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UMC Repository: Recent submissions

  • Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis 
    Zhang, Sai; Cooper-Knock, Johnathan; Weimer, Annika K; Shi, Minyi; Moll, Tobias; Marshall, Jack N G; Harvey, Calum; Nezhad, Helia Ghahremani; Franklin, John; Souza, Cleide Dos Santos; Ning, Ke; Wang, Cheng; Li, Jingjing; Dilliott, Allison A; Farhan, Sali; Elhaik, Eran; Pasniceanu, Iris; Livesey, Matthew R; Eitan, Chen; Hornstein, Eran; Kenna, Kevin P; Veldink, Jan H; Ferraiuolo, Laura; Shaw, Pamela J; Snyder, Michael P; Project MinE ALS Sequencing Consortium (Cell Press, 2022-03-16)
    Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death. Despite heritability estimates of 52%, genome-wide association studies (GWASs) have discovered relatively few loci. We developed a ...
  • Optimized Dosing: The Next Step in Precision Medicine in Non-Small-Cell Lung Cancer 
    Boosman, René J.; Burgers, Jacobus A.; Smit, Egbert F.; Steeghs, Neeltje; van der Wekken, Anthonie J.; Beijnen, Jos H.; Huitema, Alwin D.R.; ter Heine, Rob (Adis, 2022-01)
    In oncology, and especially in the treatment of non-small-cell lung cancer (NSCLC), dose optimization is often a neglected part of precision medicine. Many drugs are still being administered in “one dose fits all” regimens ...
  • Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery 
    Guo, Shanshan; Cázarez-Márquez, Fernando; Jiao, Han; Foppen, Ewout; Korpel, Nikita L.; Grootemaat, Anita E.; Liv, Nalan; Gao, Yuanqing; Van Der Wel, Nicole; Zhou, Bing; Nie, Guangjun; Yi, Chun Xia (American Chemical Society, 2022-02-02)
    Microglia are the major innate immune cells in the brain and are essential for maintaining homeostasis in a neuronal microenvironment. Currently, a genetic tool to modify microglial gene expression in specific brain regions ...
  • Generalizability of randomized controlled trials in heart failure with reduced ejection fraction 
    Lim, Yvonne Mei Fong; Molnar, Megan; Vaartjes, Ilonca; Savarese, Gianluigi; Eijkemans, Marinus J C; Uijl, Alicia; Vradi, Eleni; Suzart-Woischnik, Kiliana; Brugts, Jasper J; Brunner-La Rocca, Hans-Peter; Blanc-Guillemaud, Vanessa; Couvelard, Fabrice; Baudier, Claire; Dyszynski, Tomasz; Waechter, Sandra; Lund, Lars H; Hoes, Arno W; Tyl, Benoit; Asselbergs, Folkert W; Gerlinger, Christoph; Grobbee, Diederick E; Cronin, Maureen; Koudstaal, Stefan (Oxford University Press, 2022-11-01)
    Background Heart failure (HF) trials have stringent inclusion and exclusion criteria, but limited data exist regarding generalizability of trials. We compared patient characteristics and outcomes between patients with HF ...
  • Causative Pathogens Do Not Differ between Early, Delayed or Late Fracture-Related Infections 
    Corrigan, Ruth A; Sliepen, Jonathan; Dudareva, Maria; IJpma, Frank F A; Govaert, Geertje; Atkins, Bridget L; Rentenaar, Rob; Wouthuyzen-Bakker, Marjan; McNally, Martin (Multidisciplinary Digital Publishing Institute (MDPI), 2022-07-14)
    Fracture-related infections (FRIs) are classically considered to be early (0−2 weeks), delayed (3−10 weeks) or late (>10 weeks) based on hypothesized differences in causative pathogens and biofilm formation. Treatment ...
  • Age differences in functioning and contextual factors in community-dwelling stroke survivors: A national cross-sectional survey 
    Olafsdottir, Steinunn A.; Hjaltadottir, Ingibjörg; Galvin, Rose; Hafsteinsdottir, Thora B.; Jonsdottir, Helga; Arnadottir, Solveig A. (Public Library of Science, 2022-08)
    Background Our study aimed to map functioning and contextual factors among community-dwelling stroke survivors after first stroke, based on the International Classification of Functioning, Disability and Health (ICF), and ...
  • Causes, survival rates, and short-term outcomes of preterm births in a tertiary hospital in a low resource setting: An observational cohort study 
    Mocking, Martina; Adu-Bonsaffoh, Kwame; Osman, Kwabena A; Tamma, Evelyn; Ruiz, Alexa M; van Asperen, Ruth; Oppong, Samuel A; Kleinhout, Mirjam Y; Gyamfi-Bannerman, Cynthia; Browne, Joyce L (Frontiers Media S. A., 2023-02-02)
    Background: Prematurity is the most important cause of death among children under the age of five years. Globally, most preterm births occur in Sub-Saharan Africa. Subsequent prematurity leads to significant neonatal ...
  • Exploring the difference between men and women in physical functioning: How do sociodemographic, lifestyle- and health-related determinants contribute? 
    Sialino, Lena Dirkje; Picavet, H. Susan J.; Wijnhoven, Hanneke A.H.; Loyen, Anne; Verschuren, W. M.Monique; Visser, Marjolein; Schaap, Laura S.; van Oostrom, Sandra H. (BioMed Central, 2022-07-22)
    Background: To explore whether differences between men and women in the sensitivity to (strength of the association) and/or in the exposure to determinants (prevalence) contribute to the difference in physical functioning, ...
  • How nurses support self-management of hospitalized patients through verbal communication: a qualitative study 
    Otter, Caroline E.M.; Keers, Joost C.; Reker, Celeste; Smit, Jakobus; Schoonhoven, Lisette; de Man-van Ginkel, Janneke M. (BioMed Central, 2022-11-28)
    Background: Patients’ self-management of the implications of their disease(s) is becoming increasingly important. Research shows that hospitalization disrupts established self-management routines. Nurses can play an important ...
  • Obesity in relation to cardiorenal function 
    Nguyen, Isabel T.N.; Joles, Jaap A.; Verhaar, Marianne C.; Lamb, Hildo J.; Dekkers, Ilona A. (Elsevier, 2022-01-01)
    Obesity is a growing pandemic with serious impact on renal and cardiovascular function. Complex associations between obesity and cardiorenal function involving different pathological pathways, also referred to as obesity-related ...
  • Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR) 
    Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn; Ebbesen, Marit H; Kommedal, Øyvind; Bjørneklett, Rune O; Heggelund, Lars; Clark, Tristan W; van Werkhoven, Cornelis H; Knoop, Siri T; Ulvestad, Elling; Grewal, Harleen M S; CAPNOR Study Group (BioMed Central, 2022-08-01)
    BACKGROUND: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ...
  • Surgical Menopause and Bilateral Oophorectomy: Effect of Estrogen-Progesterone and Testosterone Replacement Therapy on Psychological Well-Being and Sexual Functioning; A Systematic Literature Review 
    Stuursma, Annechien; Lanjouw, Lieke; Idema, Demy L; de Bock, Geertruida H; Mourits, Marian J E (2022-12-01)
    Background: Besides experiencing vasomotor symptoms, after surgical menopause and bilateral salpingo-oophorectomy (BSO), women experience moderate to severe psychological and sexual symptoms. Aims: To systematically review ...
  • Evaluation of nonalcoholic fatty liver disease (NAFLD) in severe obesity using noninvasive tests and imaging techniques 
    Theel, Willy; Boxma-de Klerk, Bianca M.; Dirksmeier-Harinck, Femme; van Rossum, Elisabeth F.C.; Kanhai, Danny A.; Apers, Jan; van Dalen, Bas M.; de Knegt, Robert J.; Holleboom, Anthony G.; Tushuizen, Maarten E.; Grobbee, Diederick E.; Wiebolt, Janneke; Castro Cabezas, Manuel (Wiley-Blackwell, 2022-08)
    The prevalence of nonalcoholic fatty liver disease (NAFLD) and the more severe and inflammatory type, nonalcoholic steatohepatitis (NASH), is increasing rapidly. Especially in high-risk patients, that is those with obesity, ...
  • Neonatal Nursing: A Global Perspective 
    Child Health; Neonatologie Zorg; Infection & Immunity; MS Neonatologie; Petty, Julia; Jones, Tracey; den Hoogen, Agnes van; Walker, Karen; Kenner, Carole (Springer International Publishing, 2022-01-01)
    This textbook is written in line with the Council of International Neonatal Nurses, Inc. (COINN) vision for global unity for neonatal nursing. The core values and goals of COINN are based on excellence and advocacy for ...
  • Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries 
    Bots, Sophie H.; Riera-Arnau, Judit; Belitser, Svetlana V.; Messina, Davide; Aragón, Maria; Alsina, Ema; Douglas, Ian J.; Durán, Carlos E.; García-Poza, Patricia; Gini, Rosa; Herings, Ron M.C.; Huerta, Consuelo; Sisay, Malede Mequanent; Martín-Pérez, Mar; Martin, Ivonne; Overbeek, Jetty A.; Paoletti, Olga; Pallejà-Millán, Meritxell; Schultze, Anna; Souverein, Patrick; Swart, Karin M.A.; Villalobos, Felipe; Klungel, Olaf H.; Sturkenboom, Miriam C.J.M. (Frontiers Media S. A., 2022-11-24)
    Background: Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity of events, especially in age- and sex-stratified analyses. Methods: Population-based ...
  • Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch 
    Cornel, Annelisa M.; Dunnebach, Ester; Hofman, Damon A.; Das, Sanjukta; Sengupta, Satyaki; Van Den Ham, Femke; Wienke, Judith; Strijker, Josephine G.M.; Van Den Beemt, Denise A.M.H.; Essing, Anke H.W.; Koopmans, Bianca; Engels, Sem A.G.; Lo Presti, Vania; Szanto, Celina S.; George, Rani E.; Molenaar, Jan J.; Van Heesch, Sebastiaan; Dierselhuis, Miranda P.; Nierkens, S. (BioMed Central Ltd., 2022-12-15)
    Background Immunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL. We aimed to ...
  • Regional heterogeneity of malaria prevalence and associated risk factors among children under five in Togo: evidence from a national malaria indicators survey 
    Kombate, Gountante; Gmakouba, Wakpaouyare; Scott, Susana; Azianu, Komi Ameko; Ekouevi, Didier Koumavi; van der Sande, Marianne A.B. (BioMed Central, 2022-06-03)
    Background: Malaria remains a major cause of morbidity and death among children less than 5 years of age. In Togo, despite intensification of malaria control interventions, malaria remained highly prevalent, with significant ...
  • Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop 
    Paolini, Lucia; Monguio-Tortajada, Marta; Costa, Marta; Antenucci, Fabio; Barilani, Mario; Clos-Sansalvador, Marta; Cronemberger Andrade, Andre; Driedonks, Tom; Giancaterino, Sara; Kronstadt, Stephanie; Mizenko, Rachel; Nawaz, Muhammed; Osteikoetxea, Xabier; Pereira, Carla; Shrivastava, Surya; Toftegaard Boysen, Anders; van de Wakker, Simon; van Herwijnen, Martijn J C; Wang, Xiaoqin; Watson, Dionysios; Gimona, Mario; Kaprakis-Liaskos, Maria; Konstantinov, Konstantin; Lim, Sai Kiang; Meisner-Kober, Nicole C.; Stork, Michiel; Nejsum, Peter; Radeghieri, Annalisa; Rohde, Eva; Touzet, Nicolas; Wauben, Marca H M; Witwer, Kenneth; Bongiovanni, Antonella; Bergese, Paolo (John Wiley & Sons Inc., 2022-10)
    Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles ...
  • Off-target effects of bacillus Calmette–Guérin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19 
    Messina, Nicole L.; Germano, Susie; McElroy, Rebecca; Rudraraju, Rajeev; Bonnici, Rhian; Pittet, Laure F.; Neeland, Melanie R.; Nicholson, Suellen; Subbarao, Kanta; Curtis, Nigel; the BRACE trial (Nature Publishing Group, 2022)
    Background and objectives: Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette–Guérin (BCG) vaccination might be an accessible early intervention to boost protection ...
  • EUS-guided Drainage of Postoperative Fluid Collections 
    Bogte, Auke; Vleggaar, Frank P. (Springer Nature, 2022-01-01)
    EUS-guided postoperative drainage (EUS-POD) of postoperative fluid collections (POFCs) is increasingly popular as an alternative to percutaneous drainage in the management of patients with fluid collections after surgery. ...