Physiological and Pathological Ageing of Astrocytes in the Human Brain

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Physiological and Pathological Ageing of Astrocytes in the Human Brain
 
Verkerke, Marloes; Hol, Elly M.; Middeldorp, Jinte
(2021) Neurochemical Research, volume 46, issue 10, pp. 2662 - 2675
(Article)
Abstract
Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer’s disease and is highly expressed in astrocytes. There are indications that human astrocytes change with age and ... read more
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Keywords: Ageing, Alzheimer’s disease, APOE, Human astrocyte, iPSC, Post-mortem human brain tissue, Reactive gliosis, Alzheimer&#8217, s disease, Cellular and Molecular Neuroscience, Biochemistry
DOI: https://doi.org/10.1007/s11064-021-03256-7
ISSN: 0364-3190
Publisher: Springer New York
Note: Funding Information: JM was supported by ZonMw (733050504) and EMH and JM by ZonMw (733050816)—The Netherlands Organisation for Health Research and Development, Dementia Research and Innovation Program “Memorabel” with additional support from Alzheimer Nederland. EMH and JM were supported by Alzheimer Nederland (WE.03-2017-04). ZonMw and Alzheimer Nederland projects are part of the cooperative “Deltaplan for Dementia”, the Dutch national platform to address and manage the growing problem of dementia. JM received support from the Brain Center UMC Utrecht, Rudolf Magnus Talent fellowship. MV is supported by the Dutch Research Council (NWO) Graduate Program (022.006.001). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
(Peer reviewed)