Effect of vagus nerve stimulation on tissue damage and function loss in a mouse myocardial ischemia-reperfusion model
Nederhoff, M. G.J.; Fransen, D. E.; Verlinde, S. A.M.W.; Brans, M. A.D.; Pasterkamp, G.; Bleys, R. L.A.W.
(2019) Autonomic Neuroscience: Basic and Clinical, volume 221
(Article)
Abstract
Objectives: In cardiac ischemia, acute inflammatory responses further increase the detrimental effect on myocardial tissue. Since vagus nerve stimulation (VS) attenuates inflammatory responsiveness this study examines the effect of VS on myocardial damage development in a cardiac ischemia-reperfusion (IR) mouse model. Methods: 54 male C57Bl/6j mice were subjected to an
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IR procedure with or without prior VS. The effects on inflammatory responsiveness, infarct size, cardiac function, neutrophils, lymphocytes and vascular endothelial growth factor (VEGF) in the infarcted myocardium were measured at 48 h after intervention. Group results were compared with unpaired Mann-Whitney or Kruskall-Wallis test. Results: A significant decrease in inflammatory responsiveness was not verified by decreased TNFα levels in blood from VS and IR treated mice. The percentage infarct size over area at risk was smaller in the group with VS + IR compared with IR (22.4 ± 10.2% vs 37.6 ± 9.0%, p = 0.003). The degree of the reduction in cardiac function was not different between the IR groups with or without VS and no group differences were found in amounts of neutrophils, CD3+ lymphocytes and VEGF in the reperfused mouse heart. Conclusion: The present study does not provide clear evidence of a reducing role for VS on cardiac function loss. This could mean that VS has a less inhibiting effect on myocardial inflammation than may be expected from the literature.
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Keywords: Heart, Inflammation, Ischemia, Reperfusion, Vagus nerve stimulation, Lymphocyte Subsets/immunology, Mice, Inbred C57BL, Male, Vagus Nerve Stimulation, Myocardium/chemistry, Stroke Volume, Neutrophils/immunology, Animals, Myocardial Reperfusion Injury/immunology, Tumor Necrosis Factor-alpha/blood, Models, Animal, Mice, Vascular Endothelial Growth Factor A/analysis, Endocrine and Autonomic Systems, Clinical Neurology, Cellular and Molecular Neuroscience, Research Support, Non-U.S. Gov't, Journal Article
ISSN: 1566-0702
Publisher: Elsevier
Note: Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
(Peer reviewed)