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Now showing items 23921-23940 of 40729

Bottom-up development of national obstetric guidelines in middle-income country Suriname

Verschueren, Kim J C; Kodan, Lachmi R; Brinkman, Tom K; Paidin, Raez R; Henar, Sheran S; Kanhai, Humphrey H H; Browne, Joyce L; Rijken, Marcus J; Bloemenkamp, Kitty W M (BioMed Central, 2019-09-09)

BACKGROUND: Obstetric guidelines are useful to improve the quality of care. Availability of international guidelines has rapidly increased, however the contextualization to enhance feasibility of implementation in health ...
The Dutch Parelsnoer Institute Cerebrovascular Disease Initiative: A retrospective study of the effects of integrating clinical care and research on costs and quality of care in patients with ischaemic stroke

Mensing, Liselore A.; Kappelle, Jaap; Buijs, Julie E.; Luijckx, Gert Jan; Koffijberg, Hendrik; Zielhuis, Gerhard A.; Ruigrok, Ynte M. (BMJ Publishing Group, 2019-08-27)

INTRODUCTION: The Dutch Parelsnoer Institute (PSI) is a collaboration between all university medical centres in which clinical data, imaging and biomaterials are prospectively and uniformly collected for research purposes. ...
Transcatheter Tricuspid Valve Interventions: An Emerging Field

Gheorghe, Livia; Rensing, Benno J.W.M.; Van der Heyden, Jan A.S.; Eefting, Frank D.; Post, Martijn C.; Rana, Bushra; Swaans, Martin J. (Springer, 2019-03-28)

PURPOSE OF REVIEW: This review aims to provide an updated overview and a clinical perspective on novel transcatheter tricuspid valve interventions (TTVI), highlighting potential challenges and future directions. RECENT ...
Non-Vitamin K antagonist oral anticoagulants in adults with a Fontan circulation: Are they safe

Yang, Hayang; Veldtman, Gruschen R.; Bouma, Berto J.; Budts, Werner; Niwa, Koichiro; Meijboom, Folkert; Scognamiglio, Giancarlo; Egbe, Alexander Chima; Schwerzmann, Markus; Broberg, Craig; Morissens, Marielle; Buber, Jonathan; Tsai, Shane; Polyzois, Ioannis; Post, Martijn C.; Greutmann, Matthias; Van Dijk, Arie; Mulder, Barbara J.M.; Aboulhosn, Jamil (BMJ Publishing Group, 2019-06-01)

Background In Fontan patients with atrial arrhythmias (AA), non-Vitamin K antagonist oral anticoagulants(NOACs) have a class III recommendation according to the Pediatric & Congenital Electrophysiology Society (PACES)/Heart ...
Clinical characteristics and genetic analyses of 187 patients with undefined autoinflammatory diseases

Eurofever registry and the Pediatric Rheumatology International Trial Organization (PRINTO) (Elsevier, 2019-10-01)

OBJECTIVES: To describe the clinical characteristics, treatment response and genetic findings in a large cohort of patients with undefined systemic autoinflammatory diseases (SAIDs). METHODS: Clinical and genetic data from ...
Long-term clinical value and outcome of riociguat in chronic thromboembolic pulmonary hypertension

van Thor, M. C.J.; ten Klooster, L.; Snijder, R. J.; Post, M. C.; Mager, J. J. (Elsevier, 2019-03-01)

Background: To improve clinical outcome, patients with inoperable and residual chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with riociguat. The aim of this study is to explore long-term outcomes and ...
Safety of direct oral anticoagulants in patients with hereditary hemorrhagic telangiectasia

Shovlin, C. L.; Millar, C. M.; Droege, F.; Kjeldsen, A.; Manfredi, G.; Suppressa, P.; Ugolini, S.; Coote, N.; Fialla, A. D.; Geisthoff, U.; Lenato, G. M.; Mager, H. J.; Pagella, F.; Post, M. C.; Sabbà, C.; Sure, U.; Torring, P. M.; Dupuis-Girod, S.; Buscarini, E. (BioMed Central, 2019-08-28)

Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular dysplasia resulting in visceral arteriovenous malformations and smaller mucocutaneous telangiectasia. Most patients experience recurrent nosebleeds ...
Red Blood Cells: Chasing Interactions

Pretini, Virginia; Koenen, Mischa H; Kaestner, Lars; Fens, Marcel H A M; Schiffelers, Raymond M; Bartels, Marije; Van Wijk, Richard (Frontiers Research Foundation, 2019-07-31)

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and most intracellular machineries during their maturation process. RBC are fundamental for the nearly all basic physiologic dynamics ...
Redispensing of unused HIV post-exposure prophylaxis for medical students

Bekker, Charlotte L; Kalicharan, Raween W; Melis, Eward J; Gardarsdottir, Helga; van den Bemt, Bart J F; Bouvy, Marcel L; van Maarseveen, Erik M; Egberts, Antoine C G (Elsevier, 2019-05-01)
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Theelen, Willemijn S M E; Kuilman, Thomas; Schulze, Katja; Zou, Wei; Krijgsman, Oscar; Peters, Dennis D G C; Cornelissen, Sten; Monkhorst, Kim; Sarma, Pranamee; Sumiyoshi, Teiko; Amler, Lukas C; Willems, Stefan M; Blaauwgeers, Johannes L G; van Noesel, Carel J M; Peeper, Daniel S; van den Heuvel, Michel M; Kowanetz, Marcin (Public Library of Science, 2019-05-24)

Background In non-small cell lung cancer (NSCLC), PD-L1 expression on either tumor cells (TC) or both TC and tumor-infiltrating immune cells (IC) is currently the most used biomarker in cancer immunotherapy. However, the ...
Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh)

Veerman, Christiaan C; Mengarelli, Isabella; Koopman, Charlotte D; Wilders, Ronald; van Amersfoorth, Shirley C; Bakker, Diane; Wolswinkel, Rianne; Hababa, Mariam; de Boer, Teun P; Guan, Kaomei; Milnes, James; Lodder, Elisabeth M; Bakkers, Jeroen; Verkerk, Arie O; Bezzina, Connie R (Company of Biologists Ltd, 2019-07-09)

Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the ...
Hormonal contraceptives and the acquisition of sexually transmitted infections: an updated systematic review

McCarthy, Katharine J; Gollub, Erica L; Ralph, Lauren; van de Wijgert, Janneke; Jones, Heidi E (Lippincott Williams & Wilkins, 2019-05-01)

BACKGROUND: Evidence suggests that some forms of hormonal contraception (HC) increase women's risk of non-human immunodeficiency virus sexually transmitted infections (STIs), yet evidence has not been reviewed since 2008. ...
Incidence, severity and outcome of central line related complications in pediatric oncology patients; A single center study

van den Bosch, Ceder H.; van der Bruggen, J. Tjomme; Frakking, Florine N.J.; Terwisscha van Scheltinga, Cecilia E.J.; van de Ven, Cornelis P.; van Grotel, Martine; Wellens, Lianne M.; Loeffen, Yvette G.T.; Fiocco, Marta; Wijnen, Marc H.W.A. (W.B. Saunders, 2019-09)

Background: Central venous access device (CVAD)-related complications are associated with high morbidity rates. This study was performed to underline the importance of CVAD-complication prevention and treatment. Methods: ...
Cytokinesis defects and cancer

Lens, Susanne M.A.; Medema, René H. (Nature Publishing Group, 2019-01)

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is in fact an important cause of human cancers has ...
Development of hand function during the first year of life in children with unilateral cerebral palsy

Sakzewski, Leanne; Sicola, Elisa; Verhage, Cornelia H.; Sgandurra, Giuseppina; Eliasson, Ann Christin (Wiley-Blackwell, 2019-05)

Aim: To identify developmental trajectories of hand function in infants aged 3 months to 12 months with unilateral cerebral palsy (CP). Method: Infants at high risk of unilateral CP were recruited from 3 months of age from ...
A single preoperative blood test predicts postoperative sepsis and pneumonia after coronary bypass or open aneurysm surgery

van Koeverden, Ian D.; den Ruijter, Hester M.; Scholtes, Vincent P.W.; G. E. H. Lam, Marnix; Haitjema, Saskia; Buijsrogge, Marc P.; J. L. Suyker, Willem; van Wijk, Richard H.; de Groot, Mark C.H.; van Herwaarden, Joost A.; van Solinge, Wouter W.; de Borst, Gert J.; Pasterkamp, Gerard; Hoefer, Imo E. (Wiley-Blackwell, 2019-03)

Background: Major surgery comes with a high risk for postoperative inflammatory complications. Preoperative risk scores predict mortality risk but fail to identify patients at risk for complications following cardiovascular ...
Treat to target (drug-free) inactive disease in DMARD-naive juvenile idiopathic arthritis: 24-month clinical outcomes of a three-armed randomised trial

Hissink Muller, Petra; Brinkman, Danielle M.C.; Schonenberg-Meinema, Dieneke; Van Den Bosch, Wytse Bastiaan; Koopman-Keemink, Yvonne; Brederije, Isabel C.J.; Bekkering, Peter W.; Kuijpers, Taco W.; Van Rossum, Marion; Van Suijlekom-Smit, Lisette W.A.; Van Den Berg, J. Merlijn; Boehringer, Stefan; Allaart, Cornelia F.; Ten Cate, R. (Elsevier, 2019-01)

Question: Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)? Methods: In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive ...
Evaluation of Left Ventricular Function Long Term After Arterial Switch Operation for Transposition of the Great Arteries

van Wijk, S. W.; Driessen, M. M.P.; Meijboom, F. J.; Takken, T.; Doevendans, P. A.; Breur, J. M. (Springer New York, 2019-01)

Long-term after arterial switch operation for transposition of the great arteries, abnormal coronary anatomy and altered loading conditions could compromise ventricular function. The current study investigates whether left ...
Wilms Tumor: Towards integration of histopathological and genomic characteristics

Ooms, Ariadne Helena Anna Geertruda (Utrecht University, 2019-11-12)

Wilms Tumor (WT) is the most common pediatric renal tumor, accounting for ~90% of cases. Postoperative treatment stratification of WTs is mainly based on histological subclassification of the surgical specimen. High-risk ...
Image-Guided High Intensity Focused Ultrasound-based Boiling Histotripsy for Treatment of Neuroblastoma

Eranki, Avinash (Utrecht University, 2019-10-30)

Recent advances in non-invasive therapies combined with the growing field of immunotherapy may enable safer and more efficacious treatments of solid tumors. Neuroblastoma is a solid tumor that is presented as an embryonal ...

Now showing items 23921-23940 of 40729