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Now showing items 22661-22680 of 40729

Heterozygous Variants in the Mechanosensitive Ion Channel TMEM63A Result in Transient Hypomyelination during Infancy

Yan, Huifang; Helman, Guy; Murthy, Swetha E; Ji, Haoran; Crawford, Joanna; Kubisiak, Thomas; Bent, Stephen J; Xiao, Jiangxi; Taft, Ryan J; Coombs, Adam; Wu, Ye; Pop, Ana; Li, Dongxiao; de Vries, Linda S; Jiang, Yuwu; Salomons, Gajja S; van der Knaap, Marjo S; Patapoutian, Ardem; Simons, Cas; Burmeister, Margit; Wang, Jingmin; Wolf, Nicole I (Cell Press, 2019-11-07)

Mechanically activated (MA) ion channels convert physical forces into electrical signals. Despite the importance of this function, the involvement of mechanosensitive ion channels in human disease is poorly understood. ...
Development and characterization of liposomal formulation of bortezomib

Deshantri, Anil K; Metselaar, Josbert M; Zagkou, Stavroula; Storm, Gert; Mandhane, Sanjay N; Fens, Marcel H A M; Schiffelers, Raymond M (Elsevier, 2019-12-01)

Bortezomib is a proteasome inhibitor used for the treatment of multiple myeloma. The poor pharmacokinetic profile and off-target adverse effects provide a strong incentive to develop drug delivery systems for bortezomib. ...
Evidence-based guidelines for the management of abnormally invasive placenta recommendations from the International Society for Abnormally Invasive Placenta

International Society for Abnormally Invasive Placenta (IS-AIP) (Mosby Inc., 2019-06)

The worldwide incidence of abnormally invasive placenta is rapidly rising, following the trend of increasing cesarean delivery. It is a heterogeneous condition and has a high maternal morbidity and mortality rate, presenting ...
Symmetrical Thalamic Lesions in the Newborn: A Case Series

Pols, T; de Vries, L S; Salamon, A Soltirovska; Nikkels, P G J; Lichtenbelt, K D; Mulder-de Tollenaer, S M; Wezel-Meijler, G van (Georg Thieme Verlag, 2019-06)

Although bilateral injury to the thalami is often seen in (near)term infants with hypoxic ischemic encephalopathy (HIE), symmetrical thalamic lesions (STL) is a different, very rare condition, seen both in full-term and ...
Stress urinary incontinence after vaginal prolapse repair: development and internal validation of a prediction model with and without the stress test

van der Ploeg, J Marinus; Steyerberg, Ewout W; Zwolsman, Sandra E; van der Vaart, C Huub; Roovers, Jan-Paul W R (John Wiley & Sons Inc., 2019-04)

Objective: To develop a prediction model for stress urinary incontinence (SUI) after vaginal prolapse repair (postoperative stress urinary incontinence [POSUI]) and assess the value of a preoperative stress test. Patients ...
New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

Praest, Patrique; Liaci, A Manuel; Förster, Friedrich; Wiertz, Emmanuel J H J (Elsevier Limited, 2019-09-01)

Several hundred million years of co-evolution of vertebrates and invading pathogens have shaped the adaptive immune system to fight back the unwanted invaders through highly sophisticated defense mechanisms. Herpesviruses ...
Cinderella effect

Koop, K (2019-10-18)
A flow cytometry-based approach to unravel viral interference with the MHC class I antigen processing and presentation pathway

Praest, Patrique; de Buhr, Hendrik; Wiertz, Emmanuel J.H.J. (Humana Press Inc., 2019-05-31)

MHC class I molecules are an important component of the cell-mediated immune defense, presenting peptides to surveilling CD8+ cytotoxic T cells. During viral infection, MHC class I molecules carry and display viral peptides ...
Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

Graul, Malgorzata; Kisielnicka, Edyta; Rychlowski, Michal; Verweij, Marieke C.; Tobler, Kurt; Ackermann, Mathias; Wiertz, Emmanuel J.H.J.; Bieńkowska-Szewczyk, Krystyna; Lipińska, Andrea D. (Microbiology Society, 2019-03-01)

Bovine herpesvirus 1 (BoHV-1)-encoded UL49.5 (a homologue of herpesvirus glycoprotein N) can combine different functions, regulated by complex formation with viral glycoprotein M (gM). We aimed to identify the mechanisms ...
Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Wąchalska, Magda; Graul, Małgorzata; Praest, Patrique; Luteijn, Rutger D; Babnis, Aleksandra W; Wiertz, Emmanuel J H J; Bieńkowska-Szewczyk, Krystyna; Lipińska, Andrea D (Multidisciplinary Digital Publishing Institute (MDPI), 2019-12-07)

Transporter associated with antigen processing (TAP), a key player in the major histocompatibility complex class I-restricted antigen presentation, makes an attractive target for viruses that aim to escape the immune system. ...
Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability

Tang, Jiajia; Frascaroli, Giada; Lebbink, Robert J; Ostermann, Eleonore; Brune, Wolfram (National Academy of Sciences, 2019-09-03)

Human cytomegalovirus (HCMV), like many other DNA viruses, can cause genome instability and activate a DNA damage response (DDR). Activation of ataxia-telangiectasia mutated (ATM), a kinase activated by DNA breaks, is a ...
Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization

de Matos, Maria B. C.; Deckers, Roe; van Elburg, Benjamin; Lajoinie, Guillaume; de Miranda, Barbara S.; Versluis, Michel; Schiffelers, Raymond; Kok, Robbert J. (Frontiers Media S. A., 2019-12-05)

Mistletoe lectin-1 (ML1) is a nature-derived macromolecular cytotoxin that potently induces apoptosis in target cells. Non-specific cytotoxicity to normal cells is one of the major risks in its clinical application, and ...
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

Russell, Ashley E.; Sneider, Alexandra; Witwer, Kenneth W.; Bergese, Paolo; Bhattacharyya, Suvendra N.; Cocks, Alexander; Cocucci, Emanuele; Erdbrügger, Uta; Falcon-Perez, Juan M.; Freeman, David W.; Gallagher, Thomas M.; Hu, Shuaishuai; Huang, Yiyao; Jay, Steven M.; Kano, Shin ichi; Lavieu, Gregory; Leszczynska, Aleksandra; Llorente, Alicia M.; Lu, Quan; Mahairaki, Vasiliki; Muth, Dillon C.; Hooten, Nicole Noren; Ostrowski, Matias; Prada, Ilaria; Sahoo, Susmita; Schøyen, Tine Hiorth; Sheng, Lifu; Tesch, Deanna; Van Niel, Guillaume; Vandenbroucke, Roosmarijn E.; Verweij, Frederik J.; Villar, Ana V.; Wauben, Marca; Wehman, Ann M.; Yin, Hang; Carter, David Raul Francisco; Vader, Pieter (John Wiley & Sons Inc., 2019-12-01)

Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer ...
Reply to: Responsibility of scientific community in claiming to have found an association with recurrent pregnancy loss

Meuleman, Tess; Baden, N; Haasnoot, G W; Wagner, M M; Picavet, C; Dekkers, O M; Le Cessie, S; van Lith, J M M; Claas, F H J; Bloemenkamp, K W M (Elsevier Ireland Ltd, 2019-09-01)
Sawtooth Potassium and Hemoglobin Results

Musson, Ruben E.A.; Huisman, Albert; Nonkes, Lourens J.P.; Kemperman, Hans (Oxford University Press, 2019-10)
PlaqOmics Leducq Fondation Trans-Atlantic Network: Defining the Roles of Smooth Muscle Cells and Other Extracellular Matrix-Producing Cells in Late-Stage Atherosclerotic Plaque Pathogenesis

Owens, Gary K.; Pasterkamp, Gerard (Lippincott Williams & Wilkins, 2019-04-26)

Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic plaques represent the leading cause of death worldwide. However, the mechanisms that regulate plaque stability are poorly understood. Human ...
Design and characterization of alpha 1-antitrypsin variants for treatment of contact system-driven thromboinflammation

De Maat, Steven; Sanrattana, Wariya; Mailer, Reiner K.; Parr, Naomi M.J.; Hessing, Martin; Koetsier, Robert M.; Meijers, Joost C.M.; Pasterkamp, Gerard; Renné, Thomas; Maas, Coen (Elsevier, 2019-11-07)

The contact system produces the inflammatory peptide bradykinin and contributes to experimental thrombosis. C1 esterase-inhibitor (C1INH) deficiency or gain-of-function mutations in factor XII (FXII) cause hereditary ...
Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humans

van Keulen, Danielle; Pouwer, Marianne G.; Emilsson, Valur; Matic, Ljubica Perisic; Pieterman, Elsbet J.; Hedin, Ulf; Gudnason, Vilmundur; Jennings, Lori L.; Holmstrøm, Kim; Nielsen, Boye Schnack; Pasterkamp, Gerard; Lindeman, Jan H.N.; van Gool, Alain J.; Sollewijn Gelpke, Maarten D.; Princen, Hans M.G.; Tempel, Dennie (Public Library of Science, 2019-08-28)

Objective Previous studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with ...
Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model

Nederhoff, M. G.J.; Fransen, D. E.; Verlinde, S. A.M.W.; Brans, M. A.D.; Pasterkamp, G.; Bleys, R. L.A.W. (Elsevier, 2019-11-01)

Objectives: In cardiac ischemia, acute inflammatory responses further increase the detrimental effect on myocardial tissue. Since vagus nerve stimulation (VS) attenuates inflammatory responsiveness this study examines the ...
Preoperative hypertension is associated with atherosclerotic intraplaque hemorrhage in patients undergoing carotid endarterectomy

Fassaert, Leonie M.M.; Timmerman, Nathalie; van Koeverden, Ian D.; Pasterkamp, Gerard; de Kleijn, Dominique P.V.; de Borst, Gert J. (Elsevier, 2019-11-01)

BACKGROUND AND AIMS: Both hypertension and atherosclerotic plaque characteristics such as intraplaque hemorrhage (IPH) are associated with cardiovascular events (CVE). It is unknown if hypertension is associated with IPH. ...

Now showing items 22661-22680 of 40729