In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
Uiterwijk, Marcelle; Smits, Anthal I P M; van Geemen, Daphne; van Klarenbosch, Bas; Dekker, Sylvia; Cramer, Maarten Jan; van Rijswijk, Jan Willem; Lurier, Emily B; Di Luca, Andrea; Brugmans, Marieke C P; Mes, Tristan; Bosman, Anton W; Aikawa, Elena; Gründeman, Paul F; Bouten, Carlijn V C; Kluin, Jolanda
(2020) JACC: Basic to Translational Science, volume 5, issue 12, pp. 1187 - 1206
(Article)
Abstract
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random
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or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
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Keywords: cell biology/structural biology, valvular heart disease, Cardiology and Cardiovascular Medicine
ISSN: 2452-302X
Publisher: Elsevier
Note: Funding Information: The authors would like to acknowledge Bente de Kort for performing the elastin assay, Marloes Janssen-van den Broek and Dr. Vivian Mouser for their expert help with the biaxial tensile tests, and Dr. Mark van Turnhout for his expert help in the quantifications of collagen and scaffold alignment. Funding Information: This research forms part of the iValve-II project, powered by Health∼Holland, top sector Life Sciences and Health (Grant number TTTI1403B), supported by the Dutch Ministry of Economic Affairs. This work was supported by the Netherlands Cardiovascular Research Initiative (CVON 2012-01): The Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development, the Royal Netherlands Academy of Sciences, and by the Gravitation Program “Materials Driven Regeneration,” funded by the Netherlands Organization for Scientific Research (024.003.013). Dr. Aikawa is supported by grants from the National Institutes of Health (R01 HL114805, R01 HL136431, R01 HL147095). Dr. Bouten is a shareholder of Xeltis BV. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Tristan and Mes are employees of Suprapolix BV. Dr. Brugmans is an employee of Xeltis BV. Publisher Copyright: © 2020 The Authors
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