Red Blood Cells: Chasing Interactions
Pretini, Virginia; Koenen, Mischa H; Kaestner, Lars; Fens, Marcel H A M; Schiffelers, Raymond M; Bartels, Marije; Van Wijk, Richard
(2019) Frontiers in Physiology, volume 10, issue JUL
(Article)
Abstract
Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and most intracellular machineries during their maturation process. RBC are fundamental for the nearly all basic physiologic dynamics and they are key cells in the body's respiratory system by being responsible for the oxygen transport to
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all cells and tissues, and delivery of carbon dioxide to the lungs. With their flexible structure RBC are capable to deform in order to travel through all blood vessels including very small capillaries. Throughout their in average 120 days lifespan, human RBC travel in the bloodstream and come in contact with a broad range of different cell types. In fact, RBC are able to interact and communicate with endothelial cells (ECs), platelets, macrophages, and bacteria. Additionally, they are involved in the maintenance of thrombosis and hemostasis and play an important role in the immune response against pathogens. To clarify the mechanisms of interaction of RBC and these other cells both in health and disease as well as to highlight the role of important key players, we focused our interest on RBC membrane components such as ion channels, proteins, and phospholipids.
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Keywords: Endothelial cells, Interactions, Membrane proteins, Pathogens, Phospholipids, Plasma proteins, Platelets, Red blood cells, red blood cells, endothelial cells, plasma proteins, phospholipids, platelets, interactions, membrane proteins, pathogens, Physiology (medical), Physiology, Review, Journal Article
ISSN: 1664-042X
Publisher: Frontiers Research Foundation
Note: Funding Information: This work was supported by the European Union’s Horizon 2020 Research and Innovation Program under grant agreement No. 675115 – RELEVANCE – H2020-MSCA-ITN-2015/H2020-MSCA-ITN-2015. Funding Information: This work was supported by the European Union's Horizon 2020 Research and Innovation Program under grant agreement No. 675115 - RELEVANCE - H2020-MSCA-ITN-2015/H2020-MSCA-ITN-2015. Publisher Copyright: Copyright © 2019 Pretini, Koenen, Kaestner, Fens, Schiffelers, Bartels and Van Wijk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
(Peer reviewed)