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Now showing items 20141-20160 of 40729

Lack of genotype-phenotype correlation in basal cell nevus syndrome: A Dutch multicenter retrospective cohort study

Cosgun, Betül; Reinders, Marie G.H.C.; van Geel, Michel; Steijlen, Peter M.; van Hout, Antonius F.W.; Leter, Edward M.; van der Smagt, Jasper J.; van Hagen, Johanna M.; Berger, Lieke P.V.; Kets, C. Marleen; Wagner, Anja; Aalfs, Cora M.; Hes, Frederik J.; van der Kolk, Lizet E.; Gille, Johan J.P.; Mosterd, Klara (Mosby Inc., 2020-08)
Young women's opinions on the use of a blood test to predict the possibility of premature ovarian failure: a qualitative study

Grootenhuis, Anouk; van den Hoogen, A; Broekmans, Frank J.M.; Torrance, Helen; van Os-Medendorp, Harmieke; Ockhuysen, HDL (Informa Healthcare, 2021-10)

The anti-Müllerian hormone (AMH) test is increasingly being used to predict the age when women will enter menopause, signalling the end of their reproductive life. However, the accuracy of the AMH test varies widely. In ...
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

Gupta, Ravindra K.; Abdul-Jawad, Sultan; McCoy, Laura E.; Mok, Hoi Ping; Peppa, Dimitra; Salgado, Maria; Martinez-Picado, Javier; Nijhuis, Monique; Wensing, Annemarie M.J.; Lee, Helen; Grant, Paul; Nastouli, Eleni; Lambert, Jonathan; Pace, Matthew; Salasc, Fanny; Monit, Christopher; Innes, Andrew J.; Muir, Luke; Waters, Laura; Frater, John; Lever, Andrew M.L.; Edwards, Simon G.; Gabriel, Ian H.; Olavarria, Eduardo (Nature Research, 2019-04-11)

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago 1,2 . The individual—who is known as the ‘Berlin patient’—underwent two allogeneic haematopoietic stem-cell transplantation (HSCT) ...
Response to: 'Novel NLRP12 variant presenting with familial cold autoimmunity syndrome phenotype' by Gupta et al

Eijkelboom, Charlotte; Ter Haar, Nienke M; Frenkel, Joost; Gattorno, Marco (Elsevier, 2021-07-01)
Complement factor H and apolipoprotein E participate in regulation of inflammation in THP-1 macrophages

Nissilä, Eija; Hakala, Pipsa; Leskinen, Katarzyna; Roig, Angela; Syed, Shahan; Van Kessel, Kok P.M.; Metso, Jari; De Haas, Carla J.C.; Saavalainen, Päivi; Meri, Seppo; Chroni, Angeliki; Van Strijp, Jos A.G.; Öörni, Katariina; Jauhiainen, Matti; Jokiranta, T. Sakari; Haapasalo, Karita (Frontiers Media S. A., 2018-11-21)

The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP ...
Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3)

Koymans, Kirsten J.; Feitsma, Louris J.; Bisschop, Adinda; Huizinga, Eric G.; Van Strijp, Jos A.G.; De Haas, Carla J.C.; McCarthy, Alex J. (BioMed Central Ltd., 2018-11-28)

Staphylococcus aureus is a versatile opportunistic pathogen, causing disease in human and animal species. Its pathogenicity is linked to the ability of S. aureus to secrete immunomodulatory molecules. These evasion proteins ...
Development curves of communication and social interaction in individuals with cerebral palsy

Perrin-Decade study group (Wiley-Blackwell, 2020-01-01)

AIM: To determine development curves of communication and social interaction from childhood into adulthood for individuals with cerebral palsy (CP). METHOD: This Pediatric Rehabilitation Research in the Netherlands ...
A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase

Buchan, Kyle D.; Prajsnar, Tomasz K.; Ogryzko, Nikolay V.; De Jong, Nienke W.M.; Van Gent, Michiel; Kolata, Julia; Foster, Simon J.; Van Strijp, Jos A.G.; Renshaw, Stephen A. (Public Library of Science, 2019-04-01)

The neutrophil enzyme myeloperoxidase (MPO) is a major enzyme made by neutrophils to generate antimicrobial and immunomodulatory compounds, notably hypochlorous acid (HOCl), amplifying their capacity for destroying pathogens ...
Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome

Van Den Hoogen, Lucas L.; Van Der Linden, Maarten; Meyaard, Linde; Fritsch-Stork, Ruth D.E.; Van Roon, Joel A.; Radstake, Timothy R.D.J. (Elsevier, 2020-10-01)
Higher risk of intracranial aneurysms and subarachnoid haemorrhage in siblings of families with intracranial aneurysms

Zuurbier, C. C.M.; Greving, J. P.; Rinkel, G. J.E.; Ruigrok, Y. M. (SAGE Publications Inc., 2020-03-01)

Introduction: First-degree relatives of patients with familial aneurysmal subarachnoid hemorrhage have an increased risk of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage. We assessed whether the ...
A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Janssen, Julie M; Dorlo, T P C; Niewerth, D; Wilhelm, A J; Zwaan, C M; Beijnen, J H; Attarbaschi, A; Baruchel, A; Fagioli, F; Klingebiel, T; De Moerloose, B; Palumbo, G; von Stackelberg, A; Kaspers, G J L; Huitema, A D R (Adis, 2020-02)

INTRODUCTION: The pharmacokinetics (PK) of the 20S proteasome inhibitor bortezomib are characterized by a large volume of distribution and a rapid decline in plasma concentrations within the first hour after administration. ...
Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

De Jong, Olivier G.; Kooijmans, Sander A.A.; Murphy, Daniel E.; Jiang, Linglei; Evers, Martijn J.W.; Sluijter, Joost P.G.; Vader, Pieter; Schiffelers, Raymond M. (American Chemical Society, 2019-07)

ConspectusExtracellular vesicles are nanoparticles produced by cells. They are composed of cellular membrane with associated membrane proteins that surrounds an aqueous core containing soluble molecules such as proteins ...
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy

Van Veluw, Susanne J.; Reijmer, Yael D.; Van Der Kouwe, Andre J.; Charidimou, Andreas; Riley, Grace A.; Leemans, Alexander; Bacskai, Brian J.; Frosch, Matthew P.; Viswanathan, Anand; Greenberg, Steven M. (Lippincott Williams & Wilkins, 2019-02-26)

ObjectiveWe sought to determine the underlying mechanism for altered white matter diffusion tensor imaging (DTI) measures at the histopathologic level in patients with cerebral amyloid angiopathy (CAA).MethodsFormalin-fixed ...
Multifocal motor neuropathy: controversies and priorities

Yeh, Wei Zhen; Dyck, P James; van den Berg, Leonard H; Kiernan, Matthew C; Taylor, Bruce V (BMJ Publishing Group, 2020-02-01)

Despite 30 years of research there are still significant unknowns and controversies associated with multifocal motor neuropathy (MMN) including disease pathophysiology, diagnostic criteria and treatment. Foremost relates ...
Measurement error in continuous endpoints in randomised trials: Problems and solutions

Nab, L.; Groenwold, R. H.H.; Welsing, P. M.J.; van Smeden, M. (John Wiley & Sons Inc., 2019-11-30)

In randomised trials, continuous endpoints are often measured with some degree of error. This study explores the impact of ignoring measurement error and proposes methods to improve statistical inference in the presence ...
Cognitive dysfunction in diabetes: how to implement emerging guidelines

Biessels, Geert J; Whitmer, Rachel A (Springer-Verlag, 2020-01)

Cognitive dysfunction, including mild cognitive impairment and dementia, is increasingly recognised as an important comorbidity and complication of diabetes that affects an individual's well-being and diabetes management, ...
Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer

van Kalmthout, L W M; van Melick, H H E; Lavalaye, J; Meijer, R P; Kooistra, A; de Klerk, J M H; Braat, A J A T; Kaldeway, H P; de Keizer, B; Lam, M G E H (Elsevier, 2020-03-01)

PURPOSE: Prospective validation of 68Ga prostate specific membrane antigen positron emission tomography/computerized tomography is lacking in initial staging of prostate cancer. In this study we evaluated the diagnostic ...
Underlying disease determines the risk of an open abdomen treatment, final closure, however, is determined by the surgical abdominal history

Karhof, Steffi; Haverkort, Mark; Simmermacher, Rogier; Hietbrink, Falco; Leenen, Luke; van Wessem, Karlijn (Springer International Publishing AG, 2021-02)

INTRODUCTION: Temporary abdominal closure is frequently used in several situations such as abbreviated surgery in damage control situations or when closing is impossible due to organ distention or increased abdominal ...
The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease

CF Clinics Study Group (Elsevier, 2020-07)

BACKGROUND: Recent standards of care mention chest radiography (CR) but not chest computed tomography (CT) in routine annual follow-up of children with cystic fibrosis (CF). To minimise radiation risk, CT or CR should only ...
The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity

Huang, Xiaobin; Zhong, Leilei; van Helvoort, Eefje; Lafeber, Floris; Mastbergen, Simon; Hendriks, Jan; Post, Janine N.; Karperien, Marcel (SAGE Publications Inc., 2021-10)

Objective: To investigate the presence of WNT antagonists Dickkopf-related protein 1 (DKK1), Frizzled-related protein (FRZB) and BMP antagonist Gremlin 1 (GREM1) in synovial fluid (SF) and serum, respectively, from end-stage ...

Now showing items 20141-20160 of 40729