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UMC Repository: Recent submissions

  • Prenatal detection of congenital heart disease - Results of a national screening programme 
    Van Velzen, C. L.; Clur, S. A.; Rijlaarsdam, M. E B; Bax, C. J.; Pajkrt, E.; Heymans, M. W.; Bekker, M. N.; Hruda, J.; De Groot, C. J M; Blom, N. A.; Haak, M. C. (Wiley-Blackwell, 2016-02-01)
    Objective Congenital heart disease (CHD) is the most common congenital malformation and causes major morbidity and mortality. Prenatal detection improves the neonatal condition before surgery, resulting in less morbidity ...
  • The effect of a decision aid on informed decision-making in the era of non-invasive prenatal testing: A randomised controlled trial 
    Beulen, Lean; Van Den Berg, Michelle; Faas, Brigitte Hw; Feenstra, Ilse; Hageman, Michiel; Van Vugt, John Mg; Bekker, Mireille N. (Springer Nature, 2016-10-01)
    Early in pregnancy women and their partners face the complex decision on whether or not to participate in prenatal testing for fetal chromosomal abnormalities. Several studies show that the majority of pregnant women ...
  • Functionele visusklachten: tijdig onderzoek loont 
    van Genderen, M M; de Wit, Gerard C; Riemslag, Frans C C (Bohn Stafleu van Loghum, 2016)
    Patients with functional vision disorder (FVD) may present with poor visual acuity, visual field loss, or a combination of the two. This paper illustrates the utility of objective tests in diagnosing FVD. We use sweep ...
  • Anteroinferior versus superior plating of clavicular fractures 
    Hulsmans, Martijn H J; Van Heijl, Mark; Houwert, Marijn; Timmers, Tim K.; Van Olden, Ger; Verleisdonk, Egbert Jan M M (Mosby Inc., 2016-03-01)
    Background: Open reduction and plate fixation has gained recognition as an effective treatment for certain types of clavicular fractures. However, 88% of cases report some implant-related problems. To determine the optimal ...
  • 4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer 
    De Marchi, Tommaso; Liu, Ning Qing; Stingl, Cristoph; Timmermans, Mieke A.; Smid, Marcel; Look, Maxime P.; Tjoa, Mila; Braakman, Rene B. H.; Opdam, Mark; Linn, Sabine C.; Sweep, Fred C. G. J.; Span, Paul N.; Kliffen, Mike; Luider, Theo M.; Foekens, John A.; Martens, John W. M.; Umar, Arzu (Elsevier, 2016-01)
    Estrogen receptor (ER) positive tumors represent the majority of breast malignancies, and are effectively treated with hormonal therapies, such as tamoxifen. However, in the recurrent disease resistance to tamoxifen therapy ...
  • Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer 
    De Marchi, Tommaso; Timmermans, Anne M.; Smid, Marcel; Look, Maxime P.; Stingl, Christoph; Opdam, Mark; Linn, Sabine C.; Sweep, Fred C. G. J.; Span, Paul N.; Kliffen, Mike; van Deurzen, Carolien H. M.; Luider, Theo M.; Foekens, John A.; Martens, John W.; Umar, Arzu (Impact Journals, 2016-01-19)
    Tamoxifen therapy resistance constitutes a major cause of death in patients with recurrent estrogen receptor (ER) positive breast cancer. Through high resolution mass spectrometry (MS), we previously generated a 4-protein ...
  • Comorbidities in Parkinson's disease, cause or consequence? 
    van den Bos, F. (Utrecht University, 2017-09-28)
    Parkinson’s disease (PD) is a common neurodegenerative disease, affecting approximately 1.8% of the population over the age of 65. The prevalence of PD and comorbidities increase with age and therefore many patients with ...
  • Motion management for MRI-guided abdominal radiotherapy 
    Stemkens, B. (Utrecht University, 2017-10-05)
    The recent introduction of hybrid MRI-linac (MRL) systems will drive a paradigm shift in radiotherapy. For the first time in history we have the ability to visualize both the tumor and surrounding healthy tissue before and ...
  • Cardiac CT in middle-aged athletes 
    Braber, T.L. (Utrecht University, 2017-07-03)
  • Cerebral monitoring during neonatal surgery for non-cardiac congenital anomalies: a first step to improve outcome? 
    Stolwijk, L.J. (Utrecht University, 2017-09-15)
    Monitoring the newborn brain during surgery Cerebral monitoring in newborns, who require surgery in the first month of life, is important to protect the brain. The newborn brain is vulnerable during neonatal surgery. Newborn ...
  • Videolaryngoscopy: a small step for men, a giant leap for mankind, a monumental leap foward in intubation technology 
    Pieters, B.M.A. (Utrecht University, 2017-09-12)
    Airway management is one of the mayor tasks of the anaesthetist, either in or outside the operating theatre. A secured airway can be achieved by placing a tracheal tube (TT) between the vocal cords of the patient. The most ...
  • Negotiating zoonoses: Dealings with infectious diseases shared by humans and livestock in the Netherlands (1898-2001) 
    Haalboom, A.F. (Utrecht University, 2017-09-21)
    This history studies how the domains of public health and agriculture have negotiated control over livestock-associated zoonoses in the Netherlands during the twentieth century, and how the disciplines of veterinary medicine ...
  • Lysosome Biogenesis and Autophagy 
    Reggiori, Fulvio; Klumperman, Judith (Wiley, 2016-06-27)
    Lysosomes degrade biological components acquired by endocytosis, the major cellular pathway for internalization of extracellular material, and macroautophagy. This chapter presents an overview of these two major degradative ...
  • Molecular origin of childhood acute lymphoblastic leukemia 
    Waanders, Esmé; Jongmans, Marjolijn C.J.; Mullighan, Charles G. (Springer International Publishing, 2016-03-18)
    Our understanding of the genetic etiology of pediatric acute lymphoblastic leukemia (ALL) has advanced greatly in the past few decades. Due to the advent of genome-wide profiling techniques for copy number alterations ...
  • ECCB 2016: The 15th European Conference on Computational Biology 
    Heringa, Jaap; Reinders, Marcel J T; Abeln, Sanne; De Ridder, Jeroen (Oxford University Press, 2016-09-01)
  • Antibioticaresistentie: gaat het nu echt mis? 
    Bonten, Marc J.M. (Bohn Stafleu van Loghum, 2016)
    In November 2015, plasmid-mediated colistin resistance in Gram-negative bacteria was reported for the first time, and it was evident that this newly-identified resistance gene (mcr-1) was already prevalent in the animal ...
  • The genomic characteristics and cellular origin of chromothripsis 
    Storchová, Zuzana; Kloosterman, Wigard P. (Elsevier Limited, 2016-06-01)
    Human genomes are continuously subjected to mutations, which can drive genetic diseases and cancer. An intriguing recent finding has been the discovery of chromothripsis, a spectacular and complex form of chromosome ...
  • Malnutrition in end stage liver disease: Who is malnourished? 
    Huisman, E.J. (Utrecht University, 2017-09-14)
    Liver diseases are highly prevalent. While death rates of most other diseases, such as heart disease and cancer, have decreased, standardized mortality rates of liver diseases have increased up to 400% in the last decades. ...
  • Transcriptional mechanisms regulating oncogenic TGF-β signaling in breast cancer 
    Lourenço, Ana Rita (Utrecht University, 2017-09-22)
    Breast cancer is the most common cancer worldwide in women contributing to 521,000 deaths per year. High mortality rate is due to the occurrence of metastasis, arising from cells that are able to detach from the primary ...
  • Acquiring Expertise in Radiology: Studies on Development & Assessment of Image Interpretation Skills 
    van der Gijp, A. (Utrecht University, 2017-09-19)
    Radiological image interpretation is a complex skill and requires years of training to master. To improve education and performance in radiological image interpretation, it is key to understand visual diagnostic reasoning. ...