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Now showing items 29181-29200 of 40729

Renal function in patients with non-dialysis chronic kidney disease receiving intravenous ferric carboxymaltose

Macdougall, Iain C.; Bock, Andreas H.; Carrera, Fernando; Eckardt, Kai-Uwe; Gaillard, Carlo; Van Wyck, David; Meier, Yvonne; Larroque, Sylvain; Roger, Simon D.; Investigators, FIND-CKD Study (BioMed Central, 2017-01-17)

Background: Preclinical studies demonstrate renal proximal tubular injury after administration of some intravenous iron preparations but clinical data on renal effects of intravenous iron are sparse.Methods: FIND-CKD was ...
Letter by Scholtens et al Regarding Article, "Characterization of 18F-Fluorodeoxyglucose Uptake Patterns in Noninfected Prosthetic Heart Valves"

Scholtens, Asbjørn M.; Lam, Marnix G E H; Verberne, Hein J (Lippincott Williams & Wilkins, 2017-07)
Long-Term Follow-up of the PADI Trial: Percutaneous Transluminal Angioplasty Versus Drug-Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia

Spreen, Marlon I; Martens, Jasper M; Knippenberg, Bob; van Dijk, Lukas C; De Vries, Jean-Paul P. M.; Vos, Jan Albert; de Borst, Gert Jan; Vonken, Evert-Jan P A; Bijlstra, Okker D; Wever, Jan J; Statius van Eps, Randolph G; Mali, Willem P Th M; van Overhagen, Hendrik (Wiley-Blackwell, 2017-04-14)

BACKGROUND: Clinical outcomes reported after treatment of infrapopliteal lesions with drug-eluting stents (DESs) have been more favorable compared with percutaneous transluminal angioplasty with a bailout bare metal stent ...
Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation

Massafra, Vittoria; Milona, Alexandra; Vos, Harmjan R.; Burgering, Boudewijn M T; Van Mil, Saskia W C (Public Library of Science, 2017-02-01)

Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and signals to the liver, where it contributes to the homeostasis ...
Identification of discrete vascular lesions in the extremities using post-mortem computed tomography angiography – Case reports

Haakma, Wieke; Rohde, Marianne; Uhrenholt, Lars; Pedersen, Michael; Boel, Lene Warner Thorup (Elsevier, 2017-06-01)

In this case report, we introduced post-mortem computed tomography angiography (PMCTA) in three cases suffering from vascular lesions in the upper extremities. In each subject, the third part of the axillary arteries and ...
Wounding induces dedifferentiation of epidermal Gata6 + cells and acquisition of stem cell properties

Donati, Giacomo; Rognoni, Emanuel; Hiratsuka, Toru; Liakath-Ali, Kifayathullah; Hoste, Esther; Kar, Gozde; Kayikci, Melis; Russell, Roslin; Kretzschmar, Kai; Mulder, Klaas W.; Teichmann, Sarah A.; Watt, Fiona M. (Nature Research, 2017-05-31)

The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the ...
SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells

Morcos, Mina N.F.; Schoedel, Kristina B.; Hoppe, Anja; Behrendt, Rayk; Basak, Onur; Clevers, Hans C.; Roers, Axel; Gerbaulet, Alexander (Cell Press, 2017-06-06)

Blood cell generation depends on continuous cellular output by the sequential hierarchy of hematopoietic stem cell (HSC) and progenitor populations that all contain quiescent and actively cycling cells. Hematopoietic stem ...
Quality assurance and the need to evaluate interventions and audit programme outcomes

Zhao, Min; Vaartjes, Ilonca; Klipstein-Grobusch, Kerstin; Kotseva, Kornelia; Jennings, Catriona; Grobbee, Diederick E; Graham, Ian (Oxford University Press, 2017-06)

Evidence-based clinical guidelines provide standards for the provision of healthcare. However, these guidelines have been poorly implemented in daily practice. Clinical audit is a quality improvement tool to promote quality ...
Coordination of cell cycle progression and mitotic spindle assembly involves histone H3 lysine 4 methylation by set1/COMPASS

Beilharz, Traude H.; Harrison, Paul F.; Miles, Douglas Maya; See, Michael Ming; Le, Uyen Minh Merry; Kalanon, Ming; Curtis, Melissa Jane; Hasan, Qambar; Saksouk, Julie; Margaritis, Thanasis; Holstege, Frank; Geli, Vincent; Dichtl, Bernhard (Oxford University Press, 2017-01-01)

Methylation of histone H3 lysine 4 (H3K4) by Set1 complex/COMPASS is a hallmark of eukaryotic chromatin, but it remains poorly understood how this post-translational modification contributes to the regulation of biological ...
Effectiviteit van Triple P in Nederland: stand van zaken en controverse

Schappin, R; de Graaf, Ireen; Reijneveld, S.A. (Bohn Stafleu van Loghum, 2017-06)

Objective: The Triple P – Positive Parenting Program is available in over 50% of the Dutch municipalities. In this article we summarize the effects of Triple P as found in international meta-analyses and Dutch research. ...
Tumor-specific uptake of fluorescent bevacizumab-IRDye800CW microdosing in patients with primary breast cancer: a phase I feasibility study

Lamberts, Laetitia E; Koch, Maximillian; de Jong, Johannes S; Adams, Arthur; Glatz, Juergen; Kranendonk, Marriette E G; Terwisscha van Scheltinga, Anton G T; Jansen, Liesbeth; de Vries, Jakob; Lub-de Hooge, Marjolijn N; Schroder, Carolien P; Jorritsma-Smit, Annelies; Linssen, Matthijs D; de Boer, Esther; van der Vegt, Bert; Nagengast, Wouter B; Elias, Sjoerd G; Oliveira, Sabrina; Witkamp, Arjen; Mali, Willem P Th M; van der Wall, Elsken; Van Diest, Paul J; de Vries, Elisabeth G; Ntziachristos, Vasilis; van Dam, Gooitzen M (American Association for Cancer Research Inc., 2017-06)

Purpose: To provide proof of principle of safety, breast tumor-specific uptake, and positive tumor margin assessment of the systemically administered near-infrared fluorescent tracer bevacizumab-IRDye800CWtargeting VEGF-A ...
Effect modification in the association between glycated haemoglobin and cardiovascular disease and mortality in patients with type 2 diabetes

van Munster, Sanne N; van der Graaf, Yolanda; de Valk, Harold W; Visseren, Frank L J; Westerink, Jan; SMART Study Group (Wiley-Blackwell, 2017-03)

AIM: To identify patients with type 2 diabetes (T2D) who may benefit from lower or higher glycated haemoglobin (HbA1c) targets, based on readily available patient characteristics. MATERIALS AND METHODS: Patients with T2D ...
QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot

Bokma, Jouke P; Winter, Michiel M; Vehmeijer, Jim T; Vliegen, Hubert W; van Dijk, Arie Pj; van Melle, Joost P; Meijboom, Folkert J.; Post, Martijn C; Zwinderman, Aeilko H; Mulder, Barbara J M; Bouma, Berto J. (BMJ Publishing Group, 2016-11-01)

Background Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented QRS complexes, a simple measurement on ECG, are related to ...
Respiratory syncytial virus hospitalization and mortality: Systematic review and meta-analysis

Stein, Renato T; Bont, Louis J.; Zar, Heather; Polack, Fernando P.; Park, Caroline; Claxton, Ami; Borok, Gerald; Butylkova, Yekaterina; Wegzyn, Colleen (John Wiley & Sons Inc., 2017-04-01)

BACKGROUND: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. METHODS: Systematic ...
Choosing outcome assessment tools in haemophilia care and research: A multidisciplinary perspective

Fischer, K.; Poonnoose, P.; Dunn, A. L.; Babyn, P.; Manco-Johnson, M. J.; David, J. A.; van der Net, J.; Feldman, B.; Berger, K.; Carcao, M.; de Kleijn, P.; Silva, M.; Hilliard, P.; Doria, A.; Srivastava, A.; Blanchette, V. (Wiley-Blackwell, 2017-01)

Introduction: The implementation of early long-term, regular clotting factor concentrate (CFC) replacement therapy ('prophylaxis') has made it possible to offer boys with haemophilia a near normal life. Many different ...
Histological characteristics of diffuse idiopathic skeletal hyperostosis

Kuperus, JS; Westerveld, L Anneloes; Rutges, Joost A; Alblas, Jacqueline; van Rijen, Mattie H; Bleys, Ronald L A W; Oner, F Cumhur; Verlaan, JJ (John Wiley & Sons Inc., 2017-01)

Diffuse idiopathic skeletal hyperostosis (DISH) is a predominantly radiographic diagnosis and histological knowledge of DISH is limited. The aim of this study was to describe the histological characteristics of DISH in the ...
Non-adherence to the rule of 3 does not increase the risk of adverse events in esophageal dilation

Grooteman, Karina V; Wong Kee Song, Louis M; Vleggaar, Frank P.; Siersema, Peter D.; Baron, Todd H (Mosby Inc., 2017-02-01)

Background and Aims Although the rule of 3 is recommended to minimize the risk of perforation when esophageal dilation is performed using bougie dilators, there are no data to validate its use. Our aim was to investigate ...
Diffusion-weighted MRI in paediatric oncology: lymphoma and nephroblastoma

Littooij, A.S. (Utrecht University, 2017-09-14)

The aim of this thesis was to assess the value of MRI including DWI in paediatric lymphoma and nephroblastoma. Part I - lymphoma The use of FDG-PET/CT in staging paediatric lymphoma is generally incorporated into current ...
Molecular and cellular profiling of systemic sclerosis and its preclinical stages

Cossu, Marta (Utrecht University, 2017-09-07)

The development of unrestrained fibrosis in the skin and internal organs is the hallmark of systemic sclerosis (SSc). Nevertheless, it is known that fibrosis is preceded by vascular and immune modifications. On the basis ...
Treatment and treatment restrictions in patients with acute ischaemic stroke

Geurts, M. (Utrecht University, 2017-09-19)

Acute stroke is often a devastating condition. Despite the current treatment strategies, about half of patients has a poor functional outcome. New treatments strategies are clearly needed. Therapeutic hypothermia, the ...

Now showing items 29181-29200 of 40729