Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium 
    Andrés-Delgado, Laura; Galardi-Castilla, María; Münch, Juliane; Peralta, Marina; Ernst, Alexander; González-Rosa, Juan Manuel; Tessadori, Federico; Santamaría, Luis; Bakkers, Jeroen; Vermot, Julien; de la Pompa, José Luis; Mercader, Nadia (Wiley-Liss Inc., 2020-12)
    BACKGROUND: The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It derives from the proepicardium (PE), cell clusters that appear ...
  • Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart 
    Man, Joyce Ck; van Duijvenboden, Karel; Krijger, Peter Hl; Hooijkaas, Ingeborg B; van der Made, Ingeborg; de Gier-de Vries, Corrie; Wakker, Vincent; Creemers, Esther E; de Laat, Wouter; Boukens, Bastiaan J; Christoffels, Vincent M (Lippincott Williams & Wilkins, 2021-01-08)
    RATIONALE: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic proteins in cardiac disease. The ...
  • Evolution of regulatory signatures in primate cortical neurons at cell-type resolution 
    Kozlenkov, Alexey; Vermunt, Marit W; Apontes, Pasha; Li, Junhao; Hao, Ke; Sherwood, Chet C; Hof, Patrick R; Ely, John J; Wegner, Michael; Mukamel, Eran A; Creyghton, Menno P; Koonin, Eugene V; Dracheva, Stella (National Academy of Sciences, 2020-11-10)
    The human cerebral cortex contains many cell types that likely underwent independent functional changes during evolution. However, cell-type-specific regulatory landscapes in the cortex remain largely unexplored. Here we ...
  • Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation 
    Hall, Amelia Weber; Chaffin, Mark; Roselli, Carolina; Lin, Honghuang; Lubitz, Steven A; Bianchi, Valerio; Geeven, Geert; Bedi, Kenneth; Margulies, Kenneth B; de Laat, Wouter; Tucker, Nathan R; Ellinor, Patrick T (Lippincott Williams & Wilkins, 2020-12)
    Background: Atrial fibrillation (AF) often arises from structural abnormalities in the left atria (LA). Annotation of the noncoding genome in human LA is limited, as are effects on gene expression and chromatin architecture. ...
  • CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids 
    Hendriks, Delilah; Clevers, Hans; Artegiani, Benedetta (Cell Press, 2020-11-05)
    CRISPR-Cas technology has revolutionized biological research and holds great therapeutic potential. Here, we review CRISPR-Cas systems and their latest developments with an emphasis on application to human cells. We also ...
  • The endothelium as Achilles' heel in COVID-19 patients 
    Gladka, Monika M; Maack, Christoph (Oxford University Press, 2020-12-01)
  • Translation and Replication Dynamics of Single RNA Viruses 
    Boersma, Sanne; Rabouw, Huib H; Bruurs, Lucas J M; Pavlovič, Tonja; van Vliet, Arno L W; Beumer, Joep; Clevers, Hans; van Kuppeveld, Frank J M; Tanenbaum, Marvin E (Elsevier, 2020-12-23)
    RNA viruses are among the most prevalent pathogens and are a major burden on society. Although RNA viruses have been studied extensively, little is known about the processes that occur during the first several hours of ...
  • Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture 
    Tjalsma, Sjoerd Jd; de Laat, Wouter (Elsevier Limited, 2021-04)
    Recent years have seen a vast expansion of knowledge on three-dimensional (3D) genome organization. The majority of studies on chromosome topology consists of pairwise interaction data of bulk populations of cells and ...
  • The Ig heavy chain protein but not its message controls early B cell development 
    Aslam, Muhammad Assad; Alemdehy, Mir Farshid; Hao, Bingtao; Krijger, Peter H L; Pritchard, Colin E J; de Rink, Iris; Muhaimin, Fitriari Izzatunnisa; Nurzijah, Ika; van Baalen, Martijn; Kerkhoven, Ron M; van den Berk, Paul C M; Skok, Jane A; Jacobs, Heinz (National Academy of Sciences, 2020-12-08)
    Development of progenitor B cells (ProB cells) into precursor B cells (PreB cells) is dictated by immunoglobulin heavy chain checkpoint (IgHCC), where the IgHC encoded by a productively rearranged Igh allele assembles into ...
  • Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease 
    Verstegen, Monique M A; Roos, Floris J M; Burka, Ksenia; Gehart, Helmuth; Jager, Myrthe; de Wolf, Maaike; Bijvelds, Marcel J C; de Jonge, Hugo R; Ardisasmita, Arif I; van Huizen, Nick A; Roest, Henk P; de Jonge, Jeroen; Koch, Michael; Pampaloni, Francesco; Fuchs, Sabine A; Schene, Imre F; Luider, Theo M; van der Doef, Hubert P J; Bodewes, Frank A J A; de Kleine, Ruben H J; Spee, Bart; Kremers, Gert-Jan; Clevers, Hans; IJzermans, Jan N M; Cuppen, Edwin; van der Laan, Luc J W (Nature Publishing Group, 2020-12-14)
    The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed ...
  • Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development 
    Adam, Ronja S; van Neerven, Sanne M; Pleguezuelos-Manzano, Cayetano; Simmini, Salvatore; Léveillé, Nicolas; de Groot, Nina E; Holding, Andrew N; Markowetz, Florian; Vermeulen, Louis (BioMed Central Ltd., 2020-12-03)
    BACKGROUND: Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early ...
  • Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex 
    Laban, Kamil G; Kalmann, Rachel; Leguit, Roos J; Uijttewaal, Peter H; Radstake, Timothy R D J; de Boer, Joke H; van der Veen, Rob L P (Wiley-Blackwell, 2021-08)
  • Long-term follow-up of neonatal intracranial haemorrhage in children with severe haemophilia 
    Andersson, Nadine G.; Wu, Runhui; Carcao, Manuel; Claeyssens-Donadel, Ségolène; Kobelt, Rainer; Liesner, Ri; Mäkipernaa, Anne; Ranta, Susanna; Ljung, Rolf; Auerswald, G.; Barnes, C.; Chalmers, E.; Chambost, H.; Clausen, N.; Dunn, A. L.; Escuriola Ettinghausen, C.; Fischer, K.; Fijnvandraat, K.; van Geet, C.; Hoffmann, M.; Kavakli, K.; Kenet, G.; Königs, C.; Kurnik, K.; Manco-Johnson, M.; Mancuso, M. E.; Molinari, C.; Muntean, W.; Nolan, B.; Perez Garrido, R.; Platokouki, E.; Rafowicz, A.; Santagostino, E.; Shapiro, A.; Thomas, A.; Williams, M. (Wiley-Blackwell, 2020-07-01)
  • The factor VIII treatment history of non-severe hemophilia A 
    Abdi, Amal; Kloosterman, Fabienne R.; Eckhardt, Corien L.; Male, Christoph; Castaman, Giancarlo; Fischer, Kathelijn; Beckers, Erik A.M.; Kruip, Marieke J.H.A.; Peerlinck, Kathelijne; Mancuso, Maria Elisa; Santoro, Cristina; Hay, Charles R.; Platokouki, Helen; van der Bom, Johanna G.; Gouw, Samantha C.; Fijnvandraat, Karin; Hart, Dan P.; INSIGHT Study Group (Wiley-Blackwell, 2020-12)
    Background: In patients with non-severe hemophilia A, we lack detailed knowledge on the timing of treatment with factor VIII (FVIII) concentrates. This knowledge could provide information about the expected treatment timing ...
  • Challenges and key lessons from the design and implementation of an international haemophilia registry supported by a pharmaceutical company 
    Hay, Charles R.M.; Shima, Midori; Makris, Michael; Jiménez-Yuste, Victor; Oldenburg, Johannes; Fischer, Kathelijn; Iorio, Alfonso; Skinner, Mark W.; Santagostino, Elena; von Mackensen, Sylvia; Kessler, Craig M. (Wiley-Blackwell, 2020-11)
    Introduction: Real-world data are lacking regarding the relationship between prospectively collected patient-reported outcomes (PROs), clinical outcomes and treatment in people with haemophilia (PWH). The Expanding ...
  • Novel F8 and F9 gene variants from the PedNet hemophilia registry classified according to ACMG/AMP guidelines 
    Andersson, Nadine G.; Labarque, Veerle; Letelier, Anna; Mancuso, Maria Elisa; Bührlen, Martina; Fischer, Kathelijn; Kartal-Kaess, Mutlu; Koskenvuo, Minna; Mikkelsen, Torben; Ljung, Rolf; PedNet Study Group (John Wiley & Sons Inc., 2020-12-01)
    In hemophilia A and B, analysis of the F8 and F9 gene variants enables carrier and prenatal diagnosis and prediction of risk for the development of inhibitors. The PedNet Registry collects clinical, genetic, and phenotypic ...
  • Robot-Assisted Minimally Invasive Esophagectomy with Intrathoracic Anastomosis (Ivor Lewis): Promising Results in 100 Consecutive Patients (the European Experience) 
    van der Sluis, Pieter Christiaan; Tagkalos, Evangelos; Hadzijusufovic, Edin; Babic, Benjamin; Uzun, Eren; van Hillegersberg, Richard; Lang, Hauke; Grimminger, Peter Philipp (Springer New York, 2021-01)
    Background: Robot-assisted minimally invasive esophagectomy (RAMIE) with intrathoracic anastomosis is gaining popularity as a treatment for esophageal cancer. The aim of this study was to describe postoperative complications ...
  • Standard anthracycline based versus docetaxel-capecitabine in early high clinical and/or genomic risk breast cancer in the EORTC 10041/BIG 3-04 MINDACT phase III trial 
    MINDACT investigators and the TRANSBIG Consortium (Lippincott Williams & Wilkins, 2020-04-10)
    PURPOSE MINDACT demonstrated that 46% of patients with early breast cancer at high clinical but low genomic risk on the basis of MammaPrint may safely avoid adjuvant chemotherapy. A second random assignment (R-C) compared ...
  • The influence of acute partial sleep deprivation on liking, choosing and consuming high- and low-energy foods 
    Benjamins, Jeroen S.; Hooge, Ignace T.C.; Benedict, Christian; Smeets, Paul A.M.; van der Laan, Laura N. (Elsevier Limited, 2021-03)
    A wealth of cross-sectional studies found a link between sleep deprivation and food-related outcomes like energy intake and BMI. Recent experimental studies suggest that this link is causal. However, the mechanisms through ...
  • Is zebrafish heart regeneration "complete"?: Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts 
    Bertozzi, Alberto; Wu, Chi-Chung; Nguyen, Phong D; Vasudevarao, Mohankrishna Dalvoy; Mulaw, Medhanie A; Koopman, Charlotte D; de Boer, Teun P; Bakkers, Jeroen; Weidinger, Gilbert (Academic Press Inc., 2021-03)
    Adult zebrafish are frequently described to be able to "completely" regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since existing evidence for cardiomyocyte proliferation ...