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Magnetic Resonance Imaging Identified Brain Ischaemia in Symptomatic Patients Undergoing Carotid Endarterectomy Is Related to Histologically Apparent Intraplaque Haemorrhage

Rots, Marjolijn L.; Timmerman, Nathalie; de Kleijn, Dominique P.V.; Pasterkamp, Gerard; Brown, Martin M.; Bonati, Leo H.; de Borst, Gert J. (W.B. Saunders Ltd, 2019-12-01)

Objective: Intraplaque haemorrhage (IPH) has been independently associated with a higher risk of future ipsilateral stroke in patients with carotid artery stenosis. Evaluation of plaque characteristics may contribute to ...
A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia

Gremmels, Hendrik; Teraa, Martin; de Jager, Saskia C.A.; Pasterkamp, Gerard; de Borst, Gert J.; Verhaar, Marianne C. (Nature Publishing Group, 2019-12-01)

Patients with Severe Limb Ischemia (SLI) have a high risk of amputation and mortality. Here, we investigated a panel of serum biomarkers with the aim of identifying biomarkers for major events and mechanisms that contribute ...
Afname van foetale en neonatale sterfte in Nederland: Vergelijking met andere Euro-Peristat-landen in 2004, 2010 en 2015

Broeders, Lisa; Achterberg, Peter W.; Waelput, Adja J.M.; Ravelli, Anita C.J.; Kwee, Anneke; Groenendaal, Floris; Offerhaus, Pien; van der Velden, Koos; Rosman, Ageeth N.; Nijhuis, Jan G. (Bohn Stafleu van Loghum, 2019-01-01)

OBJECTIVE: To compare changes in foetal, neonatal and perinatal mortality in the Netherlands in 2015, relative to 2004 and 2010, with changes in other European countries and regions. DESIGN: Descriptive population-wide ...
The CHOPIn Study: a Multicenter Study on Cerebellar Hemorrhage and Outcome in Preterm Infants

Boswinkel, V.; Steggerda, S. J.; Fumagalli, M.; Parodi, A.; Ramenghi, L. A.; Groenendaal, F.; Dudink, J.; Benders, M. N.; Knol, R.; de Vries, L. S.; van Wezel-Meijler, G. (Springer New York, 2019-12-01)

Cerebellar hemorrhage (CBH) is a frequent complication of preterm birth and may play an important and under-recognized role in neurodevelopment outcome. Association between CBH size, location, and neurodevelopment is still ...
The risk of intrapartum/neonatal mortality and morbidity following birth at 37 weeks of gestation: a nationwide cohort study

Eskes, M; Ensing, S; Groenendaal, F; Abu-Hanna, A; Ravelli, A C J (Wiley-Blackwell, 2019-09)

Objective: To assess intrapartum/neonatal mortality and morbidity risk in infants born at 37 weeks of gestation compared with infants born at 39–41 weeks of gestation. Design: Nationwide cohort study. Setting: The Netherlands. ...
Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients

Rab, Minke A.E.; van Oirschot, Brigitte A.; Bos, Jennifer; Merkx, Tesy H.; van Wesel, Annet C.W.; Abdulmalik, Osheiza; Safo, Martin K.; Versluijs, Birgitta A.; Houwing, Maite E.; Cnossen, Marjon H.; Riedl, Jurgen; Schutgens, Roger E.G.; Pasterkamp, Gerard; Bartels, Marije; van Beers, Eduard J.; van Wijk, Richard (John Wiley & Sons Inc., 2019-05-01)

In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation, resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced deformability, leading to vaso-occlusive crises ...
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS

Albrecht, Martin; Zitta, Karina; Groenendaal, Floris; van Bel, Frank; Peeters-Scholte, Cacha (Elsevier, 2019-10-01)

Perinatal asphyxia is characterized by oxygen deprivation and lack of perfusion in the perinatal period, leading to hypoxic-ischemic encephalopathy and sequelae such as cerebral palsy, mental retardation, cerebral visual ...
Dynamic prediction of bleeding risk in thrombocytopenic preterm neonates

Fustolo-Gunnink, Susanna F; Fijnvandraat, Karin; Putter, Hein; Ree, Isabelle M; Caram-Deelder, Camila; Andriessen, Peter; d'Haens, Esther J; Hulzebos, Christian V; Onland, Wes; Kroon, André A; Vijlbrief, Daniël C; Lopriore, Enrico; van der Bom, Johanna G (Ferrata Storti Foundation, 2019-10-30)

Over 75% of severely thrombocytopenic neonates receive platelet transfusions, though little evidence supports this practice, and only 10% develop major bleeding. In a recent randomized trial, giving platelet transfusions ...
Angiogenesis in Y-90-Radioembolization of Colorectal Liver Metastases

Alsultan, Ahmed A.; Barentsz, Maarten W.; Smits, Maarten L.J.; Koopman, Miriam; Lam, Marnix G.E.H.; Rosenbaum, Charlotte E.N.M. (W.B. Saunders, 2019-05)

In order to evaluate the role of angiogenesis in 90Y-radioembolization for colorectal cancer liver metastasis an overview was provided of angiogenic growth factors and their function, the angiogenic mechanisms in colorectal ...
Second autologous haematopoietic stem cell transplantation in systemic sclerosis-a case report

van Rhijn-Brouwer, Femke C C; Spierings, Julia; van Rhenen, Anna; Kuball, Jürgen; van Laar, Jacob M (Oxford University Press, 2019-07)
Influence of lanreotide on uptake of 68Ga-DOTATATE in patients with neuroendocrine tumours: a prospective intra-patient evaluation

Aalbersberg, E. A.; de Wit – van der Veen, B. J.; Versleijen, M. W.J.; Saveur, L. J.; Valk, G. D.; Tesselaar, M. E.T.; Stokkel, M. P.M. (Springer-Verlag, 2019-03-01)

Introduction: Somatostatin receptor imaging with PET is the standard of care for patients with a neuroendocrine tumour (NET). Since therapy and imaging with somatostatin analogues utilize the same receptor, current guidelines ...
Treatment thresholds for intervention in posthaemorrhagic ventricular dilation: a randomised controlled trial

de Vries, Linda S; Groenendaal, Floris; Liem, Kian D; Heep, Axel; Brouwer, Annemieke J; van 't Verlaat, Ellen; Benavente-Fernández, Isabel; van Straaten, Henrica Lm; van Wezel-Meijler, Gerda; Smit, Bert J; Govaert, Paul; Woerdeman, Peter A; Whitelaw, Andrew; ELVIS study group (BMJ Publishing Group, 2019-01)

Objective To compare a low versus a higher threshold for intervention in preterm infants with posthaemorrhagic ventricular dilatation. Design Multicentre randomised controlled trial (ISRCTN43171322). Setting 14 neonatal ...
Osteoarthritis: at the crossroads of metabolism and inflammation

Lippinkhof-Kozijn, Anne (Utrecht University, 2020-02-04)

This thesis aimed to investigate how metabolic overload contributes to the pathophysiology of knee OA. We explored the role of these independent yet intertwined processes using state-of-the-art lipidomic and cellular ...
Imaging of Head and Neck Cancer Patients Before, During and After Radiotherapy

Peltenburg, Boris (Utrecht University, 2020-02-04)

This thesis shows that before, during and after radiotherapy medical imaging can aid the treatment of HNSCC patients. This appears to be particularly true for MR imaging. It also shows that imaging has to be applied correctly ...
A longitudinal study of the evolution of the central sulcus’ shape in preterm infants using manifold learning

de Vareilles, Héloïse; Sun, Zhongyi; Benders, Manon; Fischer, Clara; Leroy, François; de Vries, Linda; Groenendaal, Floris; Rivière, Denis; Dubois, Jessica; Mangin, Jean François (Springer, 2019-01-01)

Cortical folding in humans is different for every individual, and is associated with functional specificities. It forms mainly during the last trimester of pregnancy, hence its development lacks description, especially in ...
Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project

EU-CERT-ICD Study Investigators (Churchill Livingstone, 2019-11)

Background: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients who benefit from prophylactic ICD therapy. ...
Clinical manifestations of neurosarcoidosis in the Netherlands

Voortman, Mareye; Fritz, Daan; Vogels, OJM; van de Beek, D; De Vries, J; Brouwer, MC; Drent, M. (2019)

Background Neurosarcoidosis is a rare disease. We investigated the prevalence of different manifestations of neurosarcoidosis and the influence of race or gender in the Netherlands, as well as the treatment strategies for ...
The Burden of Sarcoidosis Symptoms from a Patient Perspective

Voortman, M.; Hendriks, C. M.R.; Elfferich, M. D.P.; Bonella, F.; Møller, J.; De Vries, J.; Costabel, U.; Drent, M. (Springer New York, 2019-04-15)

Purpose: The clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence, sarcoidosis patients may suffer from a great variety of symptoms. The ...
Management of neurosarcoidosis: A clinical challenge

Voortman, Mareye; Drent, Marjolein; Baughman, Robert P. (Lippincott Williams & Wilkins, 2019-06-01)

Purpose of reviewSarcoidosis is a complex disease with many faces, and the clinical manifestation and course of neurosarcoidosis are particularly variable. Although neurosarcoidosis occurs in up to 10% of sarcoidosis ...
Everyday cognitive failure in patients suffering from neurosarcoidosis

Voortman, Mareye; De Vries, Jolanda; Hendriks, Celine M.R.; Elfferich, Marjon D.P.; Wijnen, Petal A.H.M.; Drent, Marjolein (Mattioli 1885 S.p.A., 2019-03-21)

Background: Cognitive failure is associated with memory and concentration problems. Previously, a prevalence of one third was found in a general sarcoidosis population. The aim of this study was to assess if neurosarcoidosis ...

Now showing items 22681-22700 of 40729