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UMC Repository: Recent submissions

  • Exploring pathways to psychosis:: Childhood trauma as the invisible backpack 
    Begemann, M.J.H. (Utrecht University, 2017-09-06)
    Schizophrenia and related psychotic disorders have a severe impact on the lives of patients and the people close to them. Psychotic symptoms include hearing voices that others cannot hear, and the conviction that others ...
  • EEG in delirium 
    Numan, T. (Utrecht University, 2017-09-21)
    Delirium is an acute disturbance of cognition and attention which fluctuates during the day. The incidence of delirium is high, especially in critically ill and elderly patients. However, the pathophysiology is not fully ...
  • Integrated birth care: a Triple Aim: Quality of birth centre care in the Netherlands 
    Boesveld, I.C. (Utrecht University, 2017-10-03)
    Growing demand for health services, fragmentation of services, changing health needs, and increasing influence of economic, political and social factors on health care delivery are steering policymakers to “integrated care” ...
  • Targeting inflammation in atherosclerosis and myocardial infarction 
    Ellenbroek, G.H.J.M. (Utrecht University, 2017-09-14)
    Ischaemic heart disease, also known as coronary artery disease (CAD), is one of the major causes of morbidity and mortality worldwide, with an estimated death rate of 7.4 million in 2012. The growing incidence of cardiovascular ...
  • Experiences of parents and physicians with palliative care for pediatric cancer patients 
    van der Geest, I.M.M. (Utrecht University, 2017-09-12)
    Approximately 25% of children diagnosed with cancer eventually die. In this thesis, the long-term experiences of parents and physicians with palliative care for pediatric cancer patients were explored using questionnaires. ...
  • How to measure nurses’ knowledge and attitude regarding older patients? 
    Dikken, Jeroen (Utrecht University, 2017-06-20)
    Background: Worldwide, people are aging. This demographic change results in an increase of older people admitted in hospitals. A growing number of registered nurses will encounter older patients in their daily work and a ...
  • Centraal Station 
    Chamuleau, SAJ (UMC Utrecht, 2017-03-10)
  • Comparing viral load metrics and evaluating their use for HIV surveillance 
    Bolijn, Renee; Op de Coul, Eline L M; van Sighem, Ard I; Blok, Willem L; Kretzschmar, Mirjam E; Heijne, Janneke C M; ATHENA National Observational HIV Cohort (W.B. Saunders Ltd, 2017-08)
    OBJECTIVES: To investigate the value of in-care viral load (ICVL) and other viral load (VL) metrics for HIV surveillance by comparing time trends and associations with numbers of new HIV diagnoses. METHODS: Data from 20,740 ...
  • Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial 
    de Rooij, Thijs; van Hilst, Jony; Vogel, Jantien A; van Santvoort, Hjalmar C; de Boer, Marieke T.; Boerma, Djamila; van den Boezem, Peter B.; Bonsing, Bert A.; Bosscha, Koop; Coene, Peter-Paul; Daams, Freek; van Dam, Ronald M.; Dijkgraaf, Marcel G. W.; van Eijck, Casper H.; Festen, Sebastiaan; Gerhards, Michael F.; Groot Koerkamp, Bas; Hagendoorn, Jeroen; van der Harst, Erwin; de Hingh, Ignace H.; Dejong, Cees H.; Kazemier, Geert; Klaase, Joost M.; de Kleine, Ruben H J; van Laarhoven, Cornelis J.; Lips, Daan J.; Luyer, Misha Dp; Molenaar, I Quintus; Nieuwenhuijs, Vincent B.; Patijn, Gijs A.; Roos, Daphne; Scheepers, Joris Jg; Van Der Schelling, George P.; Steenvoorde, Pascal; Swijnenburg, Rutger-Jan; Wijsman, Jan H; Abu Hilal, Moh'd; Busch, Olivier R C; Besselink, Marc G H; Dutch Pancreatic Cancer Group (BioMed Central, 2017-04-08)
    BACKGROUND: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less ...
  • Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer 
    Heerma Van Voss, Marise R.; Vesuna, Farhad; Bol, Guus M.; Meeldijk, Jan; Raman, Ana; Offerhaus, G. Johan; Buerger, Horst; Patel, Arvind H.; Van Der Wall, Elsken; Van Diest, Paul J.; Raman, Venu (Dove Medical Press Ltd, 2017-07-17)
    Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear ...
  • Small steps beyond benchmarking 
    De Lange, Dylan W.; Dongelmans, Dave A.; de Keizer, Nicolette F. (Associacao de Medicina Intensiva Brasileira - AMIB, 2017-04-01)
  • Is a Single Initial Procalcitonin Test Sufficient in Septic, Critically Ill Patients to Minimize Antibiotic Use? 
    van Oers, Jos A H; de Jong, Evelien; Beishuizen, Albertus B; Nijsten, Maarten W N; Girbes, Armand R.; de Lange, Dylan W (Elsevier, 2017-07)
  • Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients 
    Eisenga, Michele F.; Minovic, Isidor; Berger, Stefan P; Kootstra-Ros, Jenny E.; van den Berg, Else; Riphagen, Ineke J.; Navis, Gerjan J.; Van der Meer, Peter; Bakker, Stephan J. L.; Gaillard, Carlo A. J. M. (Wiley-Blackwell, 2016-11)
    Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to ...
  • Distinct in vitro Complement Activation by Various Intravenous Iron Preparations 
    Hempel, Julia Cordelia; Poppelaars, Felix; da Costa, Mariana Gaya; Franssen, Casper F. M.; de Vlaam, Thomas P G; Daha, Mohamed R.; Berger, Stefan P; Seelen, Marc A. J.; Gaillard, Carlo A. J. M. (S. Karger AG, 2017)
    Background: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the ...
  • Urinary potassium excretion, renal ammoniagenesis, and risk of graft failure and mortality in renal transplant recipients 
    Eisenga, Michele F.; Kieneker, Lyanne M.; Soedamah-Muthu, Sabita S.; van den Berg, Else; Deetman, Petronella E.; Navis, Gerjan J.; Gans, Reinold O. B.; Gaillard, Carlo A. J. M.; Bakker, Stephan J. L.; Joosten, Michel M. (Elsevier, 2016-12)
    Background: Renal transplant recipients (RTRs) have commonly been urged to limit their potassium intake during renal insufficiency and may adhere to this principle after transplantation. Importantly, in experimental animal ...
  • Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment 
    Zittema, Debbie; Casteleijn, Niek F.; Bakker, Stephan J. L.; Boesten, Lianne S M; Duit, A A Margreeth; Franssen, Casper F. M.; Gaillard, Carlo A. J. M.; Gansevoort, Ron T. (Public Library of Science, 2017-01-12)
    BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients have an impaired urine concentrating capacity. Increased circulating vasopressin (AVP) concentrations are supposed to play a role in the progression ...
  • Safety of intravenous ferric carboxymaltose versus oral iron in patients with nondialysis-dependent CKD 
    Roger, Simon D; Gaillard, Carlo A; Bock, Andreas H; Carrera, Fernando; Eckardt, Kai-Uwe; Van Wyck, David B; Cronin, Maureen; Meier, Yvonne; Larroque, Sylvain; Macdougall, Iain C (Oxford University Press, 2017-02-27)
    Background: The evidence base regarding the safety of intravenous (IV) iron therapy in patients with chronic kidney disease (CKD) is incomplete and largely based on small studies of relatively short duration.Methods: ...
  • High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients 
    Eisenga, Michele F; Zelle, Dorien M; Sloan, John H; Gaillard, Carlo A J M; Bakker, Stephan J. L.; Dullaart, Robin P F (American Diabetes Association Inc., 2017-05-01)
    Objective: New-onset diabetes after transplantation (NODAT) is a major complication in renal transplant recipients (RTRs). Cholesterol metabolism has been linked to diabetes development. Proprotein convertase subtilisin/kexin ...
  • Urinary Prednisolone Excretion is a Determinant of Serum Hepcidin Levels in Renal Transplant Recipients 
    Eisenga, Michele F; Dullaart, Robin P F; Berger, Stefan P; Touw, Daan J; Bakker, Stephan J. L.; Gaillard, Carlo A J M (John Wiley & Sons Inc., 2017-05-05)
  • Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients 
    Sotomayor, C. G.; Eisenga, Michele F; Neto, Antonio W Gomes; Ozyilmaz, Akin; Gans, Rijk O B; Jong, Wilhelmina H A de; Zelle, Dorien M; Berger, Stefan P; Gaillard, Carlo A J M; Navis, Gerjan J.; Bakker, Stephan J. L. (Multidisciplinary Digital Publishing Institute (MDPI), 2017-06-02)
    Vitamin C may reduce inflammation and is inversely associated with mortality in the general population. We investigated the association of plasma vitamin C with all-cause mortality in renal transplant recipients (RTR); and ...