselotte; Barbé, Barbara; Van Der Sande, Marianne A.B.; Monsieurs, Elise; Deborggraeve, Stijn; Lunguya, Octavie; Jacobs, Jan (Oxford University Press, 2022-04-15)
    In the original publication of this manuscript [Tack B, Phoba M, Puyvelde SV et al. Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance. Clin Infect Dis. Volume 68 Supplement ...
  • Educating for Responsible Research Practice in Biomedical Sciences: Towards Learning Goals 
    Gerrits, Elianne M.; Bredenoord, Annelien L.; van Mil, Marc H.W. (2022-08)
    New developments in the field of biomedicine can have extensive implications for society. To steer research efforts in a responsible direction, biomedical scientists should contribute to a forward-looking ethical, and ...
  • Europe must come together to confront omicron 
    Valdez, André Calero; Iftekhar, Emil N.; Oliu-Barton, Miquel; Böhm, Robert; Cuschieri, Sarah; Czypionka, Thomas; Dumpis, Uga; Giordano, Giulia; Hanson, Claudia; Hel, Zdenek; Helova, Anna; Kickbusch, Ilona; Klimek, Peter; Kojan, Lilian; Kretzschmar, Mirjam; Krueger, Tyll; Krutzinna, Jenny; Lange, Berit; Lazarus, Jeffrey V.; Machado, Helena; McKee, Martin; Nagel, Kai; Perc, Matja; Petelos, Elena; Popivanov, Nedyu; Pradelski, Bary; Prainsack, Barbara; Schroeder, Kay; Tsiodras, Sotirios; Wilmes, Paul; Wolff, Guntram (BMJ Publishing Group, 2022-01-12)
  • Use of WATCH antibiotics prior to presentation to the hospital in rural Burkina Faso 
    Valia, Daniel; Ingelbeen, Brecht; Kaboré, Bérenger; Karama, Ibrahima; Peeters, Marjan; Lompo, Palpouguini; Vlieghe, Erika; Post, Annelies; Cox, Janneke; de Mast, Quirijn; Robert, Annie; van der Sande, Marianne A.B.; Villalobos, Hector Rodriguez; van der Ven, Andre; Tinto, Halidou; Jacobs, Jan (BioMed Central Ltd., 2022-04-13)
    Background: In low- and middle-income countries, the prevalence of antimicrobial resistance (AMR) is increasing. To control AMR, WHO recommends monitoring antibiotic use, in particular Watch antibiotics. These are critically ...