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UMC Repository: Recent submissions

  • Characterization and manipulation of feeding-related neural circuits 
    Goes-Roelofs, Theresia Johanna Maria (Utrecht University, 2019-11-07)
    This thesis contributed to building bridges between different levels of understanding in current neuroscience research on regulation of feeding related behavior: we aimed to show the translational value of rodents studies ...
  • Quantitative MRI markers for the brain at risk 
    van der Kleij, Lisa Annette (Utrecht University, 2019-10-24)
    The aim of this thesis was to explore applications of three selected, quantitative MRI makers: cerebral perfusion, the T2 of peripheral cerebrospinal fluid (CSF) and volumetric measures. The studied populations share a ...
  • Gene Control in 3D: The Roles of CTCF and Chromatin Looping in Organizing a Functional Genome 
    Vos, Erica Suzanna Marita (Utrecht University, 2019-10-31)
    It is now well established that genome organization plays a major role in its functioning. Enhancers act as genetic switches to activate transcription at gene promoters, a process which forms chromatin loops. Other loops ...
  • Molecular Diagnostics among Patients with Gastroenteritis in General Practice 
    Schierenberg, Alwin (Utrecht University, 2019-10-29)
    Gastroenteritis (GE) is one of the most frequently occurring infectious disease and has a relatively high consultation rate in general practice. In the Netherlands, 5 to 12% of patients with GE consult their general ...
  • Cardiovascular drug target discovery: In vitro and in vivo validation studies 
    van Keulen, Daniëlle (Utrecht University, 2019-10-24)
    Despite the increase in knowledge about cardiovascular diseases and the increase in available drugs since the beginning of the 20th century, one out of three people still dies from cardiovascular diseases. In more than 50% ...
  • Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer 
    Butt, Julia; Jenab, Mazda; Pawlita, Michael; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Mancini, Francesca Romana; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Karakatsani, Anna; Palli, Domenico; Pala, Valeria Maria; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, Bas; van Gils, Carla H; Vermeulen, Roel C H; Weiderpass, Elisabete; Quirós, José Ramón; Duell, Eric Jeffrey; Sánchez, Maria-Jose; Dorronsoro, Miren; Huerta, José María; Ardanaz, Eva; Van Guelpen, Bethany; Harlid, Sophia; Perez-Cornago, Aurora; Gunter, Marc J; Murphy, Neil; Freisling, Heinz; Aune, Dagfinn; Waterboer, Tim; Hughes, David J (American Association for Cancer Research Inc., 2019-09)
    BACKGROUND: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are ...
  • Completeness of obstetric referral letters/notes from subdistrict to district level in three rural districts in Greater Accra region of Ghana: an implementation research using mixed methods 
    Amoakoh-Coleman, Mary; Ansah, Evelyn; Klipstein-Grobusch, Kerstin; Arhinful, Daniel (BMJ Publishing Group, 2019-09-01)
    OBJECTIVE: To assess the completeness of obstetric referral letters/notes at the district level of healthcare. DESIGN: An implementation research within three districts in Greater Accra region using mixed methods. During ...
  • Determinants of Patient Delay in Transient Ischemic Attack 
    Dolmans, L. Servaas; Hoes, Arno W.; Bartelink, Marie Louise E.L.; Kappelle, L. Jaap; Rutten, Frans H. (S. Karger AG, 2019-08-01)
    Introduction: Early diagnosis and stroke preventive treatment in patients with transient ischemic attack (TIA) are crucial, but hampered by delayed reporting of symptoms. Previous studies on causes of patient delay provided ...
  • Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study 
    Danquah, Ina; Addo, Juliet; Boateng, Daniel; Klipstein-Grobusch, Kerstin; Meeks, Karlijn; Galbete, Cecilia; Beune, Erik; Bahendeka, Silver; Spranger, Joachim; Mockenhaupt, Frank P.; Stronks, Karien; Agyemang, Charles; Schulze, Matthias B.; Smeeth, Liam (Nature Publishing Group, 2019-07-26)
    Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist ...
  • A post-hoc analysis of serotype-specific vaccine efficacy of 13-valent pneumococcal conjugate vaccine against clinical community acquired pneumonia from a randomized clinical trial in the Netherlands 
    Gessner, Bradford D.; Jiang, Qin; Van Werkhoven, Cornelis H.; Sings, Heather L.; Webber, Chris; Scott, Daniel; Gruber, William C.; Grobbee, Diederick E.; Bonten, Marc J. M.; Jodar, Luis (Elsevier, 2019-07-09)
    Background: Serotype-specific vaccine efficacy (VE) against adult community acquired pneumonia (CAP) remains poorly defined, yet such data are important for assessing the utility of adult pneumococcal conjugate vaccine ...
  • Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis 
    Greving, Jacoba P.; Diener, Hans-Christoph; Reitsma, Johannes B.; Bath, Philip M.; Csiba, Laszlo; Hacke, Werner; Kappelle, L. Jaap; Koudstaal, Peter J.; Leys, Didier; Mas, Jean-Louis; Sacco, Ralph L.; Algra, Ale (Lippincott Williams & Wilkins, 2019-07)
    Background and Purpose-We assessed the efficacy and safety of antiplatelet agents after noncardioembolic stroke or transient ischemic attack and examined how these vary according to patients' demographic and clinical ...
  • Beter af bij de verpleegkundig specialist?: Een cohortonderzoek bij kinderen met luchtweginfecties 
    van Vugt, Saskia; van de Pol, Alma; Cleveringa, Frits; Stellato, Rebecca; Kappers, Marieke; de Wit, Niek; Damoiseaux, Roger (Bohn Stafleu van Loghum, 2019-04-01)
    Inleiding Verpleegkundig specialisten nemen steeds meer patiëntenzorg van de huisarts over, waaronder die voor kinderen met luchtweginfecties. Deze substitutie door geprotocolleerde zorg zou kunnen zorgen voor betere ...
  • Predictors of dropout in interdisciplinary chronic pain management programmes: A systematic review 
    Oosterhaven, Janke; Wittink, Harriet; Mollema, Jurgen; Kruitwagen, Cas; Devillé, Walter (Medical Journals Sweden AB, 2019)
    Objective: Systematic review to identify predictors for dropout during interdisciplinary pain management programmes. Data sources: PubMed, PsycINFO, CINAHL, Embase, and SPORTDiscus were searched from inception to 22 June ...
  • Association of plasma Vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study 
    Zheng, Ju Sheng; Imamura, Fumiaki; Sharp, Stephen J.; Van Der Schouw, Yvonne T.; Sluijs, Ivonne; Gundersen, Thomas E.; Ardanaz, Eva; Boeing, Heiner; Bonet, Catalina; Gómez, Jesus Humberto; Dow, Courtney; Fagherazzi, Guy; Franks, Paul W.; Jenab, Mazda; Kuhn, Tilman; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay Tee; Lasheras, Cristina; Mokoroa, Olatz; Mancini, Francesca Romana; Nilsson, Peter M.; Overvad, Kim; Panico, Salvatore; Palli, Domenico; Rolandsson, Olov; Sieri, Sabina; Salamanca-Fernández, Elena; Sacerdote, Carlotta; Spijkerman, Annemieke M.W.; Stepien, Magdalena; Tjonneland, Anne; Tumino, Rosario; Butterworth, Adam S.; Riboli, Elio; Danesh, John; Langenberg, Claudia; Forouhi, Nita G.; Wareham, Nicholas J. (Endocrine Society, 2019-04-01)
    Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its ...
  • A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics 
    De Rooij, Myrna M.T.; Van Leuken, Jeroen P.G.; Swart, Arno; Kretzschmar, Mirjam E.E.; Nielen, Mirjam; De Koeijer, Aline A.; Janse, Ingmar; Wouters, Inge M.; Heederik, Dick J.J. (Wiley-Blackwell, 2019-02)
    From 2007 through 2010, the Netherlands experienced the largest Q fever epidemic ever reported. This study integrates the outcomes of a multidisciplinary research programme on spatial airborne transmission of Coxiella ...
  • Cognitive impairment in type 2 diabetes: Opportunities for diagnosis, prevention and management 
    Janssen, Jolien (Utrecht University, 2019-10-29)
    In the Netherlands, hundreds of thousands of people aged 70 years or older are currently living with type 2 diabetes, and these numbers are expected to increase further. Older people with type 2 diabetes have an increased ...
  • Treatment decision making in patients with prostatic disorders 
    Lamers, Romy Eleonora Desideria (Utrecht University, 2019-11-21)
    Shared decision making is applied in order to choose the best treatment option, adjusted to the patients’ individual preferences and values. Decision aids are instruments which can be used to support shared decision making ...
  • Viral respiratory infections in adults: Focus on RSV and rapid molecular diagnostic testing 
    Vos, Laura Marion (Utrecht University, 2019-11-07)
    Respiratory viruses are associated with a high disease burden among adults. Over the last years, respiratory syncytial virus (RSV) has been increasingly recognized as an important cause of illness in adults. In the first ...
  • Societal impact of sepsis and inflammation in the ICU and beyond 
    Brouwer, Maria Elizabet (Utrecht University, 2019-10-22)
    Sepsis is a common cause and complication of an admission to an intensive care unit (ICU) and is associated with high morbidity and mortality. In this thesis, the societal impact of sepsis and inflammation was estimated ...
  • Applicability of corticosteroid releasing microspheres in degenerative joint diseases 
    Rudnik-Jansen, Imke (Utrecht University, 2019-10-22)
    Osteoarthritis (OA) and intervertebral disc (IVD) degeneration are two musculoskeletal conditions that can seriously affect the quality of life of individual patients, strain health and social care systems and thereby the ...