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UMC Repository: Recent submissions

  • C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition 
    Lourenço, Ana Rita; Roukens, M. Guy; Seinstra, Danielle; Frederiks, Cynthia L.; Pals, Cornelieke E.; Vervoort, Stephin J.; Margarido, Andreia S.; van Rheenen, Jacco; Coffer, Paul J. (Nature Publishing Group, 2020-02-07)
    Extracellular signals such as TGF-β can induce epithelial-to-mesenchymal transition (EMT) in cancers of epithelial origin, promoting molecular and phenotypical changes resulting in pro-metastatic characteristics. We ...
  • Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland 
    Boardman, James P; Hall, Jill; Thrippleton, Michael J; Reynolds, Rebecca M; Bogaert, Debby; Davidson, Donald J; Schwarze, Jurgen; Drake, Amanda J; Chandran, Siddharthan; Bastin, Mark E; Fletcher-Watson, Sue (BMJ Publishing Group, 2020-03-04)
    INTRODUCTION: Preterm birth is closely associated with altered brain development and is a leading cause of neurodevelopmental, cognitive and behavioural impairments across the life course. We aimed to investigate neuroanatomic ...
  • 100 years of influenza research seen through the lens of Covid-19 
    Bogaert, Debby; Dockrell, David H (Elsevier, 2020-07-01)
  • Early Life Microbiota and Respiratory Tract Infections 
    de Steenhuijsen Piters, Wouter A A; Binkowska, Justyna; Bogaert, Debby (Cell Press, 2020-08-12)
    Over the last decade, it has become clear that respiratory and intestinal tract microbiota are related to pathogenesis of respiratory tract infections (RTIs). Host and environmental factors can drive respiratory microbiota ...
  • From doctors as patients: a manifesto for tackling persisting symptoms of covid-19 
    Alwan, Nisreen A; Attree, Emily; Blair, Jennifer Mary; Bogaert, Debby; Bowen, Mary-Ann; Boyle, John; Bradman, Madeleine; Briggs, Tracy Ann; Burns, Sarah; Campion, Daniel; Cushing, Katherine; Delaney, Brendan; Dixon, Chris; Dolman, Grace E; Dynan, Caitriona; Frayling, Ian M; Freeman-Romilly, Nell; Hammond, Iulia; Judge, Jenny; Järte, Linn; Lokugamage, Amali; MacDermott, Nathalie; MacKinnon, Mairi; Majithia, Visita; Northridge, Tanya; Powell, Laura; Rayner, Clare; Read, Ginevra; Sahu, Ekta; Shand, Claudia; Small, Amy; Strachan, Cara; Suett, Jake; Sykes, Becky; Taylor, Sharon; Thomas, Kevin; Thomson, Margarita; Wiltshire, Alexis; Woods, Victoria (BMJ Publishing Group, 2020-09-15)
  • Co-infections: potentially lethal and unexplored in COVID-19 
    Cox, Michael J; Loman, Nicholas; Bogaert, Debby; O'Grady, Justin (Elsevier, 2020-05)
  • Severity of Respiratory Infections With Seasonal Coronavirus Is Associated With Viral and Bacterial Coinfections 
    de Koff, Emma M; van Houten, Marlies A; Sanders, Elisabeth A M; Bogaert, Debby (Lippincott Williams & Wilkins, 2021-01)
    The clinical presentation of human coronavirus (HCoV) infections in children varies strongly. We show that children with an HCoV-associated lower respiratory tract infection more frequently had respiratory syncytial virus ...
  • Scientific consensus on the COVID-19 pandemic: we need to act now 
    Alwan, Nisreen A; Burgess, Rochelle Ann; Ashworth, Simon; Beale, Rupert; Bhadelia, Nahid; Bogaert, Debby; Dowd, Jennifer; Eckerle, Isabella; Goldman, Lynn R; Greenhalgh, Trisha; Gurdasani, Deepti; Hamdy, Adam; Hanage, William P; Hodcroft, Emma B; Hyde, Zoë; Kellam, Paul; Kelly-Irving, Michelle; Krammer, Florian; Lipsitch, Marc; McNally, Alan; McKee, Martin; Nouri, Ali; Pimenta, Dominic; Priesemann, Viola; Rutter, Harry; Silver, Joshua; Sridhar, Devi; Swanton, Charles; Walensky, Rochelle P; Yamey, Gavin; Ziauddeen, Hisham (Elsevier, 2020-10-31)
  • The UK needs a sustainable strategy for COVID-19 
    Gurdasani, Deepti; Bear, Laura; Bogaert, Debby; Burgess, Rochelle A; Busse, Reinhard; Cacciola, Roberto; Charpak, Yves; Colbourn, Tim; Drury, John; Friston, Karl; Gallo, Valentina; Goldman, Lynn R; Greenhalgh, Trisha; Hyde, Zoë; Kuppalli, Krutika; Majumder, Maimuna S; Martin-Moreno, Jose M; McKee, Martin; Michie, Susan; Mossialos, Elias; Nouri, Ali; Pagel, Christina; Pimenta, Dominic; Popescu, Saskia; Priesemann, Viola; Rasmussen, Angela L; Reicher, Stephen; Ricciardi, Walter; Rice, Ken; Silver, Joshua; Smith, Tara C; Wenham, Clare; West, Robert; Yamey, Gavin; Yates, Christian; Ziauddeen, Hisham (Elsevier, 2020-12-05)
  • The respiratory microbiota during and following mechanical ventilation for respiratory infections in children 
    de Koff, Emma M; Man, Wing Ho; van Houten, Marlies A; Jansen, Nicolaas J G; Arp, Kayleigh; Hasrat, Raiza; Sanders, Elisabeth A M; Bogaert, Debby (European Respiratory Society, 2021-04-01)
  • Costs of medication use among patients with juvenile idiopathic arthritis in the Dutch healthcare system 
    Kip, Michelle M A; de Roock, Sytze; Currie, Gillian; Marshall, Deborah A; Grazziotin, Luiza R; Twilt, Marinka; Yeung, Rae S M; Benseler, Susanne M; Schreijer, Maud A; Vastert, Sebastiaan J; Wulffraat, Nico; van Royen-Kerkhof, Annet; Swart, Joost F; IJzerman, Maarten J (Taylor and Francis Ltd., 2021-09-03)
    Background: This study aims to quantify medication costs in juvenile idiopathic arthritis (JIA), based on subtype. Research design and methods: This study is a single-center, retrospective analysis of prospective data from ...
  • A clinical prediction model for estimating the risk of developing uveitis in patients with juvenile idiopathic arthritis 
    Van Straalen, Joeri W.; Giancane, Gabriella; Amazrhar, Yasmine; Tzaribachev, Nikolay; Lazar, Calin; Uziel, Yosef; Telcharova-Mihaylovska, Albena; Len, Claudio A.; Miniaci, Angela; Boteanu, Alina L.; Filocamo, Giovanni; Mastri, Mariel V.; Arkachaisri, Thaschawee; Magnolia, Maria G.; Hoppenreijs, Esther; De Roock, Sytze; Wulffraat, Nico M.; Ruperto, Nicolino; Swart, Joost F. (Oxford University Press, 2021-06-18)
    Objective: To build a prediction model for uveitis in children with JIA for use in current clinical practice. Methods: Data from the international observational Pharmachild registry were used. Adjusted risk factors as well ...
  • Allergy Modulation by N-3 Long Chain Polyunsaturated Fatty Acids and Fat Soluble Nutrients of the Mediterranean Diet 
    Hogenkamp, Astrid; Ehlers, Anna; Garssen, Johan; Willemsen, Linette E M (Frontiers Media S. A., 2020-08-21)
    The Mediterranean diet, containing valuable nutrients such as n-3 long chain poly-unsaturated fatty acids (LCPUFAs) and other fat-soluble micronutrients, is known for its health promoting and anti-inflammatory effects. Its ...
  • ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants 
    ESP Dermatopathology Working Group (Springer-Verlag, 2021-07)
    The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation ...
  • Waiting list mortality and the potential of donation after circulatory death heart transplantations in the Netherlands 
    Roest, S; Kaffka Genaamd Dengler, S E; van Suylen, V; van der Kaaij, N P; Damman, K; van Laake, L W; Bekkers, J A; Dalinghaus, M; Erasmus, M E; Manintveld, O C (Bohn Stafleu van Loghum, 2021-02)
    BACKGROUND: With more patients qualifying for heart transplantation (HT) and fewer hearts being transplanted, it is vital to look for other options. To date, only organs from brain-dead donors have been used for HT in the ...
  • Immediate impact of COVID-19 on transplant activity in the Netherlands 
    de Vries, A P J; Alwayn, I P J; Hoek, R A S; van den Berg, A P; Ultee, F C W; Vogelaar, S M; Haase-Kromwijk, B J J M; Heemskerk, M B A; Hemke, A C; Nijboer, W N; Schaefer, B S; Kuiper, M A; de Jonge, J; van der Kaaij, N P; Reinders, M E J (Elsevier, 2020-08)
    The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged ...
  • Retrospective analysis of endocarditis patients to investigate the eligibility for oral antibiotic treatment in routine daily practice 
    Vroon, J C; Liesdek, O C D; Boel, C H E; Arends, J E; Niessen, F A; van Heusden, H C; Cramer, M J; van der Spoel, T I G; Chamuleau, S A J (Bohn Stafleu van Loghum, 2021-02)
    BACKGROUND: According to the current guidelines of the European Society of Cardiology, patients with left-sided infective endocarditis are treated with intravenous antibiotics for 4-6 weeks, leading to extensive hospital ...
  • In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves 
    Uiterwijk, Marcelle; Smits, Anthal I P M; van Geemen, Daphne; van Klarenbosch, Bas; Dekker, Sylvia; Cramer, Maarten Jan; van Rijswijk, Jan Willem; Lurier, Emily B; Di Luca, Andrea; Brugmans, Marieke C P; Mes, Tristan; Bosman, Anton W; Aikawa, Elena; Gründeman, Paul F; Bouten, Carlijn V C; Kluin, Jolanda (Elsevier, 2020-12)
    In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no ...
  • Surgically implanted aortic valve bioprostheses deform after implantation: insights from computed tomography 
    Faure, Marguerite E; Suchá, Dominika; Schwartz, Fides R; Symersky, Petr; Bogers, Ad J J C; Gaca, Jeffrey G; Koweek, Lynne M; de Heer, Linda M; Budde, Ricardo P J (Springer-Verlag, 2020-05-01)
    OBJECTIVE: Little is known about the prevalence and degree of deformation of surgically implanted aortic biological valve prostheses (bio-sAVRs). We assessed bio-sAVR deformation using multidetector-row computed tomography ...
  • Challenges and satisfaction in Cardiothoracic Surgery Residency Programmes: insights from a Europe-wide survey 
    Cerqueira, Rui J; Heuts, Samuel; Gollmann-Tepeköylü, Can; Syrjälä, Simo O; Keijzers, Marlies; Zientara, Alicja; Jarral, Omar A; Jacob, Kirolos A; Haunschild, Josephina; Ariyaratnam, Priyadharshanan; Durko, Andras P; Muller, Patrick; Myers, Patrick O; Sadaba, Justo Rafael; Lehtinen, Miia L (Oxford University Press, 2021-01-22)
    OBJECTIVES: The increasing complexity of surgical patients and working time constraints represent challenges for training. In this study, the European Association for Cardio-Thoracic Surgery Residents' Committee aimed to ...