Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment

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Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment
 
Zittema, Debbie; Casteleijn, Niek F.; Bakker, Stephan J. L.; Boesten, Lianne S M; Duit, A A Margreeth; Franssen, Casper F. M.; Gaillard, Carlo A. J. M.; Gansevoort, Ron T.
(2017) PLoS ONE [E], volume 12, issue 1
(Article)
Abstract
BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients have an impaired urine concentrating capacity. Increased circulating vasopressin (AVP) concentrations are supposed to play a role in the progression of ADPKD. We hypothesized that ADPKD patients have a more severely impaired urine concentrating capacity in comparison to other patients with chronic ... read more
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Keywords: ANTAGONISTS, CYSTIC-DISEASE, DEFECTS, OSMOREGULATION, PLASMA COPEPTIN, POLYCYSTIC KIDNEY-DISEASE, UREA, Journal Article, Clinical Trial
DOI: https://doi.org/10.1371/journal.pone.0169263
ISSN: 1932-6203
Publisher: Public Library of Science
Note: Publisher Copyright: © 2017 Zittema et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
(Peer reviewed)