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UMC Repository: Recent submissions

  • Towards online MRI guided radiotherapy for pancreatic cancer 
    Heerkens, H.D. (Utrecht University, 2017-10-10)
    Pancreatic cancer is a devastating disease with a poor prognosis. Even after surgery with curative intent, life expectancy is poor. As the life span for these patients is limited, preventing deterioration of quality of ...
  • Ischaemic Heart Disease: Early Recognition and Risk Disparities 
    Bank, I.E.M. (Utrecht University, 2017-10-12)
    Ischaemic heart disease (IHD) comprises the principal clinical manifestations of coronary artery disease - myocardial infarction, stable and unstable angina pectoris, heart failure and sudden death - and is the leading ...
  • Heart Failure Care in General Practice 
    Valk, M.J.M. (Utrecht University, 2017-10-24)
    Heart failure (HF) is an increasing health care problem worldwide, and a multidisciplinary approach with a general practitioner (GP) in the health care team is considered optimal. HF management has improved substantially ...
  • Decision making in elderly patients with lung cancer 
    Schulkes, K.J.G. (Utrecht University, 2017-09-26)
    In the Netherlands, over 12.000 patients are diagnosed with lung cancer annually. It is mainly a disease of the elderly as half of the patients are over 70 years of age and 30% is older than 75 years. Benefit of treatment ...
  • From head to heart;: the effects of fetal growth restriction and preterm birth on the cerebral and systemic circulation 
    Cohen, Emily (Utrecht University, 2017-10-12)
    Fetal growth restriction (FGR) is the condition where a fetus does not grow according to its genetic growth potential. It is estimated that 3-7% of pregnancies are complicated by FGR. FGR has been associated with many ...
  • Optimizing systemic treatment in HER2-positive early breast cancer 
    van Ramshorst, M.S. (Utrecht University, 2017-10-31)
    Imaging can be used to evaluate the tumor response during and after neoadjuvant therapy with possibilities for response-based treatment adaptations. Positron emission tomography combined with computed tomography (PET/CT) ...
  • Methods for abdominal tumor ablation through image-guided focused ultrasound 
    Ramaekers, P. (Utrecht University, 2017-09-21)
    The work described in this thesis was aimed at developing and improving methods for extracorporeal image-guided focused ultrasound ablation of abdominal tumors. Main challenges that hamper the widespread clinical adoption ...
  • Doorsnijden van tumor bij hoofd-halskanker: een taboe? 
    De Bree, Remco; Willems, Stefan M.; Janssen, Luuk M.; Van Den Brekel, Michiel W M (Bohn Stafleu van Loghum, 2017)
    When resecting head and neck tumours, the aim is mostly to strive for en bloc resection with sufficiently large tumour-free margins. If this is not possible, as is frequently the case with transoral laser microsurgery and ...
  • Improving Comprehension Efficiency of High Content Screening Data Through Interactive Visualizations 
    Omta, Wienand A; Nobel, Jacob de; Klumperman, Judith; Egan, David A; Spruit, Marco R; Brinkhuis, Matthieu J S (Mary Ann Liebert Inc., 2017-08-25)
    In this study, an experiment is conducted to measure the performance in speed and accuracy of interactive visualizations. A platform for interactive data visualizations was implemented using Django, D3, and Angular. Using ...
  • Ultrastructural characterization of membrane rearrangements induced by porcine epidemic diarrhea virus infection 
    Zhou, Xingdong; Cong, Yingying; Veenendaal, Tineke; Klumperman, Judith; Shi, Dongfang; Mari, Muriel; Reggiori, Fulvio (Multidisciplinary Digital Publishing Institute (MDPI), 2017-09-05)
    The porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) belonging to the a-CoV genus and it causes high mortality in infected sucking piglets, resulting in substantial losses in the farming industry. CoV trigger ...
  • A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus 
    Kumar, Dilip; Puan, Kia Joo; Andiappan, Anand Kumar; Lee, Bernett; Westerlaken, Geertje H.A.; Haase, Doreen; Melchiotti, Rossella; Li, Zhuang; Yusof, Nurhashikin; Lum, Josephine; Koh, Geraldine; Foo, Shihui; Yeong, Joe; Alves, Alexessander Da Silva Couto; Pekkanen, Juha; Sun, Liang Dan; Irwanto, Astrid; Fairfax, Benjamin P.; Naranbhai, Vivek; Common, John E.A.; Tang, Mark B Y; Chuang, Chin Keh; Jarvelin, Marjo-Riitta; Knight, Julian C.; Zhang, Xuejun; Chew, Fook Tim; Prabhakar, Shyam; Jianjun, Liu; Wang, De Yun; Zolezzi, Francesca; Poidinger, Michael; Lane, E. Birgitte; Meyaard, Linde; Rötzschke, Olaf (BioMed Central, 2017-02-20)
    Background: Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under ...
  • Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging 
    Van Der Linden, Maarten; Westerlaken, Geertje H.A.; Van Der Vlist, Michiel; Van Montfrans, Joris; Meyaard, Linde (Nature Publishing Group, 2017-12-01)
    A wide variety of microbial and inflammatory factors induce DNA release from neutrophils as neutrophil extracellular traps (NETs). Consensus on the kinetics and mechanism of NET release has been hindered by the lack of ...
  • Immunotherapy holds the key to cancer treatment and prevention in constitutional mismatch repair deficiency (CMMRD) syndrome 
    Westdorp, Harm; Kolders, Sigrid; Hoogerbrugge, Nicoline; de Vries, I Jolanda M; Jongmans, Marjolijn C.J.; Schreibelt, Gerty (Elsevier Ireland Ltd, 2017-09-10)
    Monoallelic germline mutations in one of the DNA mismatch repair (MMR) genes cause Lynch syndrome, with a high lifetime risks of colorectal and endometrial cancer at adult age. Less well known, is the constitutional mismatch ...
  • Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus 
    Bakhshandeh, S.; Gorgin Karaji, Z.; Lietaert, K.; Fluit, A. C.; Boel, C. H.E.; Vogely, H. C.; Vermonden, T.; Hennink, Wim E.; Weinans, H.; Zadpoor, Amir A; Amin Yavari, S. (American Chemical Society, 2017-08-09)
    Implant-associated infections are notoriously difficult to treat and may even result in amputation and death. The first few days after surgery are the most critical time to prevent those infections, preferably through full ...
  • Factors associated with changes in health-related quality of life in children with cystic fibrosis during 1-year follow-up 
    van Horck, Marieke; Winkens, Bjorn; Wesseling, Geertjan; de Winter-de Groot, Karin; de Vreede, Ilja; Jöbsis, Quirijn; Dompeling, Edward (Springer-Verlag, 2017-08)
    There are limited data on health-related quality of life (HRQoL) changes over time in children with cystic fibrosis (CF). We investigated associations between clinical and treatment variables with changes in HRQoL during ...
  • Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort 
    Sarink, Danja; Schock, Helena; Johnson, Theron; Overvad, Kim; Holm, Marianne; Tjønneland, Anne; Boutron-Ruault, Marie Christine; His, Mathilde; Kvaskoff, Marina; Boeing, Heiner; Lagiou, Pagona; Papatesta, Eleni-Maria; Trichopoulou, Antonia; Palli, Domenico; Pala, Valeria; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, H B As; van Gils, Carla H; Peeters, Petra H; Weiderpass, Elisabete; Agudo, Antonio; Sánchez, Maria-José; Chirlaque, Maria-Dolores; Ardanaz, Eva; Amiano, Pilar; Khaw, Kay Tee; Travis, Ruth C.; Dossus, Laure; Gunter, Mark; Rinaldi, Sabina; Merritt, Melissa A.; Riboli, Elio; Kaaks, Rudolf; Turzanski-Fortner, Renée (American Association for Cancer Research Inc., 2017-09)
    Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer ...
  • Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia 
    Ly, Han; Verma, Nirmal; Wu, Fengen; Liu, Miao; Saatman, Kathryn E; Nelson, Peter T; Slevin, John T; Goldstein, Larry B; Biessels, Geert Jan; Despa, Florin (John Wiley & Sons Inc., 2017-08)
    OBJECTIVE: The brain blood vessels of patients with type 2 diabetes and dementia have deposition of amylin, an amyloidogenic hormone cosecreted with insulin. It is not known whether vascular amylin deposition is a consequence ...
  • Detection, risk factors, and functional consequences of cerebral microinfarcts 
    van Veluw, Susanne J; Shih, Andy Y; Smith, Eric E.; Chen, Christopher; Schneider, Julie A.; Wardlaw, Joanna M.; Greenberg, Steven M.; Biessels, Geert Jan (Elsevier Limited, 2017-09)
    Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the small size of these lesions, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measurable ...
  • Commentary: Treating submucous clefts with a double-opposing Z-plasty 
    Breugem, C. C. (Churchill Livingstone, 2017-05-01)
  • Een apotheker-farmacotherapeut in de praktijk 
    Sloeserwij, Vivianne (Bohn Stafleu van Loghum, 2017-01-11)