Improved repeatability of dynamic contrastenhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (vol 81, pg 3358, 2019): Improved repeatability of dynamic contrast-enhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (Magn Reson Med., (2019), 81, (3358–3369), 10.1002/mrm.27646)

Abstract

The antilog for the within-subject coefficient of variation (wCV) of log-transformed data was performed incorrectly. This leads to an increase by a factor of about 2 in the numbers in abstract, results section, Figure 4, Tables 2 and 3. Although this affected all wCV values reported in the manuscript, the conclusion remains the same. The authors regret this mistake and apologize for any inconvenience this may have caused. 4 FIGURE (Figure presented.) Bar plot of wCV values for Ktrans and kep for the three AIF methods including 95% CI bars 2 TABLE Median, range and wCV with 95% confidence interval of the AIF curve characteristics between the two consecutive exams (Table presented.) 3 TABLE The wCV between left and right AIFs, per method (magnitude, phase and complex signal), with 95% confidence interval for all curve characteristics (Table presented.) Abstract (changes in wCV values): Results: The wCV for peak height and full-width at half maximum for AIF COMPLEX (15% and 17%) indicated an improved repeatability compared to AIF MAGN (28% and 26%) and AIF PHASE (27% and 16%). This translated in lower wCV values for K trans (24%) with AIF COMPLEX in comparison to AIF MAGN (52%) and AIF PHASE (32%). For k ep the wCV was 35% with AIF MAGN, 29% with AIF PHASE, and 29% with AIF COMPLEX. Results section, “3.2 AIF curve characteristics per method”, P6 (changes in numbers): Without a B 1 correction, the peak height ratio for AIF MAGN increased to 1.5, whereas the wCV increased from 33 to 43%. Results section, “3. Tracer kinetic analysis”, P6 (changes in p-values): The wCV for K trans obtained with AIF MAGN was significantly larger than for the other two methods (p = 0.0026 and < 0.001 for AIF PHASE and AIF COMPLEX respectively), however, for k ep the wCV were not significantly larger (p = 0.59 and 0.63 for AIF PHASE and AIF COMPLEX respectively). Discussion, P9 (the word “higher” becomes “similar”): However, in general the reported wCV of K trans in ROIs is similar than what we observe for K trans obtained with AIF COMPLEX: range between 12.5% to 57%. 46-50.