Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 23901-23920 of 40729

Cross-sectional study of association between psychosocial stressors with chronic kidney disease among migrant and non-migrant Ghanaians living in Europe and Ghana: The RODAM study

Adjei, David Nana; Stronks, Karien; Adu, Dwomoa; Beune, Erik; Meeks, Karlijn; Smeeth, Liam; Addo, Juliet; Owusu-Dabo, Ellis; Klipstein-Grobusch, Kerstin; Mockenhaupt, Frank; Schulze, Matthias; Danquah, Ina; Spranger, Joachim; Bahendeka, Silver Karaireho; Agyemang, Charles (BMJ Publishing Group, 2019-08-01)

Objectives: The association between psychosocial stressors (PS) and chronic kidney disease (CKD) among sub-Saharan African (SSA) populations is unknown. We examined the association between PS and CKD prevalence among rural ...
Post-marketing dosing changes in the label of biologicals

Minnema, Lotte A; Giezen, Thijs J; Gardarsdottir, Helga; Egberts, Antoine C G; Leufkens, Hubert G M; Mantel-Teeuwisse, Aukje K (Wiley-Blackwell, 2019-04-01)

Aim: The aim of this study was to evaluate post-marketing label changes in dosing information of biologicals. Methods: Biologicals authorized between 2007 and 2014 by the European Medicines Agency (EMA) were included and ...
Driving Medical Innovation Through Interdisciplinarity: Unique Opportunities and Challenges

Gohar, Faekah; Maschmeyer, Patrick; Mfarrej, Bechara; Lemaire, Mathieu; Wedderburn, Lucy R; Roncarolo, Maria Grazia; van Royen-Kerkhof, Annet (Frontiers Media S. A., 2019-02-26)
Facilitators and barriers to brokering between research and care by senior clinical-scientists in general practice and elderly care medicine

Bartelink, Marie-Louise El; Baggen, Yvette; Stevens, Diede E; Smalbrugge, Martin; Scherpbier, Nynke; Damoiseaux, Roger Amj; de Groot, Esther (Taylor and Francis Ltd., 2019-03)

BACKGROUND: Clinician-scientists (CSs) are physicians who work in daily care and have an academic role in research or education. They may act as knowledge brokers and help to connect research and clinical practice. There ...
Sex Differences in Coronary Artery and Thoracic Aorta Calcification and Their Association With Cardiovascular Mortality in Heavy Smokers

Lessmann, Nikolas; de Jong, Pim A; Celeng, Csilla; Takx, Richard A P; Viergever, Max A; van Ginneken, Bram; Išgum, Ivana (Elsevier, 2019-09-01)

OBJECTIVES: The aim of this study was to investigate sex differences in the prevalence, extent, and association of coronary artery calcium (CAC) and thoracic aorta calcium (TAC) scores with cardiovascular mortality in a ...
Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation

Ustun, Celalettin; Young, Jo-Anne H; Papanicolaou, Genovefa A; Kim, Soyoung; Ahn, Kwang Woo; Chen, Min; Abdel-Azim, Hisham; Aljurf, Mahmoud; Beitinjaneh, Amer; Brown, Valerie; Cerny, Jan; Chhabra, Saurabh; Kharfan-Dabaja, Mohamed A; Dahi, Parastoo B; Daly, Andrew; Dandoy, Christopher E; Dvorak, Christopher C; Freytes, Cesar O; Hashmi, Shahrukh; Lazarus, Hillard; Ljungman, Per; Nishihori, Taiga; Page, Kristin; Pingali, Sai R K; Saad, Ayman; Savani, Bipin N; Weisdorf, Daniel; Williams, Kirsten; Wirk, Baldeep; Auletta, Jeffery J; Lindemans, Caroline A; Komanduri, Krishna; Riches, Marcie (Springer Nature, 2019-08)

We analyzed CIBMTR data to evaluate the incidence of non-relapse mortality (NRM) and association with overall survival (OS) for bacterial blood stream infections (BSIs) occurring within 100 days of alloHCT in 2 different ...
How I manage children with Diamond-Blackfan anaemia

Bartels, Marije; Bierings, Marc (Wiley-Blackwell, 2019-01)

Diamond-Blackfan anaemia (DBA) is a rare inherited marrow failure disorder, characterized by hypoplastic anaemia, congenital anomalies and a predisposition to cancer as a result of ribosomal dysfunction. Historically, ...
Artifact Correction and Signal Quantification in High Field Breast MRI

van Rijssel, Michael J (Utrecht University, 2019-11-26)

This thesis investigates artifact correction and signal quantification in high field breast MRI. We focus on dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI). DCE-MRI is sensitive to inhomogeneities ...
Local and systemic profiles of inflammation, adaptation and regulation at the interface between tissue and immunity: Juvenile Dermatomyositis and beyond

Wienke, Judith (Utrecht University, 2019-11-14)

Inflammation is the body’s natural reaction to fight infections. During inflammation, cells of the immune system, like T cells, move from the bloodstream into inflamed tissues. Specific signaling molecules are released ...
The role of early oral feeding in improving surgical recovery after esophagectomy

Berkelmans, Gijs H K (Utrecht University, 2019-11-28)

The feeding route after an esophagectomy was systematically reviewed in Chapter 2. The majority of patients were scheduled for a nil-by-mouth period for 1 week after surgery and received enteral feeding through a jejunostomy ...
Sepsis in the ICU: improving pathogen detection and understanding of infectious complications

van de Groep, Kirsten (Utrecht University, 2019-10-22)

Timely recognition, initiation of appropriate antimicrobial therapy, and prompt control over the anatomic source of the infection are pivotal for improving patient outcome in sepsis. The first part of this thesis describes ...
Healthcare decision-making at the end of life in South-East Asia: Ethical and legal perspectives

Menon, Sumytra (Utrecht University, 2019-11-05)

Patients, families and healthcare professionals often face ethically challenging choices at the end of life, and some of those choices may have been shaped by the law. Making healthcare decisions in the context of critical ...
Effects of cerebral small vessel disease in the brain beyond the visible lesions

Heinen, Rutger (Utrecht University, 2019-12-19)

Diseases of the brain’s small blood vessels (cerebral small vessel disease or SVD) are common. SVD is one of the major causes of stroke and dementia. Brain damage due to SVD can be seen on a normal MRI-scan. However, it ...
High-risk melanoma patients - identification, surgical management and follow-up

Nijhuis, Amanda Anna Gertruda (Utrecht University, 2019-11-14)

This thesis concerns the identification of these patients with high-risk melanoma, their surgical management, and follow-up. Patients with stage III melanoma are frequently identified through sentinel node biopsy (SNB). ...
Challenges in managing urinary tract infection and the potential of a point-of-care test guided care in primary care: an international qualitative study

Brookes-Howell, Lucy; Thomas-Jones, Emma; Bates, Janine; Bekkers, Marie-Jet; Brugman, Curt; Coulman, Elinor; Francis, Nick; Hashmi, Khurram; Hood, Kerenza; Kirby, Nigel; Llor, Carl; Little, Paul; Moore, Michael; Moragas, Anna; Rumsby, Kate; Verheij, Theo; Butler, Christopher (Royal College of General Practitioners, 2019-07)

BACKGROUND: Little is known about clinicians' experiences of using a point-of-care test (POCT) to inform management of urinary tract infection (UTI) in general practice. AIM: To explore experiences of using the Flexicult ...
Factors influencing safe glucose-lowering in older adults with type 2 diabetes: A PeRsOn-centred ApproaCh To IndiVidualisEd (PROACTIVE) Glycemic Goals for older people: A position statement of Primary Care Diabetes Europe

Hambling, C. E.; Khunti, K.; Cos, X.; Wens, J.; Martinez, L.; Topsever, P.; Del Prato, S.; Sinclair, A.; Schernthaner, G.; Rutten, G.; Seidu, S. (Elsevier, 2019-08-01)

Diabetes in later life is associated with a range of factors increasing the complexity of glycaemic management. This position statement, developed from an extensive literature review of the subject area, represents a ...
Individualised targets for insulin initiation in type 2 diabetes mellitus - The influence of physician and practice: A cross-sectional study in eight European countries

Boels, Anne Meike; Koning, Elwin; Vos, Rimke C.; Khunti, Kamlesh; Rutten, Guy E.H.M. (BMJ Publishing Group, 2019-08-26)

Objectives To determine at what glycated haemoglobin (HbA1c) level physicians from eight European countries would initiate insulin in type 2 diabetes, which physician or practice related factors influenced this level and ...
De draagbare kunstnier: hoe staan de zaken?

Wester, Maarten; van Gelder, Maaike K; Joles, Jaap A; Verhaar, Marianne C; Kooman, Jeroen P; Gerritsen, Karin G F (Bohn Stafleu van Loghum, 2019-07-04)

Portable dialysis devices enable dialysis patients to dialyse at home, thereby enhancing their mobility and autonomy. The development of a strategy to facilitate re-use of dialysate is crucial in the deployment of these ...
Adjustment for index event bias in genome-wide association studies of subsequent events

Dudbridge, Frank; Allen, Richard J.; Sheehan, Nuala A.; Schmidt, A. Floriaan; Lee, James C.; Jenkins, R. Gisli; Wain, Louise V.; Hingorani, Aroon D.; Patel, Riyaz S. (Nature Publishing Group, 2019-04-05)

Following numerous genome-wide association studies of disease susceptibility, there is increasing interest in genetic associations with prognosis, survival or other subsequent events. Such associations are vulnerable to ...
When drug treatments bias genetic studies: Mediation and interaction

Schmidt, Amand F.; Heerspink, Hiddo J.L.; Denig, Petra; Finan, Chris; Groenwold, Rolf H.H. (Public Library of Science, 2019-08-28)

Background Increasingly, genetic analyses are conducted using information from subjects with established disease, who often receive concomitant treatment. We determined when treatment may bias genetic associations with a ...

Now showing items 23901-23920 of 40729