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Now showing items 19421-19440 of 40729

The role of genetics in cardiovascular disease: arrhythmogenic cardiomyopathy

James, Cynthia A; Syrris, Petros; van Tintelen, J Peter; Calkins, Hugh (Oxford University Press, 2020-04-07)

Arrhythmogenic cardiomyopathy (ACM) is a heritable cardiomyopathy characterized by frequent ventricular arrhythmias and progressive ventricular dysfunction. Risk of sudden cardiac death is elevated in ACM patients and can ...
Orthotopic Bone Regeneration within 3D Printed Bioceramic Scaffolds with Region-Dependent Porosity Gradients in an Equine Model

Diloksumpan, Paweena; Bolaños, Rafael Vindas; Cokelaere, Stefan; Pouran, Behdad; de Grauw, Janny; van Rijen, Mattie; van Weeren, René; Levato, Riccardo; Malda, Jos (John Wiley & Sons Inc., 2020-05-01)

The clinical translation of three-dimensionally printed bioceramic scaffolds with tailored architectures holds great promise toward the regeneration of bone to heal critical-size defects. Herein, the long-term in vivo ...
One-Step Photoactivation of a Dual-Functionalized Bioink as Cell Carrier and Cartilage-Binding Glue for Chondral Regeneration

Lim, Khoon S; Abinzano, Florencia; Bernal, Paulina Nuñez; Albillos Sanchez, Ane; Atienza-Roca, Pau; Otto, Iris A; Peiffer, Quentin C; Matsusaki, Michiya; Woodfield, Tim B F; Malda, Jos; Levato, Riccardo (John Wiley & Sons Inc., 2020-08)

Cartilage defects can result in pain, disability, and osteoarthritis. Hydrogels providing a chondroregeneration-permissive environment are often mechanically weak and display poor lateral integration into the surrounding ...
Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue

Dubey, Nileshkumar; Ferreira, Jéssica; Malda, Jos; Bhaduri, Sarit B; Bottino, Marco C (American Chemical Society, 2020-05-27)

Bioprinting, a promising field in regenerative medicine, holds great potential to create three-dimensional, defect-specific vascularized bones with tremendous opportunities to address unmet craniomaxillofacial reconstructive ...
Bone Morphogenetic Protein-9 Is a Potent Chondrogenic and Morphogenic Factor for Articular Cartilage Chondroprogenitors

Morgan, Ben; Bauza-Mayol, Guillermo; Gardner, Oliver; Zhang, Yadan; Levato, Ricarrdo; Archer, Charles; van Weeren, Rene; Malda, Jos; Conlan, Robert Steven; Francis, Lewis; Khan, Ilyas (Mary Ann Liebert Inc., 2020-07-15)

Articular cartilage contains a subpopulation of tissue-specific progenitors that are an ideal cell type for cell therapies and generating neocartilage for tissue engineering applications. However, it is unclear whether the ...
Development of a clinical decision tool to reduce diagnostic testing for primary aldosteronism in patients with difficult-to-control hypertension

van Kleef, Monique E A M; Visseren, Frank L J; Westerink, Jan; Bots, Michiel L; Blankestijn, Peter J; van der Graaf, Yolanda; Spiering, Wilko (BioMed Central, 2020-04-29)

BACKGROUND: Satisfactory tools to preclude low-risk patients from intensive diagnostic testing for primary aldosteronism (PA) are lacking. Therefore, we aimed to develop a decision tool to determine which patients with ...
Renal denervation: time to refine the focus of research

Blankestijn, Peter J; Meijvis, Sabine C (Elsevier, 2020-05-02)
Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement

ARIA-MASK study group (Wiley-Blackwell, 2020-10)
Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement

ARIA-MASK study group (Wiley-Blackwell, 2020-07)

The current COVID-19 pandemic influences many areas of social life, medical treatments and the way allergy is performed. Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated ...
EAACI Research and Outreach Committee: Improving standards and facilitating global collaboration through a Research Excellence Network

Shamji, Mohamed H; Akdis, CezmiA; Barber, Domingo; Canonica, Walter; Chivato, Tomás; Del Giacco, Stefano; Hoffman-Sommergruber, Karin; Jutel, Marek; Knol, Edward; Ollert, Markus; O'Mahony, Liam; Palomares, Oscar; Sastre, Joaquin; Schwarze, Jürgen; SylwiaSmolinska; Vieths, Stephan; IoanaAgache (Wiley-Blackwell, 2020-08)

The European Academy of Allergy and Clinical Immunology (EAACI) is the leading organisation in the field of Allergy, Asthma and Clinical Immunology with nearly 12,000 members from 124 countries and works with over 70National ...
A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss

de Kok, Michèle J; Schaapherder, Alexander F; Mensink, Jacobus W; de Vries, Aiko P; Reinders, Marlies E; Konijn, Cynthia; Bemelman, Frederike J; van de Wetering, Jacqueline; van Zuilen, Arjan D; Christiaans, Maarten H; Baas, Marije C; Nurmohamed, Azam S; Berger, Stefan P; Ploeg, Rutger J; Alwayn, Ian P; Lindeman, Jan H (Elsevier, 2020-06)

Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available ...
Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

van der Wagen, Lotte E; Miranda-Bedate, Alberto; Janssen, Anke; Fernando, Febilla; Appukudige, Nagesha; van Dooremalen, Sanne F.J.; Westinga, Kasper; Admiraal, Rick; Lorenowicz, Magdalena J; Huls, Gerwin; Janssen, Jeroen J W M; Broers, Annoek E C; van der Velden, Walter J F M; van Marwijk Kooy, Rien; Hazenberg, Mette D; de Haar, Colin; Lindemans, Caroline; Jan Boelens, Jaap; Kuball, Jürgen (Springer Nature, 2020-11-01)
Comparison of reduced-intensity conditioning regimens in patients with acute lymphoblastic leukemia >45 years undergoing allogeneic stem cell transplantation-a retrospective study by the Acute Leukemia Working Party of EBMT

Peric, Zinaida; Labopin, Myriam; Peczynski, Christophe; Polge, Emmanuelle; Cornelissen, Jan; Carpenter, Ben; Potter, Mike; Malladi, Ram; Byrne, Jenny; Schouten, Harry; Fegueux, Nathalie; Socié, Gerard; Rovira, Montserrat; Kuball, Jurgen; Gilleece, Maria; Giebel, Sebastian; Nagler, Arnon; Mohty, Mohamad (Springer Nature, 2020-08-01)

The optimal reduced-intensity conditioning (RIC) for patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. We retrospectively analyzed ...
Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study

Cavo, Michele; Gay, Francesca; Beksac, Meral; Pantani, Lucia; Petrucci, Maria Teresa; Dimopoulos, Meletios A; Dozza, Luca; van der Holt, Bronno; Zweegman, Sonja; Oliva, Stefania; van der Velden, Vincent H J; Zamagni, Elena; Palumbo, Giuseppe A; Patriarca, Francesca; Montefusco, Vittorio; Galli, Monica; Maisnar, Vladimir; Gamberi, Barbara; Hansson, Markus; Belotti, Angelo; Pour, Ludek; Ypma, Paula; Grasso, Mariella; Croockewit, Alexsandra; Ballanti, Stelvio; Offidani, Massimo; Vincelli, Iolanda D; Zambello, Renato; Liberati, Anna Marina; Andersen, Niels Frost; Broijl, Annemiek; Troia, Rossella; Pascarella, Anna; Benevolo, Giulia; Levin, Mark-David; Bos, Gerard; Ludwig, Heinz; Aquino, Sara; Morelli, Anna Maria; Wu, Ka Lung; Boersma, Rinske; Hajek, Roman; Durian, Marc; von dem Borne, Peter A; Caravita di Toritto, Tommaso; Driessen, Christoph; Specchia, Giorgina; Waage, Anders; Gimsing, Peter; Mellqvist, Ulf-Henrik; van Marwijk Kooy, Marinus; Minnema, Monique; Mandigers, Caroline; Cafro, Anna Maria; Palmas, Angelo; Carvalho, Susanna; Spencer, Andrew; Boccadoro, Mario; Sonneveld, Pieter (Lancet Publishing Group, 2020-06)

BACKGROUND: The emergence of highly active novel agents has led some to question the role of autologous haematopoietic stem-cell transplantation (HSCT) and subsequent consolidation therapy in newly diagnosed multiple ...
Septum resection in women with a septate uterus: a cohort study

Rikken, J F W; Verhorstert, K W J; Emanuel, M H; Bongers, M Y; Spinder, T; Kuchenbecker, W; Jansen, F W; van der Steeg, J W; Janssen, C A H; Kapiteijn, K; Schols, W A; Torrenga, B; Torrance, H L; Verhoeve, H R; Huirne, J A F; Hoek, A; Nieboer, T E; van Rooij, I A J; Clark, T J; Robinson, L; Stephenson, M D; Mol, B W J; van der Veen, F; van Wely, M; Goddijn, M (Oxford University Press, 2020-07-01)

STUDY QUESTION: Does septum resection improve reproductive outcomes in women with a septate uterus? SUMMARY ANSWER: In women with a septate uterus, septum resection does not increase live birth rate nor does it decrease ...
Health-Related Quality of Life in Home Dialysis Patients Compared to In-Center Hemodialysis Patients: A Systematic Review and Meta-analysis

Bonenkamp, Anna A.; van Eck van der Sluijs, Anita; Hoekstra, Tiny; Verhaar, Marianne C.; van Ittersum, Frans J.; Abrahams, Alferso C.; van Jaarsveld, Brigit C. (Elsevier, 2020-03-01)

Rationale & Objective: Dialysis patients judge health-related quality of life (HRQoL) as an essential outcome. Remarkably, little is known about HRQoL differences between home dialysis and in-center hemodialysis (HD) ...
MRI cT1–2 rectal cancer staging accuracy: a population-based study

Dutch ColoRectal Audit Group* (John Wiley & Sons Inc., 2020-09)

Background: Adequate MRI-based staging of early rectal cancers is essential for decision-making in an era of organ-conserving treatment approaches. The aim of this population-based study was to determine the accuracy of ...
Rapid whole exome sequencing in pregnancies to identify the underlying genetic cause in fetuses with congenital anomalies detected by ultrasound imaging

Deden, Chantal; Neveling, Kornelia; Zafeiropopoulou, Dimitra; Gilissen, Christian; Pfundt, Rolph; Rinne, Tuula; de Leeuw, Nicole; Faas, Brigitte; Gardeitchik, Thatjana; Sallevelt, Suzanne C E H; Paulussen, Aimee; Stevens, Servi J C; Sikkel, Esther; Elting, Mariet W; van Maarle, Merel C; Diderich, Karin E M; Corsten-Janssen, Nicole; Lichtenbelt, Klaske D; Lachmeijer, Guus; Vissers, Lisenka E L M; Yntema, Helger G; Nelen, Marcel; Feenstra, Ilse; van Zelst-Stams, Wendy A G (John Wiley & Sons Inc., 2020-07)

Objective: The purpose of this study was to explore the diagnostic yield and clinical utility of trio-based rapid whole exome sequencing (rWES) in pregnancies of fetuses with a wide range of congenital anomalies detected ...
De novo variants in CUL3 are associated with global developmental delays with or without infantile spasms

Nakashima, Mitsuko; Kato, Mitsuhiro; Matsukura, Masaru; Kira, Ryutaro; Ngu, Lock-Hock; Lichtenbelt, Klaske D; van Gassen, Koen L I; Mitsuhashi, Satomi; Saitsu, Hirotomo; Matsumoto, Naomichi (Springer Nature, 2020-09)

The ubiquitin-proteasome system is the principal system for protein degradation mediated by ubiquitination and is involved in various cellular processes. Cullin-RING ligases (CRL) are one class of E3 ubiquitin ligases that ...
Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial

Gimbel, Marieke; Qaderdan, Khalid; Willemsen, Laura; Hermanides, Rik; Bergmeijer, Thomas; de Vrey, Evelyn; Heestermans, Ton; Tjon Joe Gin, Melvyn; Waalewijn, Reinier; Hofma, Sjoerd; den Hartog, Frank; Jukema, Wouter; von Birgelen, Clemens; Voskuil, Michiel; Kelder, Johannes; Deneer, Vera; Ten Berg, Jurriën (Elsevier, 2020-04-25)

BACKGROUND: Current guidelines recommend potent platelet inhibition with ticagrelor or prasugrel in patients after an acute coronary syndrome. However, data about optimal platelet inhibition in older patients are scarce. ...

Now showing items 19421-19440 of 40729