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UMC Repository: Recent submissions

  • Leading causes of death and high mortality rates in an HIV endemic setting (Kisumu county, Kenya, 2019) 
    Waruru, Anthony; Onyango, Dickens; Nyagah, Lilly; Sila, Alex; Waruiru, Wanjiru; Sava, Solomon; Oele, Elizabeth; Nyakeriga, Emmanuel; Muuo, Sheru W.; Kiboye, Jacqueline; Musingila, Paul K.; van der Sande, Marianne A.B.; Massawa, Thaddeus; Rogena, Emily A.; DeCock, Kevin M.; Young, Peter W. (Public Library of Science, 2022-01)
    Background In resource-limited settings, underlying causes of death (UCOD) often are not ascertained systematically, leading to unreliable mortality statistics. We reviewed medical charts to establish UCOD for decedents ...
  • Immune Complex Glomerulonephritis in a Patient with Myelodysplastic Syndrome with Ring Sideroblasts Treated with Luspatercept 
    Delanghe, Sigurd; Nguyen, Tri Q; Mazure, Dominiek; Dendooven, Amélie; Speeckaert, Marijn M (MDPI AG, 2023-01)
    Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders distinguished by dysplastic bone marrow and peripheral blood cells, ineffective hematopoiesis, and an increased risk of developing acute myeloid ...
  • Controversies and evidence on Chlamydia testing and treatment in asymptomatic women and men who have sex with men: a narrative review 
    Dukers-Muijrers, Nicole H.T.M.; Evers, Ymke J.; Hoebe, Christian J.P.A.; Wolffs, Petra F.G.; de Vries, Henry J.C.; Hoenderboom, Bernice; van der Sande, Marianne A.B.; Heijne, Janneke; Klausner, Jeffrey D.; Hocking, Jane S.; van Bergen, Jan (BioMed Central, 2022-03-14)
    Background: Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection (STI) worldwide. CT is mainly asymptomatic. Test-and-treat strategies are widely implemented to prevent transmission and ...
  • Sex-specific and age-specific incidence of ischaemic heart disease, atrial fibrillation and heart failure in community patients with chronic obstructive pulmonary disease 
    Groenewegen, Amy; Zwartkruis, Victor W.; Smit, Lennart J.; de Boer, Rudolf A.; Rienstra, Michiel; Hoes, Arno W.; Hollander, Monika; Rutten, Frans H. (BMJ Publishing Group, 2022-12-30)
    OBJECTIVE: To estimate the incidence of ischaemic heart disease, atrial fibrillation and heart failure in community patients with or without chronic obstructive pulmonary disease (COPD). METHODS: For this population-based ...
  • Care-seeking behaviour among febrile children under five in Togo 
    Kombate, Gountante; Cakpo, Gbènonminvo Enoch; Azianu, Komi Ameko; Labité, Matè Alonyenyo; van der Sande, Marianne A.B. (BioMed Central, 2022-11-17)
    Background: Fever is one of the warning signs of poor health in children. Care-seeking in febrile children is importance in reducing child deaths and morbidity. This care-seeking by parents in children with fever is however ...
  • Using random forest to identify longitudinal predictors of health in a 30-year cohort study 
    Loef, Bette; Wong, Albert; Janssen, Nicole A.H.; Strak, Maciek; Hoekstra, Jurriaan; Picavet, H. Susan J.; Boshuizen, H. C.Hendriek; Verschuren, W. M.Monique; Herber, Gerrie Cor M. (Nature Publishing Group, 2022-06-20)
    Due to the wealth of exposome data from longitudinal cohort studies that is currently available, the need for methods to adequately analyze these data is growing. We propose an approach in which machine learning is used ...
  • Hyperpolypharmacy is a predictor of mortality after left ventricular assist device (LVAD) implantation 
    Dautzenberg, Lauren; Numan, Lieke; Knol, Wilma; Gianoli, Monica; van der Meer, Manon G.; Troost-Oppelaar, Anne Marie; Westendorp, Aline F.; Emmelot-Vonk, Marielle H.; van Laake, Linda W.; Koek, Huiberdina L. (Elsevier, 2022-12)
    Background: The prevalence of (hyper)polypharmacy in patients on left ventricular assist device (LVAD) support and its effect on clinical outcomeis unknown. Therefore, we aimed to determine the prevalence of (hyper)polypharmacy ...
  • Moral distress among nurses involved in life-prolonging treatments in patients with a short life expectancy: A qualitative interview study 
    Arends, Susanne A M; Steenbergen, Milou; Thodé, Maureen; Francke, Anneke L; Jongerden, Irene P (Elsevier Ireland Ltd, 2022-07)
    OBJECTIVE: To explore whether nurses in hospital settings experience moral distress when involved in potentially life-prolonging treatments in adults with a short life expectancy. METHODS: A qualitative study using ...
  • Autonomous patient consent for anaesthesia without preoperative consultation: a qualitative feasibility study including low-risk procedures 
    Marsman, Marije; van den Beuken, Wisse M.F.; van Klei, Wilton A.; Kappen, Teus H. (Elsevier, 2022-09)
    Background: Informed consent for anaesthesia is mandatory and requires provision of information and subsequent consent during consultation between anaesthesiologist and patient. Although information can be provided in an ...
  • Drivers of Routine and Outbreak Vaccination Uptake in the Western Democratic Republic of Congo: An Exploratory Study in Ten Health Zones 
    Peckeu-Abboud, Laurene; Mangoni, Patrick; Chammam, Kaouther; Kwete, Papy; Lupola, Patrick Mutombo; Vanlerberghe, Veerle; Yango, Jepsy; Meudec, Marie; Ifufa, Christian; van der Sande, Marianne A.B.; Ntwan, Joule Madinga; Mbala, Placide (Multidisciplinary Digital Publishing Institute, 2022-07)
    We performed a cross-sectional survey on vaccination-related knowledge, attitudes, and practices (KAP) among randomly selected parents of <5 years-old children, elderly populations (aged ≥ 55 years), and health care workers ...
  • Sugar addiction: An Achilles’ heel of auto-immune diseases? 
    Zaiss, Dietmar M.W.; Coffer, Paul J. (Cell Press, 2022-04-05)
    In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4+ T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent ...
  • Pathology of twinning 
    Nikkels, Peter G.J. (Springer International Publishing, 2022-01-01)
    Perinatal mortality and morbidity is three to seven times higher in twin pregnancies compared to singletons due to a higher incidence of antepartum complications, preterm birth and uteroplacental insufficiency. In comparison ...
  • TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions 
    Hijazi, Hadia; Reis, Linda M; Pehlivan, Davut; Bernstein, Jonathan A; Muriello, Michael; Syverson, Erin; Bonner, Devon; Estiar, Mehrdad A; Gan-Or, Ziv; Rouleau, Guy A; Lyulcheva, Ekaterina; Greenhalgh, Lynn; Tessarech, Marine; Colin, Estelle; Guichet, Agnès; Bonneau, Dominique; van Jaarsveld, R H; Lachmeijer, A M A; Ruaud, Lyse; Levy, Jonathan; Tabet, Anne-Claude; Ploski, Rafal; Rydzanicz, Małgorzata; Kępczyński, Łukasz; Połatyńska, Katarzyna; Li, Yidan; Fatih, Jawid M; Marafi, Dana; Rosenfeld, Jill A; Coban-Akdemir, Zeynep; Bi, Weimin; Gibbs, Richard A; Hobson, Grace M; Hunter, Jill V; Carvalho, Claudia M B; Posey, Jennifer E; Semina, Elena V; Lupski, James R (Cell Press, 2022-12-01)
    An Xq22.2 region upstream of PLP1 has been proposed to underly a neurological disease trait when deleted in 46,XX females. Deletion mapping revealed that heterozygous deletions encompassing the smallest region of overlap ...
  • The skeletal system 
    Nikkels, Peter G.J. (Springer International Publishing, 2022-01-01)
    Skeletal dysplasias are a group of disorders with a disturbance in development and or growth of cartilage and/or bone. Epiphysis, metaphysis and/or diaphysis of long bones are affected in a generalised manner with or without ...
  • Iatrogenic disease 
    Nikkels, Peter G.J. (Springer International Publishing, 2022-01-01)
    Injury is a feature of all medical practice but it is perhaps nowhere more accepted as an unavoidable consequence of therapy than in obstetric and neonatal medicine. Treatment is usually beneficial but therapeutic procedures ...
  • A short history of the European Association of Preventive Cardiology (EAPC) 
    De Backer, Guy; Perk, Joep; Wood, David; Gielen, Stephan; Pelliccia, Antonio; Grobbee, Diederick; Dendale, Paul; Saner, Hugo (Oxford University Press, 2022-07-01)
    The EAPC is now fit to address future challenges with a unified organization and strong multidisciplinary leadership together with the EJPC, the annual ESC Preventive Cardiology Congress, strong representation of preventive ...
  • Nasal DNA methylation at three CpG sites predicts childhood allergic disease 
    van Breugel, Merlijn; Qi, Cancan; Xu, Zhongli; Pedersen, Casper Emil T.; Petoukhov, Ilya; Vonk, Judith M.; Gehring, Ulrike; Berg, Marijn; Bügel, Marnix; Carpaij, Orestes A.; Forno, Erick; Morin, Andréanne; Eliasen, Anders U.; Jiang, Yale; van den Berge, Maarten; Nawijn, Martijn C.; Li, Yang; Chen, Wei; Bont, Louis J.; Bønnelykke, Klaus; Celedón, Juan C.; Koppelman, Gerard H.; Xu, Cheng Jian (Nature Publishing Group, 2022-12)
    Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of allergen-specific ...
  • Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Months after a Diagnosis of COVID-19 
    ERACODA Collaborators (Lippincott Williams & Wilkins, 2022-05-01)
    Background. Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)-related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in ...
  • Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy 
    Cueto-Ureña, Cristina; Mocholí, Enric; Escrivá-Fernández, Josep; González-Granero, Susana; Sánchez-Hernández, Sabina; Solana-Orts, Amalia; Ballester-Lurbe, Begoña; Benabdellah, Karim; Guasch, Rosa M.; García-Verdugo, José Manuel; Martín, Francisco; Coffer, Paul J.; Pérez-Roger, Ignacio; Poch, Enric (Frontiers Media S. A., 2022-06-27)
    Autophagy is a highly conserved process that mediates the targeting and degradation of intracellular components to lysosomes, contributing to the maintenance of cellular homeostasis and to obtaining energy, which ensures ...
  • Relation Between Plasma Proteomics Analysis and Major Adverse Cardiovascular Events in Patients With Stable Coronary Artery Disease 
    Dregoesc, Mihaela Ioana; Ţigu, Adrian Bogdan; Bekkering, Siroon; van der Heijden, Charlotte D.C.C.; Bolboacǎ, Sorana Daniela; Joosten, Leo A.B.; Visseren, Frank L.J.; Netea, Mihai G.; Riksen, Niels P.; Iancu, Adrian Corneliu (Frontiers Media S. A., 2022-02-08)
    Objective: Despite the advances in the control of traditional risk factors, coronary artery disease (CAD) remains the greatest cause of morbidity and mortality. Our aim was to establish the relation between plasma proteomics ...