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UMC Repository: Recent submissions

  • Early Stage Oral Squamous Cell Carcinoma: Treatment and Diagnostic Dilemmas 
    Dik, Eric Alexander (Utrecht University, 2019-10-15)
    In the treatment of early stage oral squamous cell carcinoma (OSCC) there has not been a substantial improvement in survival over the last three decades. To optimize future treatment results, it is relevant to critically ...
  • Epidemiology of varicella zoster virus in the Netherlands: Implications for vaccination strategies 
    van Lier, Elizabeth Aletta (Utrecht University, 2019-11-12)
    Varicella and herpes zoster are caused by the varicella zoster virus (VZV). At the first contact with this virus you will get varicella. Subsequently, the virus remains latent in your body and can become active again years ...
  • PAIN MANAGEMENT IN CHILDHOOD ACUTE OTITIS MEDIA 
    van Uum, Rick (Utrecht University, 2019-10-10)
    Ear pain remains central to children’s and parents’ experience of AOM and contributes significantly to AOM’s burden of disease. Our studies highlight that there is room for improvement of pain management in children with ...
  • Zalf of crème? De behandeling van eczeem 
    Bakker, Ilse; Sachs, Alfred; van der Velden, Alike (Bohn Stafleu van Loghum, 2019-09)
    Inleiding De richtlijnen adviseren eczeem in de acute fase te behandelen met lokale corticosteroïden en als onderhoudstherapie een crème of zalf te gebruiken. Een vettere substantie (vetcrème of zalf) beschermt de huid ...
  • Medical schools should ensure and improve global health education 
    de Zeeuw, Janine; van de Kamp, Judith; Browne, Joyce L (Elsevier, 2019-08-31)
  • Robustness of sepsis-3 criteria in critically ill patients 
    Verboom, Diana M; Frencken, Jos F; Ong, David S Y; Horn, Janneke; van der Poll, Tom; Bonten, Marc J M; Cremer, Olaf L; Klein Klouwenberg, Peter M C (Springer-Verlag GmbH and Co. KG, 2019-08-29)
    Background: Early recognition of sepsis is challenging, and diagnostic criteria have changed repeatedly. We assessed the robustness of sepsis-3 criteria in intensive care unit (ICU) patients. Methods: We studied the apparent ...
  • Older patients' experiences with a shared decision-making process on choosing dialysis or conservative care for advanced chronic kidney disease: a survey study: A survey study 
    Verberne, Wouter R.; Konijn, Wanda S.; Prantl, Karen; Dijkers, Janneke; Roskam, Margriet T.; Van Delden, Johannes J.M.; Bos, Willem Jan W. (BioMed Central, 2019-07-16)
    Background: Many older patients approaching end-stage kidney disease have to decide whether to go for dialysis or non-dialytic conservative care (CC). Shared decision-making is recommended to align the treatment plan with ...
  • Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress 
    van Opbergen, Chantal J M; Noorman, Maartje; Pfenniger, Anna; Copier, Jaël S; Vermij, Sarah H; Li, Zhen; van der Nagel, Roel; Zhang, Mingliang; de Bakker, Jacques M T; Glass, Aaron M; Mohler, Peter J; Taffet, Steven M; Vos, Marc A; van Rijen, Harold V M; Delmar, Mario; van Veen, Toon A B (Multidisciplinary Digital Publishing Institute (MDPI), 2019-08-21)
    Human variants in plakophilin-2 (PKP2) associate with most cases of familial arrhythmogenic cardiomyopathy (ACM). Recent studies show that PKP2 not only maintains intercellular coupling, but also regulates transcription ...
  • Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response 
    Van Wezel, E. M.; De Bruijne, J.; Damman, K.; Bijmolen, M.; Van Den Berg, A. P.; Verschuuren, E. A.M.; Ruigrok, G. A.; Riezebos-Brilman, A.; Knoester, M. (Oxford University Press, 2019-08-01)
    Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with ...
  • What should selective cardiometabolic prevention programmes in European primary care look like?: A consensus-based design by the SPIMEU group 
    Kral, Norbert; de Waard, Anne-Karien M.; Schellevis, Francois G.; Korevaar, Joke C.; Lionis, Christos; Carlsson, Axel C.; Sonderlund, Anders Larrabee; Sondergaard, Jens; Larsen, Lars Bruun; Hollander, Monika; Thilsing, Trine; Angelaki, Agapi; de Wit, Niek J.; Seifert, Bohumil (Informa Healthcare, 2019-07)
    Background: Selective prevention of cardiometabolic diseases (CMD)-that is, preventive measures specifically targeting the high-risk population-may represent the most effective approach for mitigating rising CMD rates. ...
  • Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses 
    Bernard, P; Savard, J; Steindorf, K; Sweegers, M G; Courneya, K S; Newton, R U; Aaronson, N K; Jacobsen, P B; May, A M; Galvao, D A; Chinapaw, M J; Stuiver, M M; Griffith, K A; Mesters, I; Knoop, H; Goedendorp, M M; Bohus, M; Thorsen, L; Schmidt, M E; Ulrich, C M; Sonke, G S; van Harten, W; Winters-Stone, K M; Velthuis, M J; Taaffe, D R; van Mechelen, W; Kersten, M J; Nollet, F; Wenzel, J; Wiskemann, J; Verdonck-de Leeuw, I M; Brug, J; Buffart, L M (Elsevier, 2019-09-01)
    OBJECTIVES: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these ...
  • Intrinsic Coagulation Pathway, History of Headache, and Risk of Ischemic Stroke 
    van Os, Hendrikus J. A.; Wermer, Marieke J. H.; Rosendaal, Frits R.; Govers-Riemslag, Jose W.; Algra, Ale; Siegerink, Bob S. (Lippincott Williams & Wilkins, 2019-08-01)
    Background and Purpose- Hypercoagulable states in migraine patients may play a role in the pathophysiology underlying the association between migraine and ischemic stroke. This study aims to provide more insight into the ...
  • Outcome Assessment by Central Adjudicators Versus Site Investigators in Stroke Trials: A Systematic Review and Meta-Analysis 
    Godolphin, Peter J.; Bath, Philip M.; Algra, Ale; Berge, Eivind; Brown, Martin M.; Chalmers, John; Duley, Lelia; Eliasziw, Misha; Gregson, John; Greving, Jacoba P.; Hankey, Graeme J.; Hosomi, Naohisa; Johnston, S. Claiborne; Patsko, Emily; Ranta, Annamarei; Sandset, Per Morten; Serena, Joaquin; Weimar, Christian; Montgomery, Alan A.; Knipp, S. C.; Giugliano, R. P.; Bonati, L. H.; Nagai, Y.; Matsumoto, M.; Barnett, H. J. M.; Fox, A. J.; Farrant, M.; Easton, J. D.; Elm, J. J.; Neal, B.; Arima, H.; Serena, J.; Davalos, A.; Amarenco, P.; Evans, S.; Sprigg, N.; Dineen, R.; Eikelboom, J. W.; Chen, C. (Lippincott Williams & Wilkins, 2019-08)
    Background and Purpose-In randomized stroke trials, central adjudication of a trial's primary outcome is regularly implemented. However, recent evidence questions the importance of central adjudication in randomized trials. ...
  • Nonfocal transient neurological attacks are related to cognitive impairment in patients with heart failure 
    Oudeman, Eline A.; Greving, Jacoba P.; Hooghiemstra, Astrid M.; Brunner-La Rocca, Hans-Peter; Biessels, Geert Jan; Kappelle, L. Jaap; Daemen, M. J.; van Buchem, M. A.; van der Geest, R. J.; van Osch, M. J. P.; de Roos, A.; van der Flier, W. M.; van Rossum, A. C.; La Rocca, H. P. Brunner; Ikram, M. A.; Koudstaal, P. J.; Niessen, W. J.; van Oostenbrugge, R.; Bots, M. L. (Springer Science and Business Media Deutschland GmbH, 2019-08)
    Introduction: Nonfocal transient neurological attacks (TNAs) are associated with an increased risk of future dementia, but it is unclear whether TNAs are also associated with concurrent cognitive impairment. We hypothesized ...
  • GRADE guidelines: 22. The GRADE approach for tests and strategies—from test accuracy to patient-important outcomes and recommendations 
    the GRADE Working Group (Elsevier, 2019-07-01)
    Objectives: This article describes the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group's framework of moving from test accuracy to patient or population-important outcomes. We focus ...
  • Healthcare costs of patients on different renal replacement modalities: Analysis of Dutch health insurance claims data 
    Mohnen, Sigrid M; van Oosten, Manon J M; Los, Jeanine; Leegte, Martijn J H; Jager, Kitty J; Hemmelder, Marc H; Logtenberg, Susan J J; Stel, Vianda S; Hakkaart-van Roijen, Leona; de Wit, G Ardine (Public Library of Science, 2019-08-15)
    BACKGROUND: The aim of this study is to present average annual healthcare costs for Dutch renal replacement therapy (RRT) patients for 7 treatment modalities. METHODS: Health insurance claims data from 2012-2014 were used. ...
  • Knowledge and perceptions of type 2 diabetes among Ghanaian migrants in three European countries and Ghanaians in rural and urban Ghana: The RODAM qualitative study 
    de-Graft Aikins, Ama; Dodoo, Francis; Awuah, Raphael Baffour; Owusu-Dabo, Ellis; Addo, Juliet; Nicolaou, Mary; Beune, Erik; Mockenhaupt, Frank P.; Danquah, Ina; Bahendeka, Silver; Meeks, Karlijn; Klipstein-Grobusch, Kirstin; Afrifa-Anane, Ernest; Smeeth, Liam; Stronks, Karien; Agyemang, Charles (Public Library of Science, 2019-04-02)
    African migrants in Europe and continental Africans are disproportionately affected by type 2 diabetes (T2D). Both groups develop T2D at a younger age, and have higher morbidity and mortality from T2D and complications, ...
  • Is social support associated with hypertension control among Ghanaian migrants in Europe and non-migrants in Ghana? The RODAM study 
    Nyaaba, Gertrude Nsorma; Stronks, Karien; Meeks, Karlijn; Beune, Erik; Owusu-Dabo, Ellis; Addo, Juliet; de-Graft Aikins, Ama; Mockenhaupt, Frank; Bahendeka, Silver; Klipstein-Grobusch, Kerstin; Smeeth, Liam; Agyemang, Charles (Springer Verlag Italia, 2019-09-01)
    Hypertension (HTN) control is crucial in preventing HTN-related complications such as stroke and coronary heart disease. Yet, HTN control remains suboptimal particularly among sub-Saharan African (SSA) populations partly ...
  • The effect of an mHealth clinical decision-making support system on neonatal mortality in a low resource setting: A cluster-randomized controlled trial 
    Amoakoh, Hannah Brown; Klipstein-Grobusch, Kerstin; Agyepong, Irene Akua; Zuithoff, Nicolaas P.A.; Amoakoh-Coleman, Mary; Kayode, Gbenga A.; Sarpong, Charity; Reitsma, Johannes B.; Grobbee, Diederick E.; Ansah, Evelyn K. (Elsevier, 2019-07-01)
    Background: MHealth interventions promise to bridge gaps in clinical care but documentation of their effectiveness is limited. We evaluated the utilization and effect of an mhealth clinical decision-making support intervention ...
  • EU postmarket surveillance plans for medical devices 
    Pane, Josep; Francisca, Reynold D. C.; Verhamme, Katia M. C.; Orozco, Marcia; Viroux, Hilde; Rebollo, Irene; Sturkenboom, Miriam C. J. M. (John Wiley & Sons Inc., 2019-09-01)
    Purpose: Recent public health safety issues involving medical devices have led to a growing demand to improve the current passive-reactive postmarket surveillance (PMS) system. Various European Union (EU) national competent ...