A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
Andreakos, Evangelos; Abel, Laurent; Vinh, Donald C; Kaja, Elżbieta; Drolet, Beth A; Zhang, Qian; O'Farrelly, Cliona; Novelli, Giuseppe; Rodríguez-Gallego, Carlos; Haerynck, Filomeen; Prando, Carolina; Pujol, Aurora; COVID Human Genetic Effort; Su, Helen C; Casanova, Jean-Laurent; Spaan, András N
(2022) Nature immunology, volume 23, issue 2, pp. 159 - 164
(Article)
Abstract
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown.
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Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
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Keywords: Animals, COVID-19/genetics, Disease Resistance/genetics, Genetic Heterogeneity, Genetic Predisposition to Disease, Host-Pathogen Interactions, Humans, Phenotype, Protective Factors, Risk Assessment, Risk Factors, SARS-CoV-2/immunology, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
ISSN: 1529-2908
Publisher: Nature Research
Note: Publisher Copyright: © 2021, Springer Nature America, Inc.
(Peer reviewed)