Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness
Pries, L-K; Klingenberg, B; Menne-Lothmann, C; Decoster, J; van Winkel, R; Collip, D; Delespaul, P; De Hert, M; Derom, C; Thiery, E; Jacobs, N; Wichers, M; Cinar, O; Lin, B D; Luykx, J J; Rutten, B P F; van Os, J; Guloksuz, S
(2020) Acta Psychiatrica Scandinavica, volume 141, issue 5, pp. 465 - 475
(Article)
Abstract
OBJECTIVE: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures. METHODS: The data were retrieved from a general population twin cohort including 593 adolescents and young
... read more
adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models. RESULTS: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures. CONCLUSION: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.
show less
Download/Full Text
Keywords: childhood trauma, daily-life stressors, emotion regulation, experience sampling method, gene–environment interaction, psychosis, Psychiatry and Mental health, Journal Article
ISSN: 0001-690X
Publisher: Wiley-Blackwell
Note: Funding Information: The authors thank Jill Ielegems, Katrien Lyssens, Davinia Verhoeven, and Debora op’t Eijnde for data collection. The authors would like to acknowledge that the East Flanders Prospective Twin Survey (EFPTS) is partly supported by the Association for Scientific Research in Multiple Births and that the TwinssCan project is part of the European Community's Seventh Framework Program under grant agreement no. HEALTH‐F2‐2009‐241909 (Project EU‐GEI). Publisher Copyright: © 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd
(Peer reviewed)