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UMC Repository: Recent submissions

  • Sensory expectation, perception, and autonomic nervous system responses to package colours and product popularity 
    Schulte-Holierhoek, Aurelia; Verastegui-Tena, Luz; Goedegebure, Robert P.G.; Piqueras Fiszman, Betina; Smeets, Paul A.M. (Elsevier Limited, 2017-12-01)
    Consumers’ perception of, and behaviour towards, products are influenced by extrinsic cues, including packaging and social norms. However, the understanding of this process is unsatisfactorily captured by questionnaires. ...
  • Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome 
    Collins, Ryan L; Brand, Harrison; Redin, Claire E.; Hanscom, Carrie; Antolik, Caroline; Stone, Matthew R; Glessner, Joseph T.; Mason, Tamara; Pregno, Giulia; Dorrani, Naghmeh; Mandrile, Giorgia; Giachino, Daniela; Perrin, Danielle; Walsh, Cole; Cipicchio, Michelle; Costello, Maura; Stortchevoi, Alexei; An, Joon Yong; Currall, Benjamin B; Seabra, Catarina M; Ragavendran, Ashok; Margolin, Lauren; Martinez-Agosto, Julian A.; Lucente, Diane; Levy, Brynn; Sanders, Jan-Stephan; Wapner, Ronald J.; Quintero-Rivera, Fabiola; Kloosterman, Wigard; Talkowski, Michael E. (BioMed Central, 2017-03-06)
    Background: Structural variation (SV) influences genome organization and contributes to human disease. However, the complete mutational spectrum of SV has not been routinely captured in disease association studies. Results: ...
  • Mobility assessment of a rural population in the Netherlands using GPS measurements 
    Klous, Gijs; Smit, Lidwien A M; Borlée, Floor; Coutinho, Roel A; Kretzschmar, Mirjam E E; Heederik, Dick J J; Huss, Anke (BioMed Central Ltd., 2017-08-09)
    BACKGROUND: The home address is a common spatial proxy for exposure assessment in epidemiological studies but mobility may introduce exposure misclassification. Mobility can be assessed using self-reports or objectively ...
  • Microbubbles-Assisted Ultrasound Triggers the Release of Extracellular Vesicles 
    Yuana, Yuana; Jiang, Linglei; Lammertink, Bart H A; Vader, Pieter; Deckers, Roel; Bos, Clemens; Schiffelers, Raymond M; Moonen, Chrit T (Multidisciplinary Digital Publishing Institute (MDPI), 2017-08)
    Microbubbles-assisted ultrasound (USMB) has shown promise in improving local drug delivery. The formation of transient membrane pores and endocytosis are reported to be enhanced by USMB, and they contribute to cellular ...
  • Lamin A/C-Related Cardiac Disease: Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation 
    Hoorntje, Edgar T; Bollen, Ilse Ae; Barge-Schaapveld, Daniela Q; Van Tienen, Florence H J; Te Meerman, Gerard J; Jansweijer, Joeri A; van Essen, Anthonie J; Volders, Paul G. A.; Constantinescu, Alina; Van Den Akker, Peter C.; van Spaendonck-Zwarts, Karin Y.; Oldenburg, Rogier A; Marcelis, Carlo L. M.; van der Smagt, Jasper J; Hennekam, Eric A; Vink, Aryan; Bootsma, Marianne; Aten, Emmelien; Wilde, Arthur A A M; van den Wijngaard, Arthur; Broers, Jos L; Jongbloed, Jan D. H.; van der Velden, Jolanda; van den Berg, Maarten P.; van Tintelen, J. Peter (Lippincott Williams & Wilkins, 2017-08)
    Interpretation of missense variants can be especially difficult when the variant is also found in control populations. This is what we encountered for the LMNA c.992G>A (p.(Arg331Gln)) variant. Therefore, to evaluate the ...
  • Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers 
    Echalier, C.; Levato, R.; Mateos-Timoneda, Miguel A; Castaño, O.; Déjean, S.; Garric, X.; Pinese, C.; Noël, D.; Engel, E.; Martinez, J.; Mehdi, A.; Subra, G. (Springer, 2017)
    An unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol-gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ...
  • Polylactic acid organogel as versatile scaffolding technique 
    Punet, Xavier; Levato, Riccardo; Bataille, Isabelle; Letourneur, Didier; Engel, Elisabeth; Mateos-Timoneda, Miguel A (Elsevier, 2017-03-24)
    Tissue engineering requires scaffolding techniques based on non-toxic processes that permits the fabrication of constructs with tailored properties. Here, a two-step methodology based on the gelation and precipitation of ...
  • Layer-by-layer bioassembly of cellularized polylactic acid porous membranes for bone tissue engineering 
    Guduric, Vera; Metz, Carole; Siadous, Robin; Bareille, Reine; Levato, Riccardo; Engel, Elisabeth; Fricain, Jean-Christophe; Devillard, Raphaël; Luzanin, Ognjan; Catros, Sylvain (Springer Netherlands, 2017)
    Abstract: The conventional tissue engineering is based on seeding of macroporous scaffold on its surface (“top–down” approach). The main limitation is poor cell viability in the middle of the scaffold due to poor diffusion ...
  • Impact of Survey Administration Mode on the Results of a Health-Related Discrete Choice Experiment: Online and Paper Comparison 
    Determann, Domino; Lambooij, Mattijs S.; Steyerberg, Ewout W.; de Bekker-Grob, Esther W; de Wit, G Ardine (Elsevier Limited, 2017-07-18)
    BACKGROUND: Electronic data collection is increasingly being used for discrete choice experiments (DCEs). OBJECTIVES: To study whether paper or electronic administration results in measurement effects. METHODS: Respondents ...
  • Henry Beecher en de medische wetenschap: De vijftigste verjaardag van een roemrucht artikel 
    Jacobs, N; Huisman, F G (Bohn Stafleu van Loghum, 2017)
    In 2016, it had been exactly half a century ago that Henry Beecher published his article 'Ethics and clinical research' in The New England Journal of Medicine. Today, this article is considered a turning point in the history ...
  • The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommendations for daily practice 
    van Vugt, Lieke J.; van der Vleuten, Carine J.M.; Flucke, Uta; Blokx, Willeke A M (Elsevier, 2017-06)
    OBJECTIVE: To assess the utility of GLUT1 as an immunohistochemical marker in the diagnostics of cutaneous vascular anomalies. METHODS: A systematic literature search was conducted for studies on GLUT1 staining patterns ...
  • TFG-MET fusion in an infantile spindle cell sarcoma with neural features 
    Flucke, Uta; van Noesel, Max M.; Wijnen, Marc; Zhang, Lei; Chen, Chun Liang; Sung, Yun Shao; Antonescu, Cristina R. (Wiley-Liss Inc., 2017-09-01)
    An increasing number of congenital and infantile sarcomas displaying a primitive, monomorphic spindle cell phenotype have been characterized to harbor recurrent gene fusions, including infantile fibrosarcoma and congenital ...
  • Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults 
    Boon, Eline; van der Graaf, Winette T A; Gelderblom, Hans; Tesselaar, Margot E T; van Es, Robert J.J.; Oosting, Sjoukje F; de Bree, Remco; van Meerten, Esther; Hoeben, Ann; Smeele, Ludi E.; Willems, Stefan M.; Witjes, Max J H; Buter, Jan; Baatenburg de Jong, Robert J; Flucke, Uta E.; Peer, Petronella G.M.; Bovée, Judith V.M.G.; Van Herpen, Carla M L (John Wiley & Sons Inc., 2017-01-01)
    Background: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck. Methods: All records of patients older than 16 years diagnosed with ...
  • ABVD or BEACOPPbaseline along with involved-field radiotherapy in early-stage Hodgkin Lymphoma with risk factors: Results of the European Organisation for Research and Treatment of Cancer (EORTC)–Groupe d'Étude des Lymphomes de l'Adulte (GELA) H9-U intergroup randomised trial 
    Fermé, Christophe; Thomas, José; Brice, Pauline; Casasnovas, Olivier; Vranovsky, Andrej; Bologna, Serge; Lugtenburg, Pieternella J; Bouabdallah, Réda; Carde, Patrice; Sebban, Catherine; Eghbali, Houchingue; Salles, Gilles; Van Imhoff, Gustaaf W.; Thyss, Antoine; Noordijk, Evert M.; Reman, Oumédaly; Lybeert, Marnix L.M.; Janvier, Maud; Spina, Michele; Audhuy, Bruno; Raemaekers, John M M; Delarue, Richard; Anglaret, Bruno; de Weerdt, Okke; Marjanovic, Zora; Tersteeg, Robbert J.H.A.; de Jong, Daphne; Brière, Josette; Henry-Amar, Michel; for the European Organisation for Research and Treatment of Cancer Lymphoma Group, and; the Groupe d'Étude des Lymphomes de l'Adulte (Elsevier Limited, 2017-08-01)
    Purpose For early-stage Hodgkin lymphoma (HL), optimal chemotherapy regimen and the number of cycles to be delivered remain to settle down. The H9-U trial compared three modalities of chemotherapy followed by involved-field ...
  • Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma 
    Sewing, A. Charlotte P; Lagerweij, Tonny; van Vuurden, Dannis G; Meel, Michaël H.; Veringa, Susanna J E; Carcaboso, Angel M.; Gaillard, Pieter J.; Peter Vandertop, W.; Wesseling, Pieter; Noske, David P.; Kaspers, Gertjan J.L.; Hulleman, Esther (American Association of Neurological Surgeons, 2017-05-01)
    OBJECTIVE Pediatric high-grade gliomas (pHGGs) including diffuse intrinsic pontine gliomas (DIPGs) are primary brain tumors with high mortality and morbidity. Because of their poor brain penetrance, systemic chemotherapy ...
  • 3D whole-heart myocardial tissue analysis 
    van den Broek, HT; de Jong, Leon; Doevendans, Pieter A.; Chamuleau, Steven A.J.; van Slochteren, Frebus J.; Van Es, René (MYJoVE Corporation, 2017-04-12)
    Cardiac regenerative therapies aim to protect and repair the injured heart in patients with ischemic heart disease. By injecting stem cells or other biologicals that enhance angio- or vasculogenesis into the infarct border ...
  • The cost of Lyme borreliosis 
    van den Wijngaard, Cees C; Hofhuis, Agnetha; Wong, Albert; Harms, Margriet G; de Wit, G Ardine; Lugnér, Anna K; Suijkerbuijk, Anita W M; Mangen, Marie-Josée J; van Pelt, Wilfrid (Oxford University Press, 2017)
    Background: Lyme borreliosis (LB) is the most frequently reported tick-borne infection in Europe and North America. The aim of this study was to estimate the cost-of-illness of LB in the Netherlands. Methods: We used ...
  • Moderate alcohol consumption is associated with lower chronic disease burden expressed in disability-adjusted life years: a prospective cohort study 
    Beulens, Joline W J; Fransen, Heidi P; Struijk, Ellen A; Boer, Jolanda M A; de Wit, G Ardine; Onland-Moret, N Charlotte; Hoekstra, Jeljer; Bueno-de-Mesquita, H Bas; Peeters, Petra H M; May, Anne M (Springer Netherlands, 2017)
    The relation of alcohol consumption with disease burden remains debated partly due to opposite associations with cardiovascular disease (CVD) and cancer. The relation of alcohol consumption with disease burden expressed ...
  • Individual patient information to select patients for different radiation techniques 
    Quik, E. H.; Feenstra, T. L.; Postmus, D.; Slotman, B. J.; Leemans, C. R.; Krabbe, P. F M; Langendijk, J. A. (Elsevier Limited, 2016-07)
    BACKGROUND AND PURPOSE: Proton therapy is an emerging technique in radiotherapy which results in less dose to the normal tissues with similar target dose than photon therapy, the current standard. Patient-level simulation ...
  • Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma 
    Van Lith, Sanne A M; Navis, Anna C.; Lenting, Krissie; Verrijp, Kiek; Schepens, Jan T G; Hendriks, Wiljan J A J; Schubert, Nil A.; Venselaar, Hanka; Wevers, Ron A.; Van Rooij, Arno; Wesseling, Pieter; Molenaar, Remco J.; Van Noorden, Cornelis J F; Pusch, Stefan; Tops, Bastiaan; Leenders, William P J (Nature Publishing Group, 2016-07-27)
    The majority of low-grade and secondary high-grade gliomas carry heterozygous hotspot mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or the mitochondrial variant IDH2. These mutations mostly involve Arg132 in ...