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UMC Repository: Recent submissions

  • Degree and site of chromosomal instability define its oncogenic potential 
    Hoevenaar, Wilma H.M.; Janssen, Aniek; Quirindongo, Ajit I.; Ma, Huiying; Klaasen, Sjoerd J.; Teixeira, Antoinette; van Gerwen, Bastiaan; Lansu, Nico; Morsink, Folkert H.M.; Offerhaus, G. Johan A.; Medema, René H.; Kops, Geert J.P.L.; Jelluma, Nannette (Nature Publishing Group, 2020-03-20)
    Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal ...
  • Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder 
    Atagun, Murat Ilhan; Drukker, Marjan; Hall, Mei Hua; Altun, Ilkay Keles; Tatli, Safiye Zeynep; Guloksuz, Sinan; van Os, Jim; van Amelsvoort, Thérèse (Elsevier Ireland Ltd, 2020-06-30)
    The ability of the brain to reduce the amount of trivial or redundant sensory inputs is called gating function. Dysfunction of sensory gating may lead to cognitive fragmentation and poor real-world functioning. The auditory ...
  • SARS-CoV-2 productively infects human gut enterocytes 
    Lamers, Mart M; Beumer, Joep; van der Vaart, Jelte; Knoops, Kèvin; Puschhof, Jens; Breugem, Tim I; Ravelli, Raimond B G; Paul van Schayck, J; Mykytyn, Anna Z; Duimel, Hans Q; van Donselaar, Elly; Riesebosch, Samra; Kuijpers, Helma J H; Schippers, Debby; van de Wetering, Willine J; de Graaf, Miranda; Koopmans, Marion; Cuppen, Edwin; Peters, Peter J; Haagmans, Bart L; Clevers, Hans (American Association for the Advancement of Science, 2020-07-03)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory ...
  • Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine 
    Dijkstra, Krijn K; Monkhorst, Kim; Schipper, Luuk J; Hartemink, Koen J; Smit, Egbert F; Kaing, Sovann; de Groot, Rosa; Wolkers, Monika C; Clevers, Hans; Cuppen, Edwin; Voest, Emile E (Cell Press, 2020-05-05)
    Clinical implementation of tumor organoids for personalized medicine requires that pure tumor organoids can be reliably established. Here, we present our experience with organoid cultures from >70 non-small cell lung cancer ...
  • Automated cot-side tracking of functional brain age in preterm infants 
    Stevenson, Nathan J; Oberdorfer, Lisa; Tataranno, Maria-Luisa; Breakspear, Michael; Colditz, Paul B; de Vries, Linda S; Benders, Manon J N L; Klebermass-Schrehof, Katrin; Vanhatalo, Sampsa; Roberts, James A (John Wiley & Sons Inc., 2020-06-01)
    OBJECTIVE: A major challenge in the care of preterm infants is the early identification of compromised neurological development. While several measures are routinely used to track anatomical growth, there is a striking ...
  • Increase in Brain Volumes after Implementation of a Nutrition Regimen in Infants Born Extremely Preterm 
    van Beek, Pauline E; Claessens, Nathalie H P; Makropoulos, Antonios; Groenendaal, Floris; de Vries, Linda S; Counsell, Serena J; Benders, Manon J N L (Mosby Inc., 2020-08)
    Objective: To assess the effect of early life nutrition on structural brain development in 2 cohorts of extremely preterm infants, before and after the implementation of a nutrition regimen containing more protein and ...
  • Additional surgical procedures and perioperative morbidity in post-chemotherapy retroperitoneal lymph node dissection for metastatic testicular cancer in two intermediate volume hospitals 
    Blok, Joost M; Meijer, Richard P; van der Poel, Henk G; Bex, Axel; van Vooren, Jeanette; van Urk, Japke J; Horenblas, Simon; Bosch, J L H Ruud (Springer-Verlag, 2021-03)
    Purpose: To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. Methods: Retrospective analysis of 124 patients treated with open PC-RPLND at ...
  • Three Reasons Why Artificial Intelligence Might Be the Radiologist's Best Friend 
    van Rijn, Rick R; De Luca, Alberto (Radiological Society of North America Inc., 2020-07)
  • Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages 
    Rosenbluth, Jennifer M; Schackmann, Ron C J; Gray, G Kenneth; Selfors, Laura M; Li, Carman Man-Chung; Boedicker, Mackenzie; Kuiken, Hendrik J; Richardson, Andrea; Brock, Jane; Garber, Judy; Dillon, Deborah; Sachs, Norman; Clevers, Hans; Brugge, Joan S (Nature Publishing Group, 2020-04-06)
    Recently, organoid technology has been used to generate a large repository of breast cancer organoids. Here we present an extensive evaluation of the ability of organoid culture technology to preserve complex stem/progenitor ...
  • Electrophysiological abnormalities in VLCAD deficient hiPSC-cardiomyocytes can be improved by lowering accumulation of fatty acid oxidation intermediates 
    Knottnerus, Suzan J.G.; Mengarelli, Isabella; Wüst, Rob C.I.; Baartscheer, Antonius; Bleeker, Jeannette C.; Coronel, Ruben; Ferdinandusse, Sacha; Guan, Kaomei; Ijlst, Lodewijk; Li, Wener; Luo, Xiaojing; Portero, Vincent M.; Ulbricht, Ying; Visser, Gepke; Wanders, Ronald J.A.; Wijburg, Frits A.; Verkerk, Arie O.; Houtkooper, Riekelt H.; Bezzina, Connie R. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-08)
    Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological mechanism is unknown. We reprogrammed fibroblasts from one mildly and ...
  • The c.1A > C start codon mutation in CLN3 is associated with a protracted disease course 
    Kuper, Willemijn F E; van Alfen, Claudia; van Eck, Linda; de Man, Stella A; Willemsen, Marjolein H; van Gassen, Koen L I; Losekoot, Monique; van Hasselt, Peter M (Springer Berlin, 2020-03)
    Background: CLN3 disease is a disorder of lysosomal homeostasis predominantly affecting the retina and the brain. The severity of the underlying mutations in CLN3 particularly determines onset and course of neurological ...
  • Sex Differences in Symptom Presentation in Acute Coronary Syndromes: A Systematic Review and Meta-analysis 
    van Oosterhout, Roos E M; de Boer, Annemarijn R; Maas, Angela H E M; Rutten, Frans H; Bots, Michiel L; Peters, Sanne A E (Wiley-Blackwell, 2020-05-05)
    Background Timely recognition of patients with acute coronary syndromes (ACS) is important for successful treatment. Previous research has suggested that women with ACS present with different symptoms compared with men. ...
  • Health-related quality of life in patients with Multiple Endocrine Neoplasia type 1 
    van Leeuwaarde, Rachel S; Pieterman, Carolina R C; May, Anne M; Dekkers, Olaf M; van der Horst-Schrivers, Anouk N A; Hermus, Ad R; de Herder, Wouter; Drent, Madeleine L; Bisschop, Peter H; Havekes, Bas; Vriens, Menno R; Valk, Gerlof D (S. Karger AG, 2021-02)
    INTRODUCTION: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine tumor syndrome characterized by the triad of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumors (pNETs), and pituitary ...
  • Clinical implementation of MRI-based organs-at-risk auto-segmentation with convolutional networks for prostate radiotherapy. 
    Savenije, Mark; Maspero, Matteo; Sikkes, Gonda G; van der Voort van Zyp, Jochem; Kotte, ANTJ; Bol, GH; van den Berg, CAT (BioMed Central, 2020-05-11)
    BACKGROUND: Structure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promising ...
  • The additive value of restaging-CT during neoadjuvant chemotherapy for gastric cancer 
    Gertsen, E. C.; de Jongh, C.; Brenkman, H. J.F.; Mertens, A. C.; Broeders, I. A.M.J.; Los, M.; Boerma, D.; ten Bokkel Huinink, D.; van Leeuwen, L.; Wessels, F. J.; van Hillegersberg, R.; Ruurda, J. P. (W.B. Saunders Ltd, 2020-07)
    Introduction: Computed tomography (CT) is used for restaging of gastric cancer patients during neoadjuvant chemotherapy (NAC). The treatment strategy could be altered after detection of distant interval metastases, possibly ...
  • The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer 
    Streefkerk, Nina; Tissing, Wim J.E.; van der Heiden-van der Loo, Margriet; (Lieke) Feijen, Elizabeth A.M.; van Dulmen-den Broeder, Eline; Loonen, Jacqueline J.; van der Pal, Helena J.H.; Ronckers, Cécile M.; van Santen, Hanneke M.; van den Berg, Marleen H.; Mulder, Renée L.; Korevaar, Joke C.; Kremer, Leontine C.M. (Springer, 2020-10)
    Purposes: Studies investigating self-reported long-term morbidity in childhood cancer survivors (CCS) are using heterogeneous outcome definitions, which compromises comparability and include (un)treated asymptomatic and ...
  • Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome 
    van der Kroef, Maarten; van den Hoogen, Lucas L.; Mertens, Jorre S.; Blokland, Sofie L.M.; Haskett, Scott; Devaprasad, Abhinandan; Carvalheiro, Tiago; Chouri, Eleni; Vazirpanah, Nadia; Cossu, Marta; Wichers, Catherina G.K.; Silva-Cardoso, Sandra C.; Affandi, Alsya J.; Bekker, Cornelis P.J.; Lopes, Ana P.; Hillen, Maarten R.; Bonte-Mineur, Femke; Kok, Marc R.; Beretta, Lorenzo; Rossato, Marzia; Mingueneau, Michaël; van Roon, Joel A.G.; Radstake, Timothy R.D.J. (Wiley-VCH Verlag, 2020-01-01)
    Systemic sclerosis (SSc), systemic lupus erythematosus (SLE) and primary Sjögrens syndrome (pSS) are clinically distinct systemic autoimmune diseases (SADs) that share molecular pathways. We quantified the frequency of ...
  • CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis 
    van der Kroef, Maarten; Carvalheiro, Tiago; Rossato, Marzia; de Wit, Floor; Cossu, Marta; Chouri, Eleni; Wichers, Catharina G.K.; Bekker, Cornelis P.J.; Beretta, Lorenzo; Vazirpanah, Nadia; Trombetta, Elena; Radstake, Timothy R.D.J.; Angiolilli, Chiara (Academic Press Inc., 2020-07)
    Objective: To analyze how monocyte and macrophage exposure to CXCL4 induces inflammatory and fibrotic processes observed in Systemic sclerosis (SSc) patients. Methods: In six independent experiments, monocytes of healthy ...
  • Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications 
    Luchini, Claudio; Brosens, Lodewijk A A; Wood, Laura D; Chatterjee, Deyali; Shin, Jae Il; Sciammarella, Concetta; Fiadone, Giulia; Malleo, Giuseppe; Salvia, Roberto; Kryklyva, Valentyna; Piredda, Maria L; Cheng, Liang; Lawlor, Rita T; Adsay, Volkan; Scarpa, Aldo (BMJ Publishing Group, 2021-01)
    Objective: Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) have gained considerable interest due to the success of immunotherapy in this molecular setting. Here, we aim to clarify ...
  • Phenotypic spectrum of TGFB3 disease-causing variants in a Dutch-French cohort and first report of a homozygous patient 
    Marsili, Luisa; Overwater, Eline; Hanna, Nadine; Baujat, Geneviève; Baars, Marieke J H; Boileau, Catherine; Bonneau, Dominique; Brehin, Anne Claire; Capri, Yline; Cheung, Ho Y; Dulfer, Eelco; Gerard, Marion; Gouya, Laurent; Hilhorst-Hofstee, Yvonne; Houweling, Arjan C; Isidor, Bertrand; Le Gloan, Lauriane; Menke, Leonie A; Odent, Sylvie; Morice-Picard, Fanny; Vanlerberghe, Clemence; Voorhoeve, Els; van Tintelen, J Peter; Maugeri, Alessandra; Arnaud, Pauline (Wiley-Blackwell, 2020-05-01)
    Disease-causing variants in TGFB3 cause an autosomal dominant connective tissue disorder which is hard to phenotypically delineate because of the small number of identified cases. The purpose of this retrospective ...