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UMC Repository: Recent submissions

  • Cardiomyocyte ageing and cardioprotection: Consensus document from the ESC working groups cell biology of the heart and myocardial function 
    Ruiz-Meana, Marisol; Bou-Teen, Diana; Ferdinandy, Péter; Gyongyosi, Mariann; Pesce, Maurizio; Perrino, Cinzia; Schulz, Rainer; Sluijter, Joost P.G.; Tocchetti, Carlo G.; Thum, Thomas; Madonna, Rosalinda (Oxford University Press, 2020-09-01)
    Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases ...
  • The Dutch-Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases 
    Méndez Romero, Alejandra; Schillemans, Wilco; van Os, Rob; Koppe, Friederike; Haasbeek, Cornelis J; Hendriksen, Ellen M; Muller, Karin; Ceha, Heleen M; Braam, Pètra M; Reerink, Onne; Intven, Martijn P M; Joye, Ines; Jansen, Edwin P M; Westerveld, Henrike; Koedijk, Merel S; Heijmen, Ben J M; Buijsen, Jeroen (Elsevier, 2021-04-01)
    PURPOSE: Although various studies have reported that stereotactic body radiation therapy (SBRT) for liver metastases has high local control rates and relatively low toxicity, most series included a small number of patients. ...
  • The effects of fasting on drug metabolism 
    Lammers, Laureen A; Achterbergh, Roos; Mathôt, Ron A A; Romijn, Johannes A (Informa Healthcare, 2020-01-02)
    Introduction: There is considerable variability in the rates and extent of drug metabolism between patients due to physiological, genetic, pharmacologic, environmental and nutritional factors such as fasting. This variability ...
  • Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart 
    Bär, Christian; Chatterjee, Shambhabi; Falcão Pires, Inês; Rodrigues, Patrícia; Sluijter, Joost P G; Boon, Reinier A; Nevado, Rosa M; Andrés, Vicente; Sansonetti, Marida; de Windt, Leon; Ciccarelli, Michele; Hamdani, Nazha; Heymans, Stephane; Figuinha Videira, Raquel; Tocchetti, Carlo G; Giacca, Mauro; Zacchigna, Serena; Engelhardt, Stefan; Dimmeler, Stefanie; Madonna, Rosalinda; Thum, Thomas (Oxford University Press, 2020-09-01)
    Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that ...
  • Alignment of CanMEDS-based Undergraduate and Postgraduate Pharmacy Curricula in The Netherlands 
    Koster, Andries S; Mantel-Teeuwisse, Aukje K; Woerdenbag, Herman J; Mulder, Wilhelmina M C; Wilffert, Bob; Schalekamp, Tom; Buurma, Henk; Wilting, Ingeborg; Westein, Marnix P D (MDPI AG, 2020-07-10)
    In this article the design of three master programs (MSc in Pharmacy) and two postgraduate specialization programs for community or hospital pharmacist is described. After a preceding BSc in Pharmacy, these programs cover ...
  • Design strategies for promoting young children’s physical activity: A playscapes perspective 
    Boon, Boudewijn; Rozendaal, Marco C.; van den Heuvel-Eibrink, Marry M.; van der Net, Janjaap; van Grotel, Martine; Stappers, Pieter Jan (National Taiwan University of Science and Technology, 2020-12)
    This paper develops a set of design strategies for promoting young children’s physical activity. These strategies are developed by taking the design perspective of Playscapes as a starting point. Playscapes suggests that ...
  • Imaging Markers for the Characterization of Gray and White Matter Changes from Acute to Chronic Stages after Experimental Traumatic Brain Injury 
    Sinke, Michel R T; Otte, Willem M; Meerwaldt, Anu E; Franx, Bart A A; Ali, Mohamed H M; Rakib, Fazle; van der Toorn, Annette; van Heijningen, Caroline L; Smeele, Christel; Ahmed, Tariq; Blezer, Erwin L A; Dijkhuizen, Rick M (Mary Ann Liebert Inc., 2021-06-15)
    Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are ...
  • The tubarial glands paper: A starting point. A reply to comments 
    Valstar, Matthijs H; de Bakker, Bernadette S; Steenbakkers, Roel J H M; de Jong, Kees H; Smit, Laura A; Klein Nulent, Thomas J W; van Es, Robert J J; Hofland, Ingrid; de Keizer, Bart; Jasperse, Bas; Balm, Alfons J M; van der Schaaf, Arjen; Langendijk, Johannes A; Smeele, Ludi E; Vogel, Wouter V (Elsevier Ireland Ltd, 2021-01)
  • Impact of the COVID-19 Pandemic on Patient-Reported Outcomes of Breast Cancer Patients and Survivors 
    Bargon, Claudia A; Batenburg, Marilot C T; van Stam, Lilianne E; Mink van der Molen, Dieuwke R; van Dam, Iris E; van der Leij, Femke; Baas, Inge O; Ernst, Miranda F; Maarse, Wiesje; Vermulst, Nieke; Schoenmaeckers, Ernst J P; van Dalen, Thijs; Bijlsma, Rhodé M; Young-Afat, Danny A; Doeksen, Annemiek; Verkooijen, Helena M (Oxford University Press, 2021-02)
    Background: The coronavirus disease 2019 (COVID-19) pandemic (officially declared on the March 11, 2020), and the resulting measures, are impacting daily life and medical management of breast cancer patients and survivors. ...
  • Reference dosimetry in MRI-linacs: evaluation of available protocols and data to establish a code of practice 
    de Pooter, Jacco A; Billas, Ilias; de Prez, Leon Armand; Duane, Simon; Kapsch, Ralf-Peter; Karger, Christian; van Asselen, Bram; Wolthaus, Jochem W H (IOP Publishing Ltd., 2021-03-07)
    With the rapid increase in clinical treatments with MRI-linacs, a consistent, harmonized and sustainable ground for reference dosimetry in MRI-linacs is needed. Specific for reference dosimetry in MRI-linacs is the presence ...
  • Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization 
    Negussie, Ayele H; de Ruiter, Quirina M B; Britton, Hugh; Donahue, Danielle R; Boffi, Quentin; Kim, Young-Seung; Pritchard, William F; Moonen, Chrit; Storm, Gert; Lewis, Andrew L; Wood, Bradford J (Nature Publishing Group, 2021-12)
    Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic ...
  • Magnetic resonance imaging-based synthetic computed tomography of the lumbar spine for surgical planning: a clinical proof-of-concept 
    Staartjes, Victor E; Seevinck, Peter R; Vandertop, W Peter; van Stralen, Marijn; Schröder, Marc L (American Association of Neurological Surgeons, 2021-01)
    OBJECTIVE Computed tomography scanning of the lumbar spine incurs a radiation dose ranging from 3.5 mSv to 19.5 mSv as well as relevant costs and is commonly necessary for spinal neuronavigation. Mitigation of the need for ...
  • Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume 
    van der Kleij, Lisa A; De Vis, Jill B; de Bresser, Jeroen; Hendrikse, Jeroen; Siero, Jeroen C W (Springer Science and Business Media Deutschland GmbH, 2020-03-09)
    The Monro-Kellie hypothesis (MKH) states that volume changes in any intracranial component (blood, brain tissue, cerebrospinal fluid) should be counterbalanced by a co-occurring opposite change to maintain intracranial ...
  • A Rapid and Safe Infusion Protocol for Lu-177 Peptide Receptor Radionuclide Therapy 
    Ebbers, Sander C; Barentsz, Maarten W; de Keizer, Bart; Krijger, Gerard C; Lam, Marnix G E H; Braat, Arthur J A T (Society of Nuclear Medicine Inc., 2021-06-01)
    Peptide receptor radionuclide therapy (PRRT) with 177Lu-labeled somatostatin analogs in patients with somatostatin receptor-expressing tumors is often performed using administration protocols prescribing a 30-min infusion ...
  • Mechanisms of calcification in Fahr disease and exposure of potential therapeutic targets 
    Peters, Melissa E M; de Brouwer, Esther J M; Bartstra, Jonas W; Mali, Willem P Th M; Koek, Huiberdina L; Rozemuller, Annemieke J M; Baas, Annette F; de Jong, Pim A (Lippincott Williams & Wilkins, 2020-10)
    Purpose of review: There is growing interest in disorders involved in ectopic mineralization. Fahr disease or idiopathic basal ganglia calcification can serve as a model for ectopic mineralization in the basal ganglia, ...
  • Immunoglobulin Replacement Therapy Versus Antibiotic Prophylaxis as Treatment for Incomplete Primary Antibody Deficiency 
    Smits, Bas M; Kleine Budde, Ilona; de Vries, Esther; Ten Berge, Ineke J M; Bredius, Robbert G M; van Deuren, Marcel; van Dissel, Jaap T; Ellerbroek, Pauline M; van der Flier, Michiel; van Hagen, P Martin; Nieuwhof, Chris; Rutgers, Bram; Sanders, Lieke E A M; Simon, Anna; Kuijpers, Taco W; van Montfrans, Joris M (Springer New York, 2021-02)
    Background: Patients with an IgG subclass deficiency (IgSD) ± specific polysaccharide antibody deficiency (SPAD) often present with recurrent infections. Previous retrospective studies have shown that prophylactic antibiotics ...
  • Managing Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders: e-GLILDnet International Clinicians Survey 
    van de Ven, Annick A J M; Alfaro, Tiago M; Robinson, Alexandra; Baumann, Ulrich; Bergeron, Anne; Burns, Siobhan O; Condliffe, Alison M; Fevang, Børre; Gennery, Andrew R; Haerynck, Filomeen; Jacob, Joseph; Jolles, Stephen; Malphettes, Marion; Meignin, Véronique; Milota, Tomas; van Montfrans, Joris; Prasse, Antje; Quinti, Isabella; Renzoni, Elisabetta; Stolz, Daiana; Warnatz, Klaus; Hurst, John R (Frontiers Media S. A., 2020-11-26)
    Background: Granulomatous-lymphocytic interstitial lung disease (GLILD) is a rare, potentially severe pulmonary complication of common variable immunodeficiency disorders (CVID). Informative clinical trials and consensus ...
  • What Works When Treating Granulomatous Disease in Genetically Undefined CVID?: A Systematic Review 
    van Stigt, Astrid C; Dik, Willem A; Kamphuis, Lieke S J; Smits, Bas M; van Montfrans, Joris M; van Hagen, P Martin; Dalm, Virgil A S H; IJspeert, Hanna (Frontiers Media S. A., 2020-12-17)
    Background: Granulomatous disease is reported in at least 8-20% of patients with common variable immunodeficiency (CVID). Granulomatous disease mainly affects the lungs, and is associated with significantly higher morbidity ...
  • First-line treatment with infliximab versus conventional treatment in children with newly diagnosed moderate-to-severe Crohn's disease: an open-label multicentre randomised controlled trial 
    Jongsma, Maria M E; Aardoom, Martine A; Cozijnsen, Martinus A; van Pieterson, Merel; de Meij, Tim; Groeneweg, Michael; Norbruis, Obbe F; Wolters, Victorien M; van Wering, Herbert M; Hojsak, Iva; Kolho, Kaija-Leena; Hummel, Thalia; Stapelbroek, Janneke; van der Feen, Cathelijne; van Rheenen, Patrick F; van Wijk, Michiel P; Teklenburg-Roord, Sarah T A; Schreurs, Marco W J; Rizopoulos, Dimitris; Doukas, Michail; Escher, Johanna C; Samsom, Janneke N; de Ridder, Lissy (BMJ Publishing Group, 2020-12-31)
    In newly diagnosed paediatric patients with moderate-to-severe Crohn's disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed ...
  • Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis 
    Ludikhuize, Marlies C.; Meerlo, Maaike; Gallego, Marc Pages; Xanthakis, Despina; Burgaya Julià, Mar; Nguyen, Nguyen T.B.; Brombacher, Eline C.; Liv, Nalan; Maurice, Madelon M.; Paik, Ji hye; Burgering, Boudewijn M.T.; Rodriguez Colman, Maria J. (Cell Press, 2020-11-03)
    Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial activity supports CBCs, while adjacent Paneth ...