Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults
Boon, Eline; van der Graaf, Winette T A; Gelderblom, Hans; Tesselaar, Margot E T; van Es, Robert J.J.; Oosting, Sjoukje F; de Bree, Remco; van Meerten, Esther; Hoeben, Ann; Smeele, Ludi E.; Willems, Stefan M.; Witjes, Max J H; Buter, Jan; Baatenburg de Jong, Robert J; Flucke, Uta E.; Peer, Petronella G.M.; Bovée, Judith V.M.G.; Van Herpen, Carla M L
(2017) Head and Neck, volume 39, issue 1, pp. 140 - 146
(Article)
Abstract
Background: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck. Methods: All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed. Results: We
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identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively). Conclusion: In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy.
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Keywords: (neo-)adjuvant, chemotherapy, head and neck neoplasms, mandible, maxilla, osteosarcoma, Otorhinolaryngology, Journal Article
ISSN: 1043-3074
Publisher: John Wiley & Sons Inc.
Note: Publisher Copyright: © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
(Peer reviewed)
