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Now showing items 29141-29160 of 40729

Soft tissue lesions

Flucke, Uta; Slootweg, Pieter J. (Springer Verlag Berlin, 2017-01-01)

This chapter covers the broad spectrum of soft tissue lesions occurring in the head and neck, based on the current WHO classification. Most of these lesions are very rare, and there are a lot of overlapping features that ...
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: Analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data

Mynarek, Martin; Pizer, Barry; Dufour, Christelle; van Vuurden, Dannis G; Garami, Miklos; Massimino, Maura; Fangusaro, Jason; Davidson, Tom; Gil-Da-Costa, Maria Joao; Sterba, Jaroslav; Benesch, Martin; Gerber, Nicolas; Juhnke, B. Ole; Kwiecien, Robert; Pietsch, Torsten; Kool, Marcel; Clifford, Steve; Ellison, David W.; Giangaspero, Felice; Wesseling, Pieter; Gilles, Floyd; Gottardo, Nicholas; Finlay, Jonathan L.; Rutkowski, Stefan; Von Hoff, Katja (Oxford University Press, 2017-04-01)

Background. Pineoblastoma is a rare pineal region brain tumor. Treatment strategies have reflected those for other malignant embryonal brain tumors. Patients and Methods. Original prospective treatment and outcome data ...
Hypoxia-Mediated Mechanisms Associated with Antiangiogenic Treatment Resistance in Glioblastomas

Mahase, Sean; Rattenni, Rachel N.; Wesseling, Pieter; Leenders, William P J; Baldotto, Clarissa; Jain, Rajan; Zagzag, David (Elsevier, 2017-05-01)

Glioblastomas (GBMs) are malignant tumors characterized by their vascularity and invasive capabilities. Antiangiogenic therapy (AAT) is a treatment option that targets GBM-associated vasculature to mitigate the growth of ...
Impact of MR-guided boiling histotripsy in distinct murine tumor models

Hoogenboom, Martijn; Eikelenboom, Dylan C.; van den Bijgaart, Renske J E; Heerschap, Arend; Wesseling, Pieter; den Brok, Martijn H; Fütterer, Jurgen J.; Adema, Gosse J (Elsevier, 2017-09-01)

Interest in mechanical high intensity focused ultrasound (HIFU) ablation is rapidly growing. Boiling histotripsy (BH) is applied for mechanical fragmentation of soft tissue into submicron fragments with limited temperature ...
Dedifferentiated Liposarcoma of the Retroperitoneum with Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology

Van Haverbeke, Carole; Van Dorpe, Jo; Lecoutere, Evelyne; Flucke, Uta; Ferdinande, Liesbeth; Creytens, David (SAGE Publications Inc., 2017)

A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological ...
Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors

Droog, Marjolein; Nevedomskaya, Ekaterina; Dackus, Gwen M.; Fles, Renske; Kim, Yongsoo; Hollema, Harry; Mourits, Marian J; Nederlof, Petra M.; Van Boven, Hester H.; Linn, Sabine C.; van Leeuwen, Flora E.; Wessels, Lodewyk F A; Zwart, Wilbert (National Academy of Sciences, 2017-02-21)

The DNA-binding sites of estrogen receptor α (ERα) show great plasticity under the control of hormones and endocrine therapy. Tamoxifen is a widely applied therapy in breast cancer that affects ERα interactions with ...
Trastuzumab in combination with weekly paclitaxel and carboplatin as neo-adjuvant treatment for HER2-positive breast cancer: The TRAIN-study

van Ramshorst, Mette S.; van Werkhoven, Erik; Mandjes, Ingrid A.M.; Schot, Margaret; Wesseling, Jelle; Vrancken Peeters, Marie Jeanne T.F.D.; Meerum Terwogt, Jetske M.; Bos, Monique M E M; Oosterkamp, Hendrika M; Rodenhuis, Sjoerd; Linn, Sabine C.; Sonke, Gabe S (Elsevier Limited, 2017-03-01)

Aim To determine the efficacy and safety of an anthracycline-free neo-adjuvant regimen consisting of weekly paclitaxel, carboplatin and trastuzumab in HER2-positive breast cancer. Patients and methods Patients with stage ...
Accuracy of the online prognostication tools PREDICT and Adjuvant! for early-stage breast cancer patients younger than 50 years

Engelhardt, Ellen G.; van den Broek, Alexandra J.; Linn, Sabine C.; Wishart, Gordon C.; Rutgers, Emiel J. Th.; van de Velde, Anthonie O.; Smit, Vincent T.H.B.M.; Voogd, Adri C.; Siesling, Sabine; Brinkhuis, Mariël; Seynaeve, Caroline; Westenend, Pieter J.; Stiggelbout, Anne M; Tollenaar, Rob A E M; van Leeuwen, Flora E.; van 't Veer, Laura J; Ravdin, Peter M.; Pharaoh, Paul D.P.; Schmidt, Marjanka K. (Elsevier Limited, 2017-06-01)

Importance Online prognostication tools such as PREDICT and Adjuvant! are increasingly used in clinical practice by oncologists to inform patients and guide treatment decisions about adjuvant systemic therapy. However, ...
The Height-Width-Depth Ratios of the Intervertebral Discs and Vertebral Bodies in Adolescent Idiopathic Scoliosis vs Controls in a Chinese Population

Chen, Hao; Schlösser, Tom P.C.; Brink, Rob C.; Colo, DIno; Van Stralen, Marijn; Shi, Lin; Chu, Winnie C W; Heng, Pheng-Ann; Castelein, RM; Cheng, Jack C Y (Nature Publishing Group, 2017-04-18)

Adolescent idiopathic scoliosis (AIS) patients have been reported to be taller and more slender than normal controls, suggesting less mechanical stiffness of their trunk and spine. For assessment of mechanical stiffness, ...
BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers

Vos, Shoko; Moelans, Cathy Beatrice; van Diest, Paul Joannes (BioMed Central Ltd., 2017-05-31)

Background: In breast cancer, BRCA promoter hypermethylation and BRCA germline mutations are said to occur together rarely, but this property has not yet been translated into a clinical test. Our aim in this study was to ...
Molecular diagnostics in breast cancer routine practice

ter Hoeve, Natalie D.; Moelans, Cathy B.; Schrijver, Willemijne A.M.E.; de Leng, Wendy; van Diest, Paul J. (Touch Briefings, 2017)

The portfolio of adjuvant systemic treatment of breast cancer nowadays contains novel anti-hormonal and chemotherapeutic drugs, immunotherapeutic approaches and small molecules that are only effective in a limited number ...
Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer

Heerma van Voss, Marise R.; Brilliant, Justin D.; Vesuna, Farhad; Bol, Guus M.; van der Wall, Elsken; van Diest, Paul J.; Raman, Venu (Humana Press, 2017-03-01)

Triple-negative breast cancers have unfavorable outcomes due to their inherent aggressive behavior and lack of targeted therapies. Breast cancers occurring in BRCA1 mutation carriers are mostly triple-negative and harbor ...
Male breast cancer precursor lesions: Analysis of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program

Doebar, Shusma C.; Slaets, Leen; Cardoso, Fatima; Giordano, Sharon H.; Bartlett, John M.S.; Tryfonidis, Konstantinos; Dijkstra, Nizet H.; Schröder, Caroline P.; van Asperen, Christi J.; Linderholm, Barbro; Benstead, Kim; Dinjens, Winan N.M.; van Marion, Ronald; Van Diest, Paul J.; Martens, John W. M.; van Deurzen, Carolien H M (Elsevier, 2017-04-01)

In men, data regarding breast cancer carcinogenesis are limited. The aim of our study was to describe the presence of precursor lesions adjacent to invasive male breast cancer, in order to increase our understanding of ...
Site-specific gene expression patterns in oral cancer

Frohwitter, Gesche; Buerger, Horst; Korsching, Eberhard; van Diest, Paul J.; Kleinheinz, Johannes; Fillies, Thomas (BioMed Central Ltd., 2017-05-10)

Background: Squamous cell carcinomas (SCCs) are the most prevalent malignant tumours within the head and neck. Evidence exists that distinct genes are differentially regulated in SCCs of the oral cavity compared to other ...
Changes in Brain Structural Networks and Cognitive Functions in Testicular Cancer Patients Receiving Cisplatin-Based Chemotherapy

Amidi, Ali; Hosseini, S. M.Hadi; Leemans, Alexander; Kesler, Shelli R.; Agerbæk, Mads; Wu, Lisa M.; Zachariae, Robert (Oxford University Press, 2017-12-01)

Background: Cisplatin-based chemotherapy may have neurotoxic effects within the central nervous system. The aims of this study were 1) to longitudinally investigate the impact of cisplatin-based chemotherapy on whole-brain ...
Increased survival means increasing roles for primary care after cancer diagnosis

Adam, Rosalind; de Wit, Niek; Groome, Patti; Helsper, Charles W; McBride, Mary; Watson, Eila; Wind, Jan (Royal College of General Practitioners, 2017-08)
Estimated Prevalence of the Target Population for Brain-Computer Interface Neurotechnology in the Netherlands

Pels, Elmar G M; Aarnoutse, Erik J; Ramsey, Nick F; Vansteensel, Mariska J. (SAGE Publications Inc., 2017-06-29)

BACKGROUND: People who suffer from paralysis have difficulties participating in society. Particularly burdensome is the locked-in syndrome (LIS). LIS patients are not able to move and speak but are cognitively healthy. ...
The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review

Harmsen, Marissa J; Browne, Joyce L; Venter, Francois; Klipstein-Grobusch, Kerstin; Rijken, Marcus J (BioMed Central, 2017-07-11)

BACKGROUND: Observed adverse effects of antiretroviral therapy (ART) on the lipid profile could be of significance in pregnancy. This systematic review aims to summarize studies that investigated the association between ...
Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats

Boekhoudt, Linde; Voets, Elisa S; Flores-Dourojeanni, Jacques P; Luijendijk-Berg, Mieneke Cm; Vanderschuren, Louk Jmj; Adan, Roger Ah (Springer Nature, 2017-05-01)

Attentional impairments and exaggerated impulsivity are key features of psychiatric disorders, such as attention-deficit/hyperactivity disorder, schizophrenia, and addiction. These deficits in attentional performance and ...
Final screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval

Yousaf-Khan, Uraujh; van der Aalst, Carlijn; de Jong, Pim A; Heuvelmans, Marjolein; Scholten, Ernst; Lammers, Jan-Willem; van Ooijen, Peter; Nackaerts, Kristiaan; Weenink, Carla; Groen, Harry; Vliegenthart, Rozemarijn; Ten Haaf, Kevin; Oudkerk, Matthijs; de Koning, Harry (BMJ Publishing Group, 2017-06)

Background In the USA annual lung cancer screening is recommended. However, the optimal screening strategy (eg, screening interval, screening rounds) is unknown. This study provides results of the fourth screening round ...

Now showing items 29141-29160 of 40729