Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response

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Sofosbuvir add-on to ribavirin treatment for chronic hepatitis e virus infection in solid organ transplant recipients does not result in sustained virological response
 
Van Wezel, E. M.; De Bruijne, J.; Damman, K.; Bijmolen, M.; Van Den Berg, A. P.; Verschuuren, E. A.M.; Ruigrok, G. A.; Riezebos-Brilman, A.; Knoester, M.
(2019) Open forum infectious diseases, volume 6, issue 8
(Article)
Abstract
Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.
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Keywords: chronic hepatitis E, sofosbuvir, solid organ transplant recipients, Journal Article
DOI: https://doi.org/10.1093/ofid/ofz346
ISSN: 2328-8957
Publisher: Oxford University Press
Note: © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
(Peer reviewed)