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UMC Repository: Recent submissions

  • Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy 
    Reschke, Cristina R.; Silva, Luiz F.A.; Vangoor, Vamshidhar R.; Rosso, Massimo; David, Bastian; Cavanagh, Brenton L.; Connolly, Niamh M.C.; Brennan, Gary P.; Sanz-Rodriguez, Amaya; Mooney, Catherine; Batool, Aasia; Greene, Chris; Brennan, Marian; Conroy, Ronan M.; Rüber, Theodor; Prehn, Jochen H.M.; Campbell, Matthew; Pasterkamp, R. Jeroen; Henshall, David C. (Cell Press, 2021-06-02)
    Oligonucleotide therapies offer precision treatments for a variety of neurological diseases, including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB). Previous studies showed that intracerebr ...
  • Physiological and Pathological Ageing of Astrocytes in the Human Brain 
    Verkerke, Marloes; Hol, Elly M.; Middeldorp, Jinte (Springer New York, 2021-10)
    Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease ...
  • National point prevalence study on carriage of multidrug-resistant microorganisms in Dutch long-term care facilities in 2018 
    PPO study group (Oxford University Press, 2021-06-01)
    Objectives: Long-Term care facilities (LTCFs) may act as a reservoir of ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) for hospitals and the general population. In this study, ...
  • Reactive astrocyte nomenclature, definitions, and future directions 
    Escartin, Carole; Galea, Elena; Lakatos, András; O’Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhäuser, Christian; Volterra, Andrea; Carmignoto, Giorgio; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Díaz-Castro, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Götz, Magdalena; Gutiérrez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Iino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; Lee, C. Justin; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Murai, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stéphane H.R.; Oliveira, João F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Pérez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina Beate; Wood, Levi B.; Wu, Jiaqian; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael V.; Verkhratsky, Alexei (Nature Research, 2021-03)
    Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ...
  • Model-based evaluation of school- and non-school-related measures to control the COVID-19 pandemic 
    Rozhnova, Ganna; van Dorp, Christiaan H; Bruijning-Verhagen, Patricia; Bootsma, Martin C J; van de Wijgert, Janneke H H M; Bonten, Marc J M; Kretzschmar, Mirjam E (Nature Publishing Group, 2021-03-12)
    The role of school-based contacts in the epidemiology of SARS-CoV-2 is incompletely understood. We use an age-structured transmission model fitted to age-specific seroprevalence and hospital admission data to assess the ...
  • One year improvement of exercise capacity in patients with mechanical circulatory support as bridge to transplantation 
    Felix, Susanne E A; Oerlemans, Martinus I F; Ramjankhan, Faiz Z; Muller, Steven A; Kirkels, Hans H; van Laake, Linda W; Suyker, Willem J L; Asselbergs, Folkert W; de Jonge, Nicolaas (John Wiley & Sons Inc., 2021-06)
    AIMS: Mechanical circulatory support (MCS) results in substantial improvement of prognosis and functional capacity. Currently, duration of MCS as a bridge to transplantation (BTT) is often prolonged due to shortage of donor ...
  • Severe thrombotic microangiopathy after autologous stem cell transplantation in systemic sclerosis: A case report 
    Sharif, Maryam O.; Leavis, Helen L.; van Paassen, Pieter; van Rhenen, Anna; Timmermans, Sjoerd A.M.E.G.; Ton, Evelien; Laar, Jacob M.van; Spierings, Julia (Oxford University Press, 2021-09-01)
  • Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution 
    Busslinger, Georg A; Weusten, Bas L A; Bogte, Auke; Begthel, Harry; Brosens, Lodewijk A A; Clevers, Hans (Cell Press, 2021-03-09)
    The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum, controls food transport, digestion, nutrient uptake, and hormone production. By single-cell analysis of healthy epithelia of these human ...
  • Scoring of tumour response after neoadjuvant therapy in resected pancreatic cancer: systematic review 
    van Roessel, S; Janssen, B V; Soer, E C; Fariña Sarasqueta, A; Verbeke, C S; Luchini, C; Brosens, L A A; Verheij, J; Besselink, M G (John Wiley & Sons Inc., 2021-02)
    BACKGROUND: Preoperative chemo(radio)therapy is used increasingly in pancreatic cancer. Histological evaluation of the tumour response provides information on the efficacy of preoperative treatment and is used to determine ...
  • HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy 
    Jacobs, Julia; Zijlmans, Maeike (American Epilepsy Society, 2020-10-22)
    The study of high frequency oscillations (HFO) in the electroencephalogram (EEG) as biomarkers of epileptic activity has merely focused on their spatial location and relationship to the epileptogenic zone. It has been ...
  • What is the best drug treatment for premenopausal women with bleeding irregularities using the levonorgestrel-releasing intrauterine system?: A systematic review 
    van der Heijden, P A H H; Tibosch, R M G; Geomini, P M A J; Veersema, S; Bullens, L M; Delvaux, E J L G; Bui, B N; Bongers, M Y (Informa Healthcare, 2020-11-01)
    OBJECTIVE: Up to 60% of women discontinue using the levonorgestrel-releasing intrauterine system (LNG-IUS) within 5 years because of bleeding irregularities, pain and/or systemic progestogenic adverse effects. The aim of ...
  • Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery? 
    van Klink, Nicole E C; Zweiphenning, Willemiek J E M; Ferrier, Cyrille H; Gosselaar, Peter H; Miller, Kai J; Aronica, Eleonora; Braun, Kees P J; Zijlmans, Maeike (Wiley-Blackwell, 2021-04)
    Objective: In people with low-grade intrinsic brain tumors, an epileptic focus is often located close to the lesion. High-frequency oscillations (HFOs) in electrocorticography (ECoG) might help to delineate this focus. We ...
  • Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding 
    Beelen, Pleun; van den Brink, Marian J; Herman, Malou C; Geomini, Peggy M A J; Dekker, Janny H; Duijnhoven, Ruben G; Mak, Nienke; van Meurs, Hannah S; Coppus, Sjors F; van der Steeg, Jan Willem; Eising, Heleen P; Massop-Helmink, Diana S; Klinkert, Ellen R; Nieboer, Theodoor E; Timmermans, Anne; van der Voet, Lucet F; Veersema, Sebastiaan; Smeets, Nicol A C; Schutte, Joke M; van Baal, Marchien; Bossuyt, Patrick M; Mol, Ben Willem J; Berger, Marjolein Y; Bongers, Marlies Y (Mosby Inc., 2021-02)
    BACKGROUND: Heavy menstrual bleeding affects the physical functioning and social well-being of many women. The levonorgestrel-releasing intrauterine system and endometrial ablation are 2 frequently applied treatments in ...
  • Challenges in Removing the Essure® Device 
    van Gastel, Daniëlle M; Maassen, Liselotte W; Koks, Carolien A M; Veersema, Sebastiaan; Bongers, Marlies Y (John Wiley & Sons Inc., 2020)
    We present a case about Essure® removal surgery in which the third markers of the device have torn off. The woman needed a second surgery for complete removal of the devices. Fluoroscopy during surgery is a good method to ...
  • A standard operating procedure for developing and hosting a webinar for healthcare professionals new to online teaching 
    Hennus, Marije P; van Dam, Marjel (Oxford University Press, 2021-11-01)
  • The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2) 
    Franken, Gijs A.C.; Müller, Dominik; Mignot, Cyril; Keren, Boris; Lévy, Jonathan; Tabet, Anne Claude; Germanaud, David; Tejada, María Isabel; Kroes, Hester Y.; Nievelstein, Rutger A.J.; Brimble, Elise; Ruzhnikov, Maria; Claverie-Martin, Felix; Szczepańska, Maria; Ćuk, Martin; Latta, Femke; Konrad, Martin; Martínez-Cruz, Luis A.; Bindels, René J.M.; Hoenderop, Joost G.J.; Schlingmann, Karl Peter; de Baaij, Jeroen H.F. (John Wiley & Sons Inc., 2021-04)
    Hypomagnesemia, seizures, and intellectual disability (HSMR) syndrome is a rare disorder caused by mutations in the cyclin M2 (CNNM2) gene. Due to the limited number of cases, extensive phenotype analyses of these patients ...
  • Provisional Stenting for the Treatment of Bifurcation Lesions: In Vitro Insights 
    Ng, C K Jaryl; Paradies, Valeria; Vlachojannis, George J; Toh, Han Wei; Leo, Hwa Liang; Wong, E H Philip; Foin, Nicolas; Ang, Hui Ying (Springer New York, 2021-08)
    Provisional stenting is considered the gold standard approach for most bifurcation lesions, but the benefit of routine side branch (SB) strut dilatation has not been fully elucidated. A benchtop model was used to determine ...
  • Ocular complications of oak processionary caterpillar setae in the Netherlands; case series, literature overview, national survey and treatment advice 
    Tan, Matthew K H; Jalink, Maarten B; Sint Jago, Naïlah F M; Ho, Lintje; Arnold van Vliet, J H; Das, Tridib; de Faber, Jan Tjeerd H N; Wisse, Robert P L (Wiley-Blackwell, 2021-06)
    During early summer 2019, the Netherlands experienced an outbreak of the exotic oak processionary caterpillar. The vast number of caterpillars, which live in large nests on oak trees before they turn into moths, possess ...
  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction 
    INVENT Consortium (Oxford University Press, 2021-03-01)
    Aims While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic ...
  • Quality of vision and vision-related quality of life after Descemet membrane endothelial keratoplasty: a randomized clinical trial 
    Dunker, Suryan L; Dickman, Mor M; Wisse, Robert P L; Nobacht, Siamak; Wijdh, Robert H J; Bartels, Marjolijn C; Tang, N E Mei-Lie; van den Biggelaar, Frank J H M; Kruit, Pieter J; Winkens, Bjorn; Nuijts, Rudy M M A (Wiley-Blackwell, 2021-11)
    Purpose: To compare quality of vision and vision-related quality of life (QOL) in patients undergoing Descemet membrane endothelial keratoplasty (DMEK) or ultrathin Descemet stripping automated endothelial keratoplasty ...