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Now showing items 17641-17660 of 40729

Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

van der Schoor, Laura; van Hattum, Emma J; de Wilde, Sophie M; Harlianto, Netanja I; van Weert, Aart-Jan; Bloothooft, Meye; van der Heyden, Marcel A G (Multidisciplinary Digital Publishing Institute (MDPI), 2020-08-11)

Inward rectifier potassium ion channels (IK1-channels) of the Kir2.x family are responsible for maintaining a stable negative resting membrane potential in excitable cells, but also play a role in processes of non-excitable ...
Efficacy of multi-electrode linear irreversible electroporation

Buist, Thomas J; Groen, Marijn H A; Wittkampf, Fred H M; Loh, Peter; Doevendans, PAFM; van Es, René; Elvan, Arif (Oxford University Press, 2021-03-08)

AIMS: We investigated the efficacy of linear multi-electrode irreversible electroporation (IRE) ablation in a porcine model. METHODS AND RESULTS: The study was performed in six pigs (weight 60-75 kg). After median sternotomy ...
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice

Rivaud, Mathilde R; Marchal, Gerard A; Wolswinkel, Rianne; Jansen, John A; van der Made, Ingeborg; Beekman, Leander; Ruiz-Villalba, Adrián; Baartscheer, Antonius; Rajamani, Sridharan; Belardinelli, Luiz; van Veen, Toon A B; Basso, Cristina; Thiene, Gaetano; Creemers, Esther E; Bezzina, Connie R; Remme, Carol Ann (Oxford University Press, 2020-10-01)

AIMS: SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) ...
Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy

van der Voorn, Stephanie M; Te Riele, Anneline S J M; Basso, Cristina; Calkins, Hugh; Remme, Carol Ann; van Veen, Toon A B (Oxford University Press, 2020-07-15)

Arrhythmogenic cardiomyopathy (ACM) is a life-threatening cardiac disease caused by mutations in genes predominantly encoding for desmosomal proteins that lead to alterations in the molecular composition of the intercalated ...
Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling

Vigil-Garcia, Marta; Demkes, Charlotte J; Eding, Joep E C; Versteeg, Danielle; de Ruiter, Hesther; Perini, Ilaria; Kooijman, Lieneke; Gladka, Monika M; Asselbergs, Folkert W; Vink, Aryan; Harakalova, Magdalena; Bossu, Alexander; van Veen, Toon A B; Boogerd, Cornelis J; van Rooij, Eva (Oxford University Press, 2021-06-01)

AIMS: Pathological cardiac remodelling is characterized by cardiomyocyte (CM) hypertrophy and fibroblast activation, which can ultimately lead to maladaptive hypertrophy and heart failure (HF). Genome-wide expression ...
Automated electrocardiographic quantification of myocardial scar in patients undergoing primary prevention implantable cardioverter-defibrillator implantation: Association with mortality and subsequent appropriate and inappropriate therapies

EU-CERT-ICD investigators (Elsevier, 2020-10)

Background: Myocardial scarring from infarction or nonischemic fibrosis forms an arrhythmogenic substrate. The Selvester QRS score has been developed to estimate myocardial scar from the 12-lead electrocardiogram. Objective: ...
In vivo analysis of the origin and characteristics of gaseous microemboli during catheter-mediated irreversible electroporation

Groen, Marijn H A; van Es, René; van Klarenbosch, Bas R; Stehouwer, Marco; Loh, Peter; Doevendans, Pieter; Wittkampf, Fred H; Neven, Kars (Oxford University Press, 2021-01-01)

Aims: Irreversible electroporation (IRE) ablation is a non-thermal ablation method based on the application of direct current between a multi-electrode catheter and skin electrode. The delivery of current through blood ...
A combined CaMKII inhibition and mineralocorticoid receptor antagonism via eplerenone inhibits functional deterioration in chronic pressure overloaded mice

Driessen, Helen E; Fontes, Magda S; van Stuijvenberg, Leonie; Brans, Maike A; Goumans, Marie-Jose; Vos, Marc A; van Veen, Toon A (Wiley-Blackwell, 2020-08)

In the diseased and remodelled heart, increased activity and expression of Ca2+/ calmodulin-dependent protein kinase II (CaMKII), an excess of fibrosis, and a decreased electrical coupling and cellular excitability leads ...
Electrocardiogram as a predictor of survival without appropriate shocks in primary prophylactic ICD patients: A retrospective multi-center study

Pelli, Ari; Kenttä, Tuomas V; Junttila, M Juhani; Bergau, Leonard; Zabel, Markus; Malik, Marek; Reichlin, Tobias; Willems, Rik; Vos, Marc A; Harden, Markus; Friede, Tim; Sticherling, Christian; Huikuri, Heikki V (Elsevier Ireland Ltd, 2020-06-15)

Background: Abnormal 12-lead electrocardiogram (ECG) can predict cardiovascular events, including sudden cardiac death. We tested the hypothesis that ECG provides useful information on guiding implantable cardioverter ...
Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study

Zabel, Markus; Willems, Rik; Lubinski, Andrzej; Bauer, Axel; Brugada, Josep; Conen, David; Flevari, Panagiota; Hasenfuß, Gerd; Svetlosak, Martin; Huikuri, Heikki V; Malik, Marek; Pavlović, Nikola; Schmidt, Georg; Sritharan, Rajevaa; Schlögl, Simon; Szavits-Nossan, Janko; Traykov, Vassil; Tuinenburg, Anton E; Willich, Stefan N; Harden, Markus; Friede, Tim; Svendsen, Jesper Hastrup; Sticherling, Christian; Merkely, Béla; EU-CERT-ICD Study Investigators (Oxford University Press, 2020-09-21)

Aims The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was ...
Pain Response After Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Patients With Bone Metastases-A Phase 2 Randomized Controlled Trial Within a Prospective Cohort

Pielkenrood, Bart J; van der Velden, Joanne M; van der Linden, Yvette M; M T Bartels, Marcia; Kasperts, Nicolien; Verhoeff, Joost J C; Eppinga, Wietse S C; Gal, Roxanne; Verlaan, Jorrit J; Verkooijen, H M Lenny (Elsevier, 2021-06-01)

PURPOSE: Pain response after conventional external beam radiation therapy (cRT) in patients with painful bone metastases is observed in 60% to 70% of patients. The aim of the VERTICAL trial was to investigate whether ...
The Current Status and Future Potential of Theranostics to Diagnose and Treat Childhood Cancer

Poot, Alex J; Lam, Marnix G E H; van Noesel, Max M (Frontiers Media S. A., 2020-11-19)

In theranostics (i.e., therapy and diagnostics) radiopharmaceuticals are used for both therapeutic and diagnostic purposes by targeting one specific tumor receptor. Biologically relevant compounds, e.g., receptor ligands ...
Improved repeatability of dynamic contrastenhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (vol 81, pg 3358, 2019): Improved repeatability of dynamic contrast-enhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (Magn Reson Med., (2019), 81, (3358–3369), 10.1002/mrm.27646)

Klawer, Edzo M E; van Houdt, Petra J; Simonis, Frank F J; van den Berg, Cornelis A T; Pos, Floris J; Heijmink, Stijn W T P J; Isebaert, Sofie; Haustermans, Karin; van der Heide, Uulke A (John Wiley & Sons Inc., 2021-04)

The antilog for the within-subject coefficient of variation (wCV) of log-transformed data was performed incorrectly. This leads to an increase by a factor of about 2 in the numbers in abstract, results section, Figure 4, ...
Real-time assessment of potential peak local specific absorption rate value without phase monitoring: Trigonometric maximization method for worst-case local specific absorption rate determination

Meliadò, Ettore Flavio; Sbrizzi, Alessandro; van den Berg, Cornelis A T; Luijten, Peter R; Raaijmakers, Alexander J E (John Wiley & Sons Inc., 2021-06)

PURPOSE: Multi-transmit MRI systems are typically equipped with dedicated hardware to sample the reflected/lost power in the transmit channels. After extensive calibration, the amplitude and phase of the signal at the feed ...
Endoscopic Resection Without Subsequent Ablation Therapy for Early Barrett’s Neoplasia: Endoscopic Findings and Long-Term Mortality

van Munster, S. N.; Nieuwenhuis, E. A.; Weusten, B. L.A.M.; Herrero, L. Alvarez; Bogte, A.; Alkhalaf, A.; Schenk, B. E.; Schoon, E. J.; Curvers, W.; Koch, A. D.; van de Ven, S. E.M.; de Jonge, P. J.F.; Tang, T.; Nagengast, W. B.; Peters, F. T.M.; Westerhof, J.; Houben, M. H.M.G.; Bergman, Jacques J.G.H.M.; Pouw, R. E.; on behalf of the Dutch Barrett Expert Centers (Springer New York, 2021-01)

Introduction: After endoscopic resection (ER) of neoplasia in Barrett’s esophagus (BE), it is recommended to ablate the remaining BE to minimize the risk for metachronous disease. However, we report long-term outcomes for ...
Venetoclax and Ibrutinib for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Niemann, Carsten Utoft; Levin, Mark-David; Dubois, Julie; Kersting, Sabina; Enggaard, Lisbeth; Veldhuis, Gerrit J; Mous, Rogier; Mellink, Clemens H. M.; Dobber, Johan A; Poulsen, Christian B.; Frederiksen, Henrik; Janssens, Ann; Schjødt, Ida; Dompeling, Ellen C; Ranti, Juha; Mattsson, Mattias; Bellido, Mar; Tran, Hoa T T; Nasserinejad, Kazem; Kater, Arnon P. (Elsevier, 2021-02-25)
Roux-en-Y gastric bypass in the elderly: is age a determining factor in our outcomes?

Turchi, Matías J; Kingma, Feike; Laborda, Nicolás; Montanelli, Agostina; Maldonado, Juan M; Fiolo, Felipe E (Elsevier, 2020-10)

BACKGROUND: While patients are becoming older and the prevalence of obesity increases worldwide, literature on the impact of age on outcomes after laparoscopic Roux-en-Y gastric bypass (LRYGB) is scarce. The balance between ...
Machine learning to predict early recurrence after oesophageal cancer surgery

OCCAMS Consortium (John Wiley & Sons Inc., 2020-07-01)

BACKGROUND: Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20-30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing ...
Comparing Circulating Tumor Cell Counts with Dynamic Tumor Size Changes as Predictor of Overall Survival: A Quantitative Modeling Framework

Netterberg, Ida; Karlsson, Mats O; Terstappen, Leon W M M; Koopman, Miriam; Punt, Cornelis J A; Friberg, Lena E (American Association for Cancer Research Inc., 2020-09-15)

PURPOSE: Quantitative relationships between treatment-induced changes in tumor size and circulating tumor cell (CTC) counts, and their links to overall survival (OS), are lacking. We present a population modeling framework ...
Practice variation on hospital level in the systemic treatment of metastatic colorectal cancer in The Netherlands: a population-based study

Keikes, Lotte; Koopman, Miriam; Stuiver, Martijn M; Lemmens, Valery E P P; van Oijen, Martijn G H; Punt, Cornelis J A (Informa Healthcare, 2020-04-02)

Introduction: Population-based data on the implementation of guidelines for cancer patients in daily practice are scarce, while practice variation may influence patient outcomes. Therefore, we evaluated treatment patterns ...

Now showing items 17641-17660 of 40729